Rheumatoid arthritis is associated with rs17337023 polymorphism and increased serum level of the EGFR protein

• Published in: PloS one Vol. 12; no. 7; p. e0180604
• Main Authors: Huang, Chung-Ming, Chen, Hsin-Han, Chen, Da-Chung, Huang, Yu-Chuen, Liu, Shih-Ping, Lin, Ying-Ju, Chang, Yuan-Yen, Lin, Hui-Wen, Chen, Shih-Yin, Tsai, Fuu-Jen
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 11.07.2017; Public Library of Science (PLoS)
• Subjects: Adult; Aged; Arthritis; Arthritis, Rheumatoid - blood; Arthritis, Rheumatoid - genetics; Biology and Life Sciences; Chi-Square Distribution; Clinical trials; Deoxyribonucleic acid; Development and progression; DNA; Enzyme-Linked Immunosorbent Assay; Epidermal growth factor; Epidermal growth factor receptors; Female; Fibroblasts; Gene expression; Gene Frequency - genetics; Gene polymorphism; Genetic aspects; Genetic Predisposition to Disease - genetics; Genetics; Genotype; Genotyping; Haplotypes; Haplotypes - genetics; Hospitals; Humans; Immunology; Inflammation; Ligands; Male; Medical research; Medicine; Medicine and Health Sciences; Middle Aged; Patients; People and Places; Polymerase chain reaction; Polymorphism; Polymorphism, Restriction Fragment Length - genetics; Polymorphism, Single Nucleotide - genetics; Population; Population studies; Proteins; Receptor, Epidermal Growth Factor - blood; Receptor, Epidermal Growth Factor - genetics; Research and Analysis Methods; Restriction fragment length polymorphism; Rheumatoid arthritis; Rheumatology; Rodents; Signal transduction; Single nucleotide polymorphisms; Single-nucleotide polymorphism; Statistical analysis; Statistical methods; Taiwan; China

We have previously described the association of rheumatoid arthritis (RA) prevalence and two epidermal growth factor receptor (EGFR) SNPs (rs17337023 and rs2227983) among the Taiwanese population. This present study aimed to elucidate whether the SNPs can alter the expression of EGFR in the progress...