Estrous cycle dependent fluctuations of regulatory neuropeptides in the lower urinary tract of female rats upon colon-bladder cross-sensitization

• Published in: PloS one Vol. 9; no. 5; p. e94872
• Main Authors: Pan, Xiao-Qing, Malykhina, Anna P
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.05.2014; Public Library of Science (PLoS)
• Subjects: Animals; Biology and Life Sciences; Bladder; Brain; Brain-derived neurotrophic factor; Brain-Derived Neurotrophic Factor - metabolism; Calcitonin; Calcitonin gene-related peptide; Calcitonin Gene-Related Peptide - metabolism; Colitis; Colitis - chemically induced; Colitis - metabolism; Colon; Colon - metabolism; Control; Estrogens; Estrous Cycle; Estrus cycle; Female; Fluctuations; Ganglia; Ganglia, Spinal - metabolism; Gene expression; Gonadal Steroid Hormones - pharmacology; Growth factors; Hormones; Inflammation; Inflammatory bowel disease; Intestine; Kinases; Medicine and Health Sciences; Morbidity; Nerve growth factor; Nerve Growth Factors - metabolism; Neurons; Neuropeptides; Neuropeptides - metabolism; Neurosciences; Organs; Pain; Peptides; Peroxidase - metabolism; Physiology; Rats; Research and Analysis Methods; Rodent control; Rodents; Sense organs; Sensory neurons; Sex hormones; Spinal cord; Studies; Substance P; Substance P - metabolism; Urinary bladder; Urinary Bladder - metabolism; Urinary tract; Urogenital system; Urology; Uterus; Vagina; Women's health; Pennsylvania

Co-morbidity of bladder, bowel, and non-specific pelvic pain symptoms is highly prevalent in women. Little evidence is present on modulation of pelvic pain syndromes by sex hormones, therefore, the objective of this study was to clarify the effects of hormonal fluctuations within the estrous cycle o...