Healthy Volunteers Can Be Phenotyped Using Cutaneous Sensitization Pain Models

• Published in: PloS one Vol. 8; no. 5; p. e62733
• Main Authors: Werner, Mads U., Petersen, Karin L., Rowbotham, Michael C., Dahl, Jørgen B.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 09.05.2013; Public Library of Science (PLoS)
• Subjects: Analgesics; Analysis; Anesthesiology; Antipruritics - adverse effects; Burns; Burns - complications; Capsaicin; Capsaicin - administration & dosage; Correlation analysis; Correlation coefficient; Correlation coefficients; Forearm; Healthy Volunteers - classification; Heat; Hot Temperature - adverse effects; Humans; Hyperalgesia; Hyperalgesia - classification; Hyperalgesia - etiology; Hyperalgesia - physiopathology; Medicine; Models, Biological; Narcotics; Pain; Pain - classification; Pain - etiology; Pain - physiopathology; Pain Measurement - methods; Pain Measurement - statistics & numerical data; Pain perception; Pharmacodynamics; Pharmacology; Phenotyping; Reproducibility of Results; Skin - drug effects; Skin - physiopathology; Statistical methods; Studies; Thigh; Volunteers; United States > US; San Francisco California; California

Human experimental pain models leading to development of secondary hyperalgesia are used to estimate efficacy of analgesics and antihyperalgesics. The ability to develop an area of secondary hyperalgesia varies substantially between subjects, but little is known about the agreement following repeate...