Alteration of humoral, cellular and cytokine immune response to inactivated influenza vaccine in patients with Sickle Cell Disease

• Published in: PloS one Vol. 14; no. 10; p. e0223991
• Main Authors: Nagant, Carole, Barbezange, Cyril, Dedeken, Laurence, Besse-Hammer, Tatiana, Thomas, Isabelle, Mahadeb, Bhavna, Efira, André, Ferster, Alice, Corazza, Francis
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 10.10.2019; Public Library of Science (PLoS)
• Subjects: Adult; Age; Aged; Anemia, Sickle Cell - complications; Anemia, Sickle Cell - immunology; Antigens; B cells; Biology and Life Sciences; Blood; Blood transfusion; Care and treatment; CAT scans; CD8 antigen; CD8-Positive T-Lymphocytes - immunology; Cell activation; Cell-mediated immunity; Clinical trials; Complications; Cytokines; Female; Flow cytometry; Genetic aspects; Health risks; Hematology; Humans; Humoral immunity; Hydroxyurea; Immune response; Immune response (humoral); Immune system; Immunogenicity; Immunologic Memory; Immunological memory; Immunology; Immunoregulation; Infections; Influenza; Influenza vaccines; Influenza Vaccines - adverse effects; Influenza Vaccines - immunology; Influenza Vaccines - therapeutic use; Influenza viruses; Influenza, Human - complications; Influenza, Human - immunology; Influenza, Human - therapy; Interferon-gamma - blood; Interleukin 10; Interleukin-10 - blood; Lymphocytes; Lymphocytes B; Lymphocytes T; Male; Medical law; Medical research; Medicine and Health Sciences; Memory cells; Middle Aged; Oncology; Pandemics; Patients; Seasons; Seroconversion; Sickle cell anemia; Sickle cell disease; Studies; Subgroups; T cells; Vaccination; Vaccination - adverse effects; Vaccines; Viruses; Belgium; United States > US; California

Patients suffering from Sickle Cell Disease (SCD) are at increased risk for complications due to influenza virus. Annual influenza vaccination is strongly recommended but few clinical studies have assessed its immunogenicity in individuals with SCD. The aim of this study was to explore the biologica...