Proteomic Profiling of Bronchoalveolar Lavage Fluid in Critically Ill Patients with Ventilator-Associated Pneumonia

• Published in: PloS one Vol. 8; no. 3; p. e58782
• Main Authors: Nguyen, Elizabeth V., Gharib, Sina A., Palazzo, Steven J., Chow, Yu-hua, Goodlett, David R., Schnapp, Lynn M.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 07.03.2013; Public Library of Science (PLoS)
• Subjects: Actinin; Adult; Adult respiratory distress syndrome; Aged; Aged, 80 and over; Algorithms; Alveoli; Analysis; Annotations; Biology; Biomarkers; Bronchoalveolar lavage; Bronchoalveolar Lavage Fluid - chemistry; Bronchus; Case-Control Studies; Cluster Analysis; Computer applications; Critical care; Critical Illness; Female; Functional analysis; Gene expression; Gene Expression Regulation; Health aspects; Humans; Identification methods; Inflammation; Lungs; Male; Mass spectrometry; Mass spectroscopy; Medicine; Middle Aged; Morbidity; Mortality; Network analysis; Neutrophils; Patients; Peptides; Pharmaceutical sciences; Pneumonia; Pneumonia, Ventilator-Associated - genetics; Pneumonia, Ventilator-Associated - metabolism; Protein Interaction Mapping; Protein Interaction Maps; Proteins; Proteome; Proteomics; Pulmonary arteries; Reproducibility of Results; Shotguns; Statistical methods; Target recognition; Ventilator-associated pneumonia; Ventilators; Young Adult; United States > US
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0058782

Ventilator-associated pneumonia (VAP) is a common complication in patients with acute lung injury (ALI) and can lead to increased morbidity and mortality. Identifying protein profiles specific to VAP in bronchoalveolar lavage fluid (BALF) may aid in earlier diagnosis, elucidate mechanisms of disease...