An Increased Abundance of Tumor-Infiltrating Regulatory T Cells Is Correlated with the Progression and Prognosis of Pancreatic Ductal Adenocarcinoma

• Published in: PloS one Vol. 9; no. 3; p. e91551
• Main Authors: Tang, Yichen, Xu, Xuejun, Guo, Shixiang, Zhang, Chaobin, Tang, Yan, Tian, Yi, Ni, Bing, Lu, Binfeng, Wang, Huaizhi
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 17.03.2014; Public Library of Science (PLoS)
• Subjects: Abundance; Adenocarcinoma; Adult; Aged; Antigens; Biology and Life Sciences; Cancer therapies; Carcinoma, Pancreatic Ductal - immunology; Carcinoma, Pancreatic Ductal - mortality; Carcinoma, Pancreatic Ductal - pathology; Case-Control Studies; CD25 antigen; CD4 antigen; CD8 antigen; CD8-Positive T-Lymphocytes - immunology; CD8-Positive T-Lymphocytes - metabolism; Colorectal cancer; Comparative analysis; Correlation; Cytokines; Cytometry; Cytotoxicity; Disease Progression; Epithelial cells; Female; Flow cytometry; Forkhead Transcription Factors - metabolism; Foxp3 protein; Hospitals; Humans; Immunity; Immunology; Immunophenotyping; Immunoregulation; Immunosuppression; Immunotherapy; Leukocytes (mononuclear); Liver cancer; Lymphocyte Count; Lymphocytes; Lymphocytes T; Lymphocytes, Tumor-Infiltrating - immunology; Lymphocytes, Tumor-Infiltrating - metabolism; Male; Medical prognosis; Medical research; Medicine and Health Sciences; Middle Aged; Neoplasm Grading; Neoplasm Metastasis; Neoplasm Staging; Ovarian cancer; Pancreas; Pancreatic cancer; Pancreatic Neoplasms - immunology; Pancreatic Neoplasms - mortality; Pancreatic Neoplasms - pathology; Patients; Peripheral blood mononuclear cells; Prognosis; Research and Analysis Methods; Stroma; Studies; Surgery; T cells; T-Lymphocyte Subsets - immunology; T-Lymphocyte Subsets - metabolism; T-Lymphocytes, Regulatory - immunology; T-Lymphocytes, Regulatory - metabolism; Tissues; Tumor Microenvironment; Tumors; China

CD4+CD25+Foxp3+ regulatory T cells (Tregs) can inhibit cytotoxic responses. Though several studies have analyzed Treg frequency in the peripheral blood mononuclear cells (PBMCs) of pancreatic ductal adenocarcinoma (PDA) patients using flow cytometry (FCM), few studies have examined how intratumoral...