Tumor Necrosis Factor, but Not Neutrophils, Alters the Metabolic Profile in Acute Experimental Arthritis

• Published in: PloS one Vol. 11; no. 1; p. e0146403
• Main Authors: Oliveira, Marina C, Tavares, Luciana P, Vago, Juliana P, Batista, Nathália V, Queiroz-Junior, Celso M, Vieira, Angelica T, Menezes, Gustavo B, Sousa, Lirlândia P, van de Loo, Fons A J, Teixeira, Mauro M, Amaral, Flávio A, Ferreira, Adaliene V M
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 07.01.2016; Public Library of Science (PLoS)
• Subjects: Adipokines - genetics; Adipokines - metabolism; Animals; Anti-Inflammatory Agents, Non-Steroidal - pharmacology; Antibodies, Monoclonal - pharmacology; Antigens; Arthritis; Arthritis, Experimental - chemically induced; Arthritis, Experimental - drug therapy; Arthritis, Experimental - metabolism; Arthritis, Experimental - pathology; Biochemistry; Bovine serum albumin; C-Reactive Protein - genetics; C-Reactive Protein - metabolism; Care and treatment; Cartilage, Articular - drug effects; Cartilage, Articular - metabolism; Cartilage, Articular - pathology; Cattle; Chemokines; Cytokines; Disease; Etanercept; Etanercept - pharmacology; Gene Expression; Glucose; Glucose - metabolism; Immunization; Immunology; Inflammation; Injections, Intra-Articular; Insulin resistance; Knee; Leukocytes (neutrophilic); Lipid metabolism; Lipid Metabolism - drug effects; Lipids; Male; Metabolism; Metabolites; Mice; Mice, Inbred BALB C; Microscopy; Monoclonal antibodies; Necrosis; Nerve Tissue Proteins - genetics; Nerve Tissue Proteins - metabolism; Neutrophil Infiltration - drug effects; Neutrophils; Neutrophils - drug effects; Neutrophils - metabolism; Neutrophils - pathology; Nursing schools; Obesity; Pain perception; Pharmacy; Receptors, Interleukin-8A - antagonists & inhibitors; Receptors, Interleukin-8A - genetics; Receptors, Interleukin-8A - metabolism; Receptors, Interleukin-8B - antagonists & inhibitors; Receptors, Interleukin-8B - genetics; Receptors, Interleukin-8B - metabolism; Rheumatoid arthritis; Risk factors; Rodents; Serum albumin; Serum Albumin, Bovine; Sulfonamides - pharmacology; Tumor necrosis factor; Tumor Necrosis Factor-alpha - antagonists & inhibitors; Tumor Necrosis Factor-alpha - genetics; Tumor Necrosis Factor-alpha - metabolism; Tumor necrosis factor-TNF; Tumors; Brazil

Metabolic alterations are associated with arthritis apart from obesity. However, it is still unclear which is the underlying process behind these metabolic changes. Here, we investigate the role of tumor necrosis factor (TNF) in this process in an acute model of antigen-induced arthritis (AIA). Immu...