4-Hydroxy hexenal derived from docosahexaenoic acid protects endothelial cells via Nrf2 activation

• Published in: PloS one Vol. 8; no. 7; p. e69415
• Main Authors: Ishikado, Atsushi, Morino, Katsutaro, Nishio, Yoshihiko, Nakagawa, Fumiyuki, Mukose, Atsushi, Sono, Yoko, Yoshioka, Nagisa, Kondo, Keiko, Sekine, Osamu, Yoshizaki, Takeshi, Ugi, Satoshi, Uzu, Takashi, Kawai, Hiromichi, Makino, Taketoshi, Okamura, Tomio, Yamamoto, Masayuki, Kashiwagi, Atsunori, Maegawa, Hiroshi
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 23.07.2013; Public Library of Science (PLoS)
• Subjects: Activation; Adaptor Proteins, Signal Transducing - metabolism; Aldehydes - metabolism; Aldehydes - pharmacology; Animals; Antioxidants; Antioxidants (Nutrients); Antioxidants - pharmacology; Aorta; Aorta - drug effects; Aorta - physiology; Atherosclerosis; Bioassays; Biological assays; Biology; Body Weight - drug effects; Cellular manufacture; Cytoprotection - drug effects; Damage prevention; Deoxyribonucleic acid; Diabetes; Diet; DNA; DNA Damage; Docosahexaenoic acid; Docosahexaenoic Acids - chemistry; Eicosapentaenoic acid; Eicosapentaenoic Acid - chemistry; Endothelial cells; Endothelial Cells - cytology; Endothelial Cells - drug effects; Endothelial Cells - metabolism; Endothelium; Enzymes; Fatty acids; Fish oils; Gene expression; Gene Expression Regulation - drug effects; Genes; Glutamate-Cysteine Ligase - metabolism; Heme; Heme oxygenase (decyclizing); Heme Oxygenase-1 - metabolism; House mouse; Human Umbilical Vein Endothelial Cells - cytology; Human Umbilical Vein Endothelial Cells - drug effects; Human Umbilical Vein Endothelial Cells - enzymology; Humans; Inflammation; Laboratories; Lipid Peroxidation - drug effects; Male; Medicine; Metabolism; Metabolites; Mice; Molecular modelling; NF-E2-Related Factor 2 - metabolism; Oils & fats; Omega 3 fatty acids; Oxidation; Oxidation-Reduction - drug effects; Oxidative Stress - drug effects; Oxygen; Oxygenase; Peroxidation; Polyunsaturated fatty acids; R&D; Reactive oxygen species; Reactive Oxygen Species - metabolism; Research & development; Rodents; Science; Sequestosome-1 Protein; siRNA; Studies; Transcription (Genetics); Umbilical vein; Unsaturated fatty acids; Vascular tissue; Vasodilation; Vasodilation - drug effects; Japan

Recent studies have proposed that n-3 polyunsaturated fatty acids (n-3 PUFAs) have direct antioxidant and anti-inflammatory effects in vascular tissue, explaining their cardioprotective effects. However, the molecular mechanisms are not yet fully understood. We tested whether n-3 PUFAs showed antiox...