Rheumatoid arthritis is associated with rs17337023 polymorphism and increased serum level of the EGFR protein
We have previously described the association of rheumatoid arthritis (RA) prevalence and two epidermal growth factor receptor (EGFR) SNPs (rs17337023 and rs2227983) among the Taiwanese population. This present study aimed to elucidate whether the SNPs can alter the expression of EGFR in the progress...
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| Published in | PloS one Vol. 12; no. 7; p. e0180604 |
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| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
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Public Library of Science
11.07.2017
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| Abstract | We have previously described the association of rheumatoid arthritis (RA) prevalence and two epidermal growth factor receptor (EGFR) SNPs (rs17337023 and rs2227983) among the Taiwanese population. This present study aimed to elucidate whether the SNPs can alter the expression of EGFR in the progression of RA.
The cohort study included 366 Taiwan's Han Chinese RA patients and 326 age and gender matched healthy controls. Blood samples collected from the participants were analyzed to determine their serum EGFR levels and to identify EGFR SNPs from their genomic DNA. Genotyping for EGFR SNPs was performed by restriction fragment length polymorphism (RFLP) assay. The relationship between EGFR SNP and the clinical manifestations of RA was evaluated.
Our results showed that a statistically significant difference in genotype frequency distributions at rs17337023 SNP for RA patients and controls (p ˂ 0.05). In addition, compared with the haplotype frequencies between case and control groups, the RA patient with the GT haplotype appeared to be a significant "protective" haplotype compared with other haplotypes (OR: 0.73, 95% CI: 0.59-0.91; p = 0.005). Furthermore, the increased serum level of EGFR was also observed in RA patients (p ˂ 0.001).
Our study showed that RA is associated with rs17337023 SNP in EGFR gene and increased serum level of the EGFR protein. These findings suggest EGFR is worthy of further investigation as a therapeutic target for RA. |
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| AbstractList | We have previously described the association of rheumatoid arthritis (RA) prevalence and two epidermal growth factor receptor (EGFR) SNPs (rs17337023 and rs2227983) among the Taiwanese population. This present study aimed to elucidate whether the SNPs can alter the expression of EGFR in the progression of RA.OBJECTIVEWe have previously described the association of rheumatoid arthritis (RA) prevalence and two epidermal growth factor receptor (EGFR) SNPs (rs17337023 and rs2227983) among the Taiwanese population. This present study aimed to elucidate whether the SNPs can alter the expression of EGFR in the progression of RA.The cohort study included 366 Taiwan's Han Chinese RA patients and 326 age and gender matched healthy controls. Blood samples collected from the participants were analyzed to determine their serum EGFR levels and to identify EGFR SNPs from their genomic DNA. Genotyping for EGFR SNPs was performed by restriction fragment length polymorphism (RFLP) assay. The relationship between EGFR SNP and the clinical manifestations of RA was evaluated.METHODSThe cohort study included 366 Taiwan's Han Chinese RA patients and 326 age and gender matched healthy controls. Blood samples collected from the participants were analyzed to determine their serum EGFR levels and to identify EGFR SNPs from their genomic DNA. Genotyping for EGFR SNPs was performed by restriction fragment length polymorphism (RFLP) assay. The relationship between EGFR SNP and the clinical manifestations of RA was evaluated.Our results showed that a statistically significant difference in genotype frequency distributions at rs17337023 SNP for RA patients and controls (p ˂ 0.05). In addition, compared with the haplotype frequencies between case and control groups, the RA patient with the GT haplotype appeared to be a significant "protective" haplotype compared with other haplotypes (OR: 0.73, 95% CI: 0.59-0.91; p = 0.005). Furthermore, the increased serum level of EGFR was also observed in RA patients (p ˂ 0.001).RESULTSOur results showed that a statistically significant difference in genotype frequency distributions at rs17337023 SNP for RA patients and controls (p ˂ 0.05). In addition, compared with the haplotype frequencies between case and control groups, the RA patient with the GT haplotype appeared to be a significant "protective" haplotype compared with other haplotypes (OR: 0.73, 95% CI: 0.59-0.91; p = 0.005). Furthermore, the increased serum level of EGFR was also observed in RA patients (p ˂ 0.001).Our study showed that RA is associated with rs17337023 SNP in EGFR gene and increased serum level of the EGFR protein. These findings suggest EGFR is worthy of further investigation as a therapeutic target for RA.CONCLUSIONOur study showed that RA is associated with rs17337023 SNP in EGFR gene and increased serum level of the EGFR protein. These findings suggest EGFR is worthy of further investigation as a therapeutic target for RA. We have previously described the association of rheumatoid arthritis (RA) prevalence and two epidermal growth factor receptor (EGFR) SNPs (rs17337023 and rs2227983) among the Taiwanese population. This present study aimed to elucidate whether the SNPs can alter the expression of EGFR in the progression of RA. The cohort study included 366 Taiwan's Han Chinese RA patients and 326 age and gender matched healthy controls. Blood samples collected from the participants were analyzed to determine their serum EGFR levels and to identify EGFR SNPs from their genomic DNA. Genotyping for EGFR SNPs was performed by restriction fragment length polymorphism (RFLP) assay. The relationship between EGFR SNP and the clinical manifestations of RA was evaluated. Our results showed that a statistically significant difference in genotype frequency distributions at rs17337023 SNP for RA patients and controls (p < 0.05). In addition, compared with the haplotype frequencies between case and control groups, the RA patient with the GT haplotype appeared to be a significant "protective" haplotype compared with other haplotypes (OR: 0.73, 95% CI: 0.59-0.91; p = 0.005). Furthermore, the increased serum level of EGFR was also observed in RA patients (p < 0.001). Our study showed that RA is associated with rs17337023 SNP in EGFR gene and increased serum level of the EGFR protein. These findings suggest EGFR is worthy of further investigation as a therapeutic target for RA. Objective We have previously described the association of rheumatoid arthritis (RA) prevalence and two epidermal growth factor receptor (EGFR) SNPs (rs17337023 and rs2227983) among the Taiwanese population. This present study aimed to elucidate whether the SNPs can alter the expression of EGFR in the progression of RA. Methods The cohort study included 366 Taiwan's Han Chinese RA patients and 326 age and gender matched healthy controls. Blood samples collected from the participants were analyzed to determine their serum EGFR levels and to identify EGFR SNPs from their genomic DNA. Genotyping for EGFR SNPs was performed by restriction fragment length polymorphism (RFLP) assay. The relationship between EGFR SNP and the clinical manifestations of RA was evaluated. Results Our results showed that a statistically significant difference in genotype frequency distributions at rs17337023 SNP for RA patients and controls (p < 0.05). In addition, compared with the haplotype frequencies between case and control groups, the RA patient with the GT haplotype appeared to be a significant "protective" haplotype compared with other haplotypes (OR: 0.73, 95% CI: 0.59-0.91; p = 0.005). Furthermore, the increased serum level of EGFR was also observed in RA patients (p < 0.001). Conclusion Our study showed that RA is associated with rs17337023 SNP in EGFR gene and increased serum level of the EGFR protein. These findings suggest EGFR is worthy of further investigation as a therapeutic target for RA. Objective We have previously described the association of rheumatoid arthritis (RA) prevalence and two epidermal growth factor receptor (EGFR) SNPs (rs17337023 and rs2227983) among the Taiwanese population. This present study aimed to elucidate whether the SNPs can alter the expression of EGFR in the progression of RA. Methods The cohort study included 366 Taiwan’s Han Chinese RA patients and 326 age and gender matched healthy controls. Blood samples collected from the participants were analyzed to determine their serum EGFR levels and to identify EGFR SNPs from their genomic DNA. Genotyping for EGFR SNPs was performed by restriction fragment length polymorphism (RFLP) assay. The relationship between EGFR SNP and the clinical manifestations of RA was evaluated. Results Our results showed that a statistically significant difference in genotype frequency distributions at rs17337023 SNP for RA patients and controls ( p ˂ 0.05). In addition, compared with the haplotype frequencies between case and control groups, the RA patient with the GT haplotype appeared to be a significant “protective” haplotype compared with other haplotypes (OR: 0.73, 95% CI: 0.59–0.91; p = 0.005). Furthermore, the increased serum level of EGFR was also observed in RA patients ( p ˂ 0.001). Conclusion Our study showed that RA is associated with rs17337023 SNP in EGFR gene and increased serum level of the EGFR protein. These findings suggest EGFR is worthy of further investigation as a therapeutic target for RA. We have previously described the association of rheumatoid arthritis (RA) prevalence and two epidermal growth factor receptor (EGFR) SNPs (rs17337023 and rs2227983) among the Taiwanese population. This present study aimed to elucidate whether the SNPs can alter the expression of EGFR in the progression of RA.The cohort study included 366 Taiwan's Han Chinese RA patients and 326 age and gender matched healthy controls. Blood samples collected from the participants were analyzed to determine their serum EGFR levels and to identify EGFR SNPs from their genomic DNA. Genotyping for EGFR SNPs was performed by restriction fragment length polymorphism (RFLP) assay. The relationship between EGFR SNP and the clinical manifestations of RA was evaluated.Our results showed that a statistically significant difference in genotype frequency distributions at rs17337023 SNP for RA patients and controls (p ˂ 0.05). In addition, compared with the haplotype frequencies between case and control groups, the RA patient with the GT haplotype appeared to be a significant "protective" haplotype compared with other haplotypes (OR: 0.73, 95% CI: 0.59-0.91; p = 0.005). Furthermore, the increased serum level of EGFR was also observed in RA patients (p ˂ 0.001).Our study showed that RA is associated with rs17337023 SNP in EGFR gene and increased serum level of the EGFR protein. These findings suggest EGFR is worthy of further investigation as a therapeutic target for RA. We have previously described the association of rheumatoid arthritis (RA) prevalence and two epidermal growth factor receptor (EGFR) SNPs (rs17337023 and rs2227983) among the Taiwanese population. This present study aimed to elucidate whether the SNPs can alter the expression of EGFR in the progression of RA. The cohort study included 366 Taiwan's Han Chinese RA patients and 326 age and gender matched healthy controls. Blood samples collected from the participants were analyzed to determine their serum EGFR levels and to identify EGFR SNPs from their genomic DNA. Genotyping for EGFR SNPs was performed by restriction fragment length polymorphism (RFLP) assay. The relationship between EGFR SNP and the clinical manifestations of RA was evaluated. Our results showed that a statistically significant difference in genotype frequency distributions at rs17337023 SNP for RA patients and controls (p ˂ 0.05). In addition, compared with the haplotype frequencies between case and control groups, the RA patient with the GT haplotype appeared to be a significant "protective" haplotype compared with other haplotypes (OR: 0.73, 95% CI: 0.59-0.91; p = 0.005). Furthermore, the increased serum level of EGFR was also observed in RA patients (p ˂ 0.001). Our study showed that RA is associated with rs17337023 SNP in EGFR gene and increased serum level of the EGFR protein. These findings suggest EGFR is worthy of further investigation as a therapeutic target for RA. Objective We have previously described the association of rheumatoid arthritis (RA) prevalence and two epidermal growth factor receptor (EGFR) SNPs (rs17337023 and rs2227983) among the Taiwanese population. This present study aimed to elucidate whether the SNPs can alter the expression of EGFR in the progression of RA. Methods The cohort study included 366 Taiwan’s Han Chinese RA patients and 326 age and gender matched healthy controls. Blood samples collected from the participants were analyzed to determine their serum EGFR levels and to identify EGFR SNPs from their genomic DNA. Genotyping for EGFR SNPs was performed by restriction fragment length polymorphism (RFLP) assay. The relationship between EGFR SNP and the clinical manifestations of RA was evaluated. Results Our results showed that a statistically significant difference in genotype frequency distributions at rs17337023 SNP for RA patients and controls (p ˂ 0.05). In addition, compared with the haplotype frequencies between case and control groups, the RA patient with the GT haplotype appeared to be a significant “protective” haplotype compared with other haplotypes (OR: 0.73, 95% CI: 0.59–0.91; p = 0.005). Furthermore, the increased serum level of EGFR was also observed in RA patients (p ˂ 0.001). Conclusion Our study showed that RA is associated with rs17337023 SNP in EGFR gene and increased serum level of the EGFR protein. These findings suggest EGFR is worthy of further investigation as a therapeutic target for RA. |
| Audience | Academic |
| Author | Huang, Yu-Chuen Chen, Shih-Yin Chang, Yuan-Yen Chen, Hsin-Han Liu, Shih-Ping Lin, Ying-Ju Lin, Hui-Wen Chen, Da-Chung Tsai, Fuu-Jen Huang, Chung-Ming |
| AuthorAffiliation | 2 Division of Immunology and Rheumatology, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan 8 Department of Optometry, Asia University, Taichung, Taiwan 9 Department of Pediatrics, China Medical University Hospital, Taichung, Taiwan 1 School of Chinese Medicine, China Medical University, Taichung, Taiwan 5 Genetics Center, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan 7 Department of Microbiology and Immunology, and Institute of Microbiology and Immunology, School of Medicine, Chung Shan Medical University, Taichung, Taiwan 3 Division of Plastic and Reconstructive Surgery, China Medical University Hospital, Taichung, Taiwan 6 Center for Neuropsychiatry, China Medical University Hospital, Taichung, Taiwan Children's National Health System, UNITED STATES 4 Taiwan LandSeed Hospital, Pingjen City, Taoyuan, Taiwan 10 Department of Medical Genetics, China Medical University Hospital, Taichung, Taiwan |
| AuthorAffiliation_xml | – name: Children's National Health System, UNITED STATES – name: 1 School of Chinese Medicine, China Medical University, Taichung, Taiwan – name: 2 Division of Immunology and Rheumatology, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan – name: 3 Division of Plastic and Reconstructive Surgery, China Medical University Hospital, Taichung, Taiwan – name: 4 Taiwan LandSeed Hospital, Pingjen City, Taoyuan, Taiwan – name: 5 Genetics Center, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan – name: 8 Department of Optometry, Asia University, Taichung, Taiwan – name: 6 Center for Neuropsychiatry, China Medical University Hospital, Taichung, Taiwan – name: 9 Department of Pediatrics, China Medical University Hospital, Taichung, Taiwan – name: 7 Department of Microbiology and Immunology, and Institute of Microbiology and Immunology, School of Medicine, Chung Shan Medical University, Taichung, Taiwan – name: 10 Department of Medical Genetics, China Medical University Hospital, Taichung, Taiwan |
| Author_xml | – sequence: 1 givenname: Chung-Ming surname: Huang fullname: Huang, Chung-Ming – sequence: 2 givenname: Hsin-Han surname: Chen fullname: Chen, Hsin-Han – sequence: 3 givenname: Da-Chung surname: Chen fullname: Chen, Da-Chung – sequence: 4 givenname: Yu-Chuen surname: Huang fullname: Huang, Yu-Chuen – sequence: 5 givenname: Shih-Ping surname: Liu fullname: Liu, Shih-Ping – sequence: 6 givenname: Ying-Ju surname: Lin fullname: Lin, Ying-Ju – sequence: 7 givenname: Yuan-Yen surname: Chang fullname: Chang, Yuan-Yen – sequence: 8 givenname: Hui-Wen surname: Lin fullname: Lin, Hui-Wen – sequence: 9 givenname: Shih-Yin surname: Chen fullname: Chen, Shih-Yin – sequence: 10 givenname: Fuu-Jen surname: Tsai fullname: Tsai, Fuu-Jen |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/28700691$$D View this record in MEDLINE/PubMed |
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| Snippet | We have previously described the association of rheumatoid arthritis (RA) prevalence and two epidermal growth factor receptor (EGFR) SNPs (rs17337023 and... Objective We have previously described the association of rheumatoid arthritis (RA) prevalence and two epidermal growth factor receptor (EGFR) SNPs (rs17337023... Objective We have previously described the association of rheumatoid arthritis (RA) prevalence and two epidermal growth factor receptor (EGFR) SNPs (rs17337023... |
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| SubjectTerms | Adult Aged Arthritis Arthritis, Rheumatoid - blood Arthritis, Rheumatoid - genetics Biology and Life Sciences Chi-Square Distribution Clinical trials Deoxyribonucleic acid Development and progression DNA Enzyme-Linked Immunosorbent Assay Epidermal growth factor Epidermal growth factor receptors Female Fibroblasts Gene expression Gene Frequency - genetics Gene polymorphism Genetic aspects Genetic Predisposition to Disease - genetics Genetics Genotype Genotyping Haplotypes Haplotypes - genetics Hospitals Humans Immunology Inflammation Ligands Male Medical research Medicine Medicine and Health Sciences Middle Aged Patients People and Places Polymerase chain reaction Polymorphism Polymorphism, Restriction Fragment Length - genetics Polymorphism, Single Nucleotide - genetics Population Population studies Proteins Receptor, Epidermal Growth Factor - blood Receptor, Epidermal Growth Factor - genetics Research and Analysis Methods Restriction fragment length polymorphism Rheumatoid arthritis Rheumatology Rodents Signal transduction Single nucleotide polymorphisms Single-nucleotide polymorphism Statistical analysis Statistical methods |
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| Title | Rheumatoid arthritis is associated with rs17337023 polymorphism and increased serum level of the EGFR protein |
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