Delay in development and behavioural abnormalities in the absence of p53 in zebrafish

• Published in: PloS one Vol. 14; no. 7; p. e0220069
• Main Authors: Elabd, Seham, Jabeen, Nuzhat Amna, Gerber, Vanessa, Peravali, Ravindra, Bourdon, Jean-Christoph, Kancherla, Shilpa, Vallone, Daniela, Blattner, Christine
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 19.07.2019; Public Library of Science (PLoS)
• Subjects: Abnormalities; Animals; Animals, Genetically Modified; Apoptosis; Behavior, Animal; Biology and Life Sciences; Biomarkers; Body size; Cancer; Cell cycle; Cell differentiation; Cell Line; Cell proliferation; CRISPR; CRISPR-Cas technology; Danio rerio; Deoxyribonucleic acid; DNA; DNA damage; Embryo, Nonmammalian; Embryogenesis; Embryonic development; Embryonic growth stage; Embryos; Gene Expression Regulation, Developmental; Genes; Genetic Loci; Genomes; Hatching; Larva; Larvae; Latency; Locomotion; Mental disorders; p53 Protein; Physical Sciences; Pigmentation; Proteins; Research and Analysis Methods; Siblings; Stem cells; Toxicology; Tumor proteins; Tumor Suppressor Protein p53 - genetics; Tumor Suppressor Protein p53 - metabolism; Tumors; Vibration; Zebrafish; Zebrafish - physiology; Germany

p53 is well-known for its tumour-suppressive activity. However, in the past decade it became clear that p53 is also involved in other processes including stem cell proliferation, differentiation and animal development. To investigate the role of p53 in early embryonic development, we targeted p53 by...