Assessment of Human Immune Responses to H7 Avian Influenza Virus of Pandemic Potential: Results from a Placebo–Controlled, Randomized Double–Blind Phase I Study of Live Attenuated H7N3 Influenza Vaccine

• Published in: PloS one Vol. 9; no. 2; p. e87962
• Main Authors: Rudenko, Larisa, Kiseleva, Irina, Naykhin, Anatoly N., Erofeeva, Marianna, Stukova, Marina, Donina, Svetlana, Petukhova, Galina, Pisareva, Maria, Krivitskaya, Vera, Grudinin, Michael, Buzitskaya, Zhanna, Isakova–Sivak, Irina, Kuznetsova, Svetlana, Larionova, Natalie, Desheva, Julia, Dubrovina, Irina, Nikiforova, Alexandra, Victor, John C., Neuzil, Kathy, Flores, Jorge, Tsvetnitsky, Vadim, Kiselev, Oleg
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 12.02.2014; Public Library of Science (PLoS)
• Subjects: Adolescent; Adult; Adults; Analysis; Antibodies; Antibodies, Viral - blood; Antigens; Attenuation; Avian flu; Biology; CD4 antigen; CD4-Positive T-Lymphocytes - immunology; CD8 antigen; CD8-Positive T-Lymphocytes - immunology; Clinical trials; Cold Temperature; Developing countries; Double-blind studies; Drug dosages; Eggs; Epidemics; Ethics; Female; Genes; Human behavior; Humans; Immune response; Immune system; Immunization; Immunogenicity; Immunoglobulin A; Immunoglobulin A - blood; Immunoglobulin G; Immunoglobulin G - blood; Immunological memory; Influenza; Influenza A; Influenza A Virus, H7N3 Subtype; Influenza A Virus, H7N9 Subtype; Influenza vaccines; Influenza Vaccines - immunology; Influenza Vaccines - therapeutic use; Influenza, Human - prevention & control; LDCs; Lectins; Lymphocytes; Lymphocytes T; Male; Medicine; Memory cells; Middle Aged; Neutralization Tests; Pandemics; Phylogenetics; Product development; Randomization; Ribonucleic acid; RNA; RNA viruses; Safety; Shedding; Swine flu; T cells; Vaccination; Vaccines; Vaccines, Attenuated - immunology; Vaccines, Attenuated - therapeutic use; Virology; Virus Replication; Viruses; Young Adult
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0087962

Live attenuated influenza vaccines (LAIVs) are being developed to protect humans against future epidemics and pandemics. This study describes the results of a double-blinded randomized placebo-controlled phase I clinical trial of cold-adapted and temperature sensitive H7N3 live attenuated influenza...