Combining urine lipoarabinomannan with antibody detection as a simple non-sputum-based screening method for HIV-associated tuberculosis

• Published in: PloS one Vol. 14; no. 6; p. e0218606
• Main Authors: Younis, Hiba, Kerschbaumer, Isabell, Moon, Jee-Young, Kim, Ryung S, Blanc, Caroline J, Chen, Tingting, Wood, Robin, Lawn, Steven, Achkar, Jacqueline M
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 25.06.2019; Public Library of Science (PLoS)
• Subjects: Adult; Antibodies; Antibodies, Bacterial - blood; Antiretroviral agents; Antiretroviral drugs; Antiretroviral therapy; Arabinomannan; Biology and Life Sciences; Biomarkers; Care and treatment; Diagnosis; Diagnostic systems; Enzymes; Epidemiology; Female; Highly active antiretroviral therapy; HIV; HIV infections; HIV Infections - complications; HIV patients; HIV tests; Human immunodeficiency virus; Humans; Immunoglobulin G; Immunoglobulin M; Infectious diseases; Lipopolysaccharides - immunology; Lipopolysaccharides - urine; Male; Medical diagnosis; Medical research; Medical schools; Medical tests; Medicine; Medicine and Health Sciences; Microscopy; Patient outcomes; Proteins; Regression analysis; Regression models; Screening; Sensitivity; Sensitivity and Specificity; Serologic Tests - methods; South Africa; Sputum; Tuberculosis; Tuberculosis - blood; Tuberculosis - diagnosis; Tuberculosis - etiology; Tuberculosis - urine; Tutu, Desmond; Urine; South Africa; New York; United States > US

Simple methods for the accurate triaging and screening of HIV-associated tuberculosis (TB) are urgently needed. We hypothesized that combining serum antibody with urine lipoarabinomannan (U-LAM) detection can improve the detection of HIV-associated TB. We performed a case-control study with sampling...