A review of methods for addressing components of interventions in meta-analysis

Many healthcare interventions are complex, consisting of multiple, possibly interacting, components. Several methodological articles addressing complex interventions in the meta-analytical context have been published. We hereby provide an overview of methods used to evaluate the effects of complex i...

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Published inPloS one Vol. 16; no. 2; p. e0246631
Main Authors Petropoulou, Maria, Efthimiou, Orestis, Rücker, Gerta, Schwarzer, Guido, Furukawa, Toshi A., Pompoli, Alessandro, Koek, Huiberdina L., Del Giovane, Cinzia, Rodondi, Nicolas, Mavridis, Dimitris
Format Journal Article
LanguageEnglish
Published United States Public Library of Science 08.02.2021
Public Library of Science (PLoS)
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Abstract Many healthcare interventions are complex, consisting of multiple, possibly interacting, components. Several methodological articles addressing complex interventions in the meta-analytical context have been published. We hereby provide an overview of methods used to evaluate the effects of complex interventions with meta-analytical models. We summarized the methodology, highlighted new developments, and described the benefits, drawbacks, and potential challenges of each identified method. We expect meta-analytical methods focusing on components of several multicomponent interventions to become increasingly popular due to recently developed, easy-to-use, software tools that can be used to conduct the relevant analyses. The different meta-analytical methods are illustrated through two examples comparing psychotherapies for panic disorder.
AbstractList Many healthcare interventions are complex, consisting of multiple, possibly interacting, components. Several methodological articles addressing complex interventions in the meta-analytical context have been published. We hereby provide an overview of methods used to evaluate the effects of complex interventions with meta-analytical models. We summarized the methodology, highlighted new developments, and described the benefits, drawbacks, and potential challenges of each identified method. We expect meta-analytical methods focusing on components of several multicomponent interventions to become increasingly popular due to recently developed, easy-to-use, software tools that can be used to conduct the relevant analyses. The different meta-analytical methods are illustrated through two examples comparing psychotherapies for panic disorder.
Many healthcare interventions are complex, consisting of multiple, possibly interacting, components. Several methodological articles addressing complex interventions in the meta-analytical context have been published. We hereby provide an overview of methods used to evaluate the effects of complex interventions with meta-analytical models. We summarized the methodology, highlighted new developments, and described the benefits, drawbacks, and potential challenges of each identified method. We expect meta-analytical methods focusing on components of several multicomponent interventions to become increasingly popular due to recently developed, easy-to-use, software tools that can be used to conduct the relevant analyses. The different meta-analytical methods are illustrated through two examples comparing psychotherapies for panic disorder.Many healthcare interventions are complex, consisting of multiple, possibly interacting, components. Several methodological articles addressing complex interventions in the meta-analytical context have been published. We hereby provide an overview of methods used to evaluate the effects of complex interventions with meta-analytical models. We summarized the methodology, highlighted new developments, and described the benefits, drawbacks, and potential challenges of each identified method. We expect meta-analytical methods focusing on components of several multicomponent interventions to become increasingly popular due to recently developed, easy-to-use, software tools that can be used to conduct the relevant analyses. The different meta-analytical methods are illustrated through two examples comparing psychotherapies for panic disorder.
Audience Academic
Author Koek, Huiberdina L.
Del Giovane, Cinzia
Rodondi, Nicolas
Efthimiou, Orestis
Petropoulou, Maria
Mavridis, Dimitris
Rücker, Gerta
Schwarzer, Guido
Furukawa, Toshi A.
Pompoli, Alessandro
AuthorAffiliation 4 Department of Psychiatry, University of Oxford, Oxford, United Kingdom
11 Faculté de Médecine, Paris Descartes University, Sorbonne Paris Cité, Paris, France
1 Faculty of Medicine and Medical Center, Institute of Medical Biometry and Statistics, University of Freiburg, Freiburg, Germany
2 Department of Primary Education, Evidence Synthesis Methods Team, University of Ioannina, Ioannina, Greece
8 Institute of Primary Health Care (BIHAM), University of Bern, Bern, Switzerland
Witten/Herdecke University, GERMANY
6 Psychiatric Rehabilitation Clinic Villa San Pietro, Trento, Italy
3 Institute of Social and Preventive Medicine (ISPM), University of Bern, Bern, Switzerland
9 Population Health Laboratory (#PopHealthLab), University of Fribourg, Fribourg, Switzerland
10 Department of General Internal Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
5 Departments of Health Promotion and Human Behavior and Clinical Epidemiology, Kyoto University Graduate School of Me
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Cites_doi 10.1136/bmj.328.7455.1561
10.1016/j.jclinepi.2013.06.005
10.1136/bmjgh-2018-000840
10.1111/rssa.12018
10.1186/s13063-016-1238-z
10.1016/j.jclinepi.2012.07.012
10.1016/j.cardfail.2016.06.422
10.1016/j.jclinepi.2017.01.004
10.1177/0163278717709562
10.1016/0140-6736(93)93004-K
10.2147/CLEP.S16235
10.1161/CIRCULATIONAHA.115.018006
10.1002/jrsm.1058
10.1016/j.jclinepi.2017.06.011
10.1016/j.jclinepi.2018.02.012
10.1136/bmjgh-2018-001107
10.1192/bjp.bp.106.023655
10.1016/j.jclinepi.2017.11.018
10.1186/1471-2288-3-26
10.1136/bmjgh-2018-000893
10.1002/jrsm.1160
10.1016/j.jclinepi.2013.07.003
10.1016/j.jclinepi.2013.09.003
10.1016/j.jclinepi.2017.06.017
10.1016/j.jclinepi.2013.06.014
10.1093/eurpub/ckr084
10.1016/j.jclinepi.2013.05.013
10.1023/A:1008929526011
10.1002/bimj.201800167
10.1136/bmjgh-2018-000882
10.1016/j.jclinepi.2017.06.012
10.1016/j.jclinepi.2017.06.016
10.1016/j.jclinepi.2013.06.017
10.1146/annurev-publhealth-040617-014112
10.1016/j.jclinepi.2017.06.014
10.1136/bmj.c221
10.1136/bmjgh-2018-000848
10.1136/eb-2015-102275
10.1017/S0033291717003919
10.1002/sim.5726
10.1136/bmjgh-2018-000858
10.1016/j.jclinepi.2013.06.013
10.1136/bmj.a1655
10.1093/aje/kwp014
10.1183/13993003.01860-2015
10.1016/j.jclinepi.2013.06.004
10.1371/journal.pone.0086754
10.1002/sim.1187
10.1016/j.jclinepi.2016.11.002
10.1016/j.jclinepi.2017.06.013
10.1001/jama.2017.15006
10.2147/COPD.S107884
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2021 Petropoulou et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
2021 Petropoulou et al 2021 Petropoulou et al
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– notice: 2021 Petropoulou et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
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References T Pigott (pone.0246631.ref013) 2013; 66
Α Thomas (pone.0246631.ref058) 2006; 6
Complex Interventions Workgroup (pone.0246631.ref018) 2017; 90
G Rücker (pone.0246631.ref060) 2020
EE Tanner-Smith (pone.0246631.ref037) 2018; 39
AC Tricco (pone.0246631.ref052) 2017; 318
SI Bangdiwala (pone.0246631.ref031) 2018; 41
NH Jonkman (pone.0246631.ref051) 2016; 22
L Stewart (pone.0246631.ref045) 1993; 341
A Booth (pone.0246631.ref019) 2019; 4
A Booth (pone.0246631.ref025) 2019; 4
JE Squires (pone.0246631.ref009) 2013; 66
NH Jonkman (pone.0246631.ref029) 2017; 83
NH Jonkman (pone.0246631.ref048) 2016; 133
J Noyes (pone.0246631.ref005) 2013; 66
JPT Higgins (pone.0246631.ref023) 2019; 4
A James (pone.0246631.ref062) 2018; 97
AA Montgomery (pone.0246631.ref026) 2003; 3
GetReal Methods Review Group (pone.0246631.ref046) 2015; 6
SG Thompson (pone.0246631.ref040) 2002; 21
A Nikolakopoulou (pone.0246631.ref053) 2014; 9
Complex Interventions Workgroup (pone.0246631.ref017) 2017; 90
J Madan (pone.0246631.ref030) 2014; 177
P Bower (pone.0246631.ref042) 2006; 189
RD Riley (pone.0246631.ref044) 2010; 340
Μ Petticrew (pone.0246631.ref002) 2011; 21
TA Furukawa (pone.0246631.ref039) 2007
B Burford (pone.0246631.ref011) 2013; 66
G Rücker (pone.0246631.ref055) 2012; 3
NH Jonkman (pone.0246631.ref050) 2016; 48
EJ Mills (pone.0246631.ref035) 2012; 65
M Petticrew (pone.0246631.ref020) 2019; 4
DJ Lunn (pone.0246631.ref057) 2000; 10
G Rücker (pone.0246631.ref038) 2020
M Viswanathan (pone.0246631.ref016) 2017; 90
SC Freeman (pone.0246631.ref032) 2018; 98
LM Anderson (pone.0246631.ref007) 2013; 66
M Butler (pone.0246631.ref015) 2017; 90
P Hawe (pone.0246631.ref003) 2004; 328
M Petticrew (pone.0246631.ref001) 2013; 66
MP Kelly (pone.0246631.ref012) 2017; 90
M Petropoulou (pone.0246631.ref028) 2017; 82
R Development Core Team (pone.0246631.ref061) 2018
G Rücker (pone.0246631.ref033) 2020; 62
pone.0246631.ref059
P Craig (pone.0246631.ref004) 2008; 337
JM Guise (pone.0246631.ref014) 2017; 90
P Montgomery (pone.0246631.ref024) 2019; 4
NJ Welton (pone.0246631.ref027) 2009; 169
DM Caldwell (pone.0246631.ref036) 2016; 19
EJ Mills (pone.0246631.ref056) 2011; 3
K Thorlund (pone.0246631.ref034) 2012; 4
ΑΑ Veroniki (pone.0246631.ref047) 2016; 17
NH Jonkman (pone.0246631.ref049) 2016; 11
RD Riley (pone.0246631.ref043) 2013; 32
P Tugwell (pone.0246631.ref008) 2013; 66
M Petticrew (pone.0246631.ref006) 2013; 66
K Flemming (pone.0246631.ref022) 2019; 4
G Schwarzer (pone.0246631.ref041) 2007; 7
A Pompoli (pone.0246631.ref054) 2018; 48
T Pigott (pone.0246631.ref010) 2013; 66
J Noyes (pone.0246631.ref021) 2019; 4
References_xml – volume: 328
  start-page: 1561
  issue: 7455
  year: 2004
  ident: pone.0246631.ref003
  article-title: Complex interventions: how ‘out of control’ can a randomised controlled trial be?
  publication-title: BMJ
  doi: 10.1136/bmj.328.7455.1561
– volume: 66
  start-page: 1230
  issue: 11
  year: 2013
  ident: pone.0246631.ref006
  article-title: Synthesizing evidence on complex interventions: how meta-analytical, qualitative, and mixed-method approaches can contribute
  publication-title: J. Clin. Epidemiol
  doi: 10.1016/j.jclinepi.2013.06.005
– volume: 4
  start-page: e000840
  issue: Suppl 1
  year: 2019
  ident: pone.0246631.ref025
  article-title: Taking account of context in systematic reviews and guidelines considering a complexity perspective
  publication-title: BMJ Glob. Health
  doi: 10.1136/bmjgh-2018-000840
– volume: 177
  start-page: 295
  issue: 1
  year: 2014
  ident: pone.0246631.ref030
  article-title: Synthesis of evidence on heterogeneous interventions with multiple outcomes recorded over multiple follow-up times reported inconsistently: a smoking cessation case-study
  publication-title: J. R. Stat. Soc. Ser. A Stat. Soc
  doi: 10.1111/rssa.12018
– volume: 17
  start-page: 138
  issue: 1
  year: 2016
  ident: pone.0246631.ref047
  article-title: Contacting authors to retrieve individual patient data: study protocol for a randomized controlled trial
  publication-title: Trials
  doi: 10.1186/s13063-016-1238-z
– volume: 65
  start-page: 1282
  issue: 12
  year: 2012
  ident: pone.0246631.ref035
  article-title: Calculating additive treatment effects from multiple randomized trials provides useful estimates of combination therapies
  publication-title: J. Clin. Epidemiol
  doi: 10.1016/j.jclinepi.2012.07.012
– volume: 22
  start-page: 861
  issue: 11
  year: 2016
  ident: pone.0246631.ref051
  article-title: What Are Effective Program Characteristics of Self-Management Interventions in Patients With Heart Failure? An Individual Patient Data Meta-analysis
  publication-title: J. Card. Fail
  doi: 10.1016/j.cardfail.2016.06.422
– volume: 83
  start-page: 48
  year: 2017
  ident: pone.0246631.ref029
  article-title: Complex self-management interventions in chronic disease unravelled: a review of lessons learned from an individual patient data meta-analysis
  publication-title: J. Clin. Epidemiol
  doi: 10.1016/j.jclinepi.2017.01.004
– volume: 41
  start-page: 435
  issue: 4
  year: 2018
  ident: pone.0246631.ref031
  article-title: Evaluating the Effectiveness of Complex, Multi-component, Dynamic, Community-Based Injury Prevention Interventions: A Statistical Framework
  publication-title: Eval. Health Prof
  doi: 10.1177/0163278717709562
– volume: 341
  start-page: 418
  issue: 8842
  year: 1993
  ident: pone.0246631.ref045
  article-title: Meta-analysis of the literature or of individual patient data: is there a difference?
  publication-title: The Lancet
  doi: 10.1016/0140-6736(93)93004-K
– volume: 4
  start-page: e000899
  issue: Suppl 1
  year: 2019
  ident: pone.0246631.ref020
  article-title: Implications of a complexity perspective for systematic reviews and guideline development in health decision making BMJ Glob
  publication-title: Health
– volume: 3
  start-page: 107
  year: 2011
  ident: pone.0246631.ref056
  article-title: Pharmacotherapies for chronic obstructive pulmonary disease: a multiple treatment comparison meta-analysis
  publication-title: Clin. Epidemiol.
  doi: 10.2147/CLEP.S16235
– volume: 133
  start-page: 1189
  issue: 12
  year: 2016
  ident: pone.0246631.ref048
  article-title: Do Self-Management Interventions Work in Patients With Heart Failure? An Individual Patient Data Meta-Analysis
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.115.018006
– volume: 3
  start-page: 312
  issue: 4
  year: 2012
  ident: pone.0246631.ref055
  article-title: Network meta-analysis, electrical networks and graph theory
  publication-title: Res Synth Methods
  doi: 10.1002/jrsm.1058
– volume: 90
  start-page: 6
  year: 2017
  ident: pone.0246631.ref014
  article-title: AHRQ series on complex intervention systematic reviews-paper 1: an introduction to a series of articles that provide guidance and tools for reviews of complex interventions
  publication-title: J. Clin. Epidemiol
  doi: 10.1016/j.jclinepi.2017.06.011
– volume: 98
  start-page: 105
  year: 2018
  ident: pone.0246631.ref032
  article-title: Cooper NJ. Component network meta-analysis identifies the most effective components of psychological preparation for adults undergoing surgery under general anaesthesia
  publication-title: J. Clin. Epidemiol
  doi: 10.1016/j.jclinepi.2018.02.012
– volume: 4
  start-page: e001107
  issue: Suppl 1
  year: 2019
  ident: pone.0246631.ref019
  article-title: Formulating questions to explore complex interventions within qualitative evidence synthesis
  publication-title: BMJ Glob. Health
  doi: 10.1136/bmjgh-2018-001107
– volume: 189
  start-page: 484
  issue: 6
  year: 2006
  ident: pone.0246631.ref042
  article-title: Collaborative care for depression in primary care: Making sense of a complex intervention: systematic review and meta-regression
  publication-title: Br. J. Psychiatry
  doi: 10.1192/bjp.bp.106.023655
– volume: 97
  start-page: 95
  year: 2018
  ident: pone.0246631.ref062
  article-title: Node-making process in network meta-analysis of nonpharmacological treatment are poorly reported
  publication-title: J. Clin. Epidemiol
  doi: 10.1016/j.jclinepi.2017.11.018
– volume: 3
  start-page: 26
  issue: 1
  year: 2003
  ident: pone.0246631.ref026
  article-title: Design, analysis and presentation of factorial randomised controlled trials
  publication-title: BMC Med. Res. Methodol
  doi: 10.1186/1471-2288-3-26
– volume: 4
  start-page: e000893
  issue: Suppl 1
  year: 2019
  ident: pone.0246631.ref021
  article-title: Synthesising quantitative and qualitative evidence to inform guidelines on complex interventions: clarifying the purposes, designs and outlining some methods
  publication-title: BMJ Glob. Health
  doi: 10.1136/bmjgh-2018-000893
– volume: 6
  start-page: 293
  issue: 4
  year: 2015
  ident: pone.0246631.ref046
  article-title: Get real in individual participant data (IPD) meta-analysis: a review of the methodology
  publication-title: Res. Synth. Methods
  doi: 10.1002/jrsm.1160
– volume: 66
  start-page: 1262
  issue: 11
  year: 2013
  ident: pone.0246631.ref005
  article-title: A research and development agenda for systematic reviews that ask complex questions about complex interventions
  publication-title: J. Clin. Epidemiol
  doi: 10.1016/j.jclinepi.2013.07.003
– volume: 66
  start-page: 1195
  issue: 11
  year: 2013
  ident: pone.0246631.ref008
  article-title: Complex interventions–how should systematic reviews of their impact differ from reviews of simple or complicated interventions?
  publication-title: J. Clin. Epidemiol
  doi: 10.1016/j.jclinepi.2013.09.003
– volume: 90
  start-page: 51
  year: 2017
  ident: pone.0246631.ref018
  article-title: AHRQ series on complex intervention systematic reviews-paper 7: PRISMA-CI elaboration and explanation
  publication-title: J. Clin. Epidemiol
  doi: 10.1016/j.jclinepi.2017.06.017
– volume-title: Version 3.5.1
  year: 2018
  ident: pone.0246631.ref061
– volume: 66
  start-page: 1223
  issue: 11
  year: 2013
  ident: pone.0246631.ref007
  article-title: Investigating complexity in systematic reviews of interventions by using a spectrum of methods
  publication-title: J. Clin. Epidemiol
  doi: 10.1016/j.jclinepi.2013.06.014
– volume: 21
  start-page: 397
  issue: 4
  year: 2011
  ident: pone.0246631.ref002
  article-title: When are complex interventions ‘complex’? When are simple interventions ‘simple’?
  publication-title: Eur. J. Public Health
  doi: 10.1093/eurpub/ckr084
– volume: 66
  start-page: 1215
  issue: 11
  year: 2013
  ident: pone.0246631.ref009
  article-title: Systematic reviews of complex interventions: framing the review question
  publication-title: J. Clin. Epidemiol
  doi: 10.1016/j.jclinepi.2013.05.013
– volume: 10
  start-page: 325
  year: 2000
  ident: pone.0246631.ref057
  article-title: WinBUGS—a Bayesian modelling framework: concepts, structure, and extensibility
  publication-title: Stat. Comput.
  doi: 10.1023/A:1008929526011
– volume: 62
  start-page: 808
  issue: 3
  year: 2020
  ident: pone.0246631.ref033
  article-title: Network meta-analysis of multicomponent interventions
  publication-title: Biom. J
  doi: 10.1002/bimj.201800167
– volume: 4
  start-page: e000882
  issue: Suppl 1
  year: 2019
  ident: pone.0246631.ref022
  article-title: Qualitative evidence synthesis for complex interventions and guideline development: clarification of the purpose, designs and relevant methods
  publication-title: BMJ Glob. Health
  doi: 10.1136/bmjgh-2018-000882
– volume: 90
  start-page: 11
  year: 2017
  ident: pone.0246631.ref012
  article-title: AHRQ series on complex intervention systematic reviews-paper 2: defining complexity, formulating scope, and questions
  publication-title: J. Clin. Epidemiol
  doi: 10.1016/j.jclinepi.2017.06.012
– volume: 90
  start-page: 43
  year: 2017
  ident: pone.0246631.ref017
  article-title: AHRQ series on complex intervention systematic reviews—paper 6: PRISMA-CI extension statement and checklist
  publication-title: J. Clin. Epidemiol
  doi: 10.1016/j.jclinepi.2017.06.016
– volume: 66
  start-page: 1251
  issue: 11
  year: 2013
  ident: pone.0246631.ref011
  article-title: Assessing the applicability of findings in systematic reviews of complex interventions can enhance the utility of reviews for decision making
  publication-title: J. Clin. Epidemiol
  doi: 10.1016/j.jclinepi.2013.06.017
– volume: 4
  start-page: 75
  year: 2012
  ident: pone.0246631.ref034
  article-title: Stability of additive treatment effects in multiple treatment comparison meta-analysis: a simulation study
  publication-title: Clin. Epidemiol
– volume: 39
  start-page: 135
  year: 2018
  ident: pone.0246631.ref037
  article-title: Meta-Analysis of Complex Interventions
  publication-title: Annu. Rev. Public Health
  doi: 10.1146/annurev-publhealth-040617-014112
– volume: 90
  start-page: 28
  year: 2017
  ident: pone.0246631.ref016
  article-title: AHRQ series on complex intervention systematic reviews-paper 4: selecting analytic approaches
  publication-title: J. Clin. Epidemiol
  doi: 10.1016/j.jclinepi.2017.06.014
– volume: 340
  start-page: c221
  year: 2010
  ident: pone.0246631.ref044
  article-title: Meta-analysis of individual participant data: rationale, conduct, and reporting
  publication-title: BMJ
  doi: 10.1136/bmj.c221
– volume: 4
  start-page: e000848
  issue: Suppl 1
  year: 2019
  ident: pone.0246631.ref024
  article-title: Considerations of complexity in rating certainty of evidence in systematic reviews: a primer on using the GRADE approach in global health
  publication-title: BMJ Glob. Health
  doi: 10.1136/bmjgh-2018-000848
– volume: 19
  start-page: 16
  issue: 1
  year: 2016
  ident: pone.0246631.ref036
  article-title: Approaches for synthesising complex mental health interventions in meta-analysis
  publication-title: Evid. Based Ment. Health
  doi: 10.1136/eb-2015-102275
– volume: 7
  start-page: 40
  issue: 3
  year: 2007
  ident: pone.0246631.ref041
  article-title: meta: An R package for meta-analysis
  publication-title: R News
– volume: 48
  start-page: 1945
  issue: 12
  year: 2018
  ident: pone.0246631.ref054
  article-title: Dismantling cognitive-behaviour therapy for panic disorder: a systematic review and component network meta-analysis
  publication-title: Psychol. Med
  doi: 10.1017/S0033291717003919
– volume: 32
  start-page: 2747
  issue: 16
  year: 2013
  ident: pone.0246631.ref043
  article-title: Meta-analysis of randomised trials with a continuous outcome according to baseline imbalance and availability of individual participant data
  publication-title: Stat. Med.
  doi: 10.1002/sim.5726
– ident: pone.0246631.ref059
– volume: 4
  start-page: e000858
  issue: Suppl 1
  year: 2019
  ident: pone.0246631.ref023
  article-title: Synthesising quantitative evidence in systematic reviews of complex health interventions
  publication-title: BMJ Glob. Health
  doi: 10.1136/bmjgh-2018-000858
– volume: 66
  start-page: 1244
  issue: 11
  year: 2013
  ident: pone.0246631.ref013
  article-title: Identifying, documenting, and examining heterogeneity in systematic reviews of complex interventions
  publication-title: J. Clin. Epidemiol
  doi: 10.1016/j.jclinepi.2013.06.013
– volume: 337
  start-page: a1655
  year: 2008
  ident: pone.0246631.ref004
  article-title: Developing and evaluating complex interventions: the new Medical Research Council guidance
  publication-title: BMJ
  doi: 10.1136/bmj.a1655
– volume: 169
  start-page: 1158
  issue: 9
  year: 2009
  ident: pone.0246631.ref027
  article-title: Mixed Intervention Comparison Meta-Analysis of Complex Interventions: Psychological Interventions in Coronary Heart Disease
  publication-title: Am. J. Epidemiol
  doi: 10.1093/aje/kwp014
– volume: 48
  start-page: 55
  issue: 1
  year: 2016
  ident: pone.0246631.ref050
  article-title: Characteristics of effective self-management interventions in patients with COPD: individual patient data meta-analysis
  publication-title: Eur. Respir. J
  doi: 10.1183/13993003.01860-2015
– volume: 6
  start-page: 12
  issue: 1
  year: 2006
  ident: pone.0246631.ref058
  article-title: Making BUGS Open
  publication-title: R News
– volume: 66
  start-page: 1209
  issue: 11
  year: 2013
  ident: pone.0246631.ref001
  article-title: Complex interventions and their implications for systematic reviews: a pragmatic approach
  publication-title: J. Clin. Epidemiol
  doi: 10.1016/j.jclinepi.2013.06.004
– year: 2020
  ident: pone.0246631.ref060
  article-title: netmeta: Network Meta-Analysis using Frequentist Methods
  publication-title: R package version 1.2–1
– volume: 9
  start-page: e86754
  issue: 1
  year: 2014
  ident: pone.0246631.ref053
  article-title: Characteristics of Networks of Interventions: A Description of a Database of 186 Published Networks
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0086754
– year: 2020
  ident: pone.0246631.ref038
  article-title: Component network meta-analysis compared to a matching method in a disconnected network: A case study
  publication-title: Biom. J
– volume: 21
  start-page: 1559
  issue: 11
  year: 2002
  ident: pone.0246631.ref040
  article-title: How should meta-regression analyses be undertaken and interpreted?.
  publication-title: Stat. Med
  doi: 10.1002/sim.1187
– volume: 66
  start-page: 1244
  issue: 11
  year: 2013
  ident: pone.0246631.ref010
  article-title: Identifying, documenting, and examining heterogeneity in systematic reviews of complex interventions
  publication-title: J. Clin. Epidemiol
  doi: 10.1016/j.jclinepi.2013.06.013
– volume: 82
  start-page: 20
  year: 2017
  ident: pone.0246631.ref028
  article-title: Bibliographic study showed improving statistical methodology of network meta-analyses published between 1999 and 2015
  publication-title: J. Clin. Epidemiol
  doi: 10.1016/j.jclinepi.2016.11.002
– volume: 90
  start-page: 19
  year: 2017
  ident: pone.0246631.ref015
  article-title: AHRQ series on complex intervention systematic reviews-paper 3: adapting frameworks to develop protocols
  publication-title: J. Clin. Epidemiol
  doi: 10.1016/j.jclinepi.2017.06.013
– volume: 318
  start-page: 1687
  issue: 17
  year: 2017
  ident: pone.0246631.ref052
  article-title: Comparisons of Interventions for Preventing Falls in Older Adults: A Systematic Review and Meta-analysis
  publication-title: JAMA
  doi: 10.1001/jama.2017.15006
– volume: 11
  start-page: 2063
  year: 2016
  ident: pone.0246631.ref049
  article-title: Do self-management interventions in COPD patients work and which patients benefit most? An individual patient data meta-analysis
  publication-title: Int. J. Chron. Obstruct. Pulmon. Dis
  doi: 10.2147/COPD.S107884
– start-page: CD004364
  issue: 1
  year: 2007
  ident: pone.0246631.ref039
  article-title: Combined psychotherapy plus antidepressants for panic disorder with or without agoraphobia
  publication-title: Cochrane Database Syst. Rev
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SubjectTerms Antidepressants
Anxiety
Behavior modification
Behavior therapy
Biology and Life Sciences
Biometrics
Care and treatment
Cognitive ability
Computer and Information Sciences
Computer programs
Confidence intervals
Drafting software
Editing
Education
Epidemiology
Evaluation
Exercise
Graduate schools
Graduate studies
Health care
Health care facilities
Health promotion
Intervention
Management
Medical protocols
Medicine
Medicine and Health Sciences
Meta-analysis
Methods
Panic attacks
Panic disorders
Physical Sciences
Preventive medicine
Primary care
Psychiatry
Psychotherapy
Public health
Regression analysis
Rehabilitation
Research and Analysis Methods
Secondary data analysis
Social Sciences
Software
Statistical analysis
Statistics
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Teaching methods
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Title A review of methods for addressing components of interventions in meta-analysis
URI https://www.ncbi.nlm.nih.gov/pubmed/33556155
https://www.proquest.com/docview/2487424924
https://www.proquest.com/docview/2487747699
https://pubmed.ncbi.nlm.nih.gov/PMC7870082
https://doaj.org/article/bf3de81f6df04147ace7c03da8c2ca2e
http://dx.doi.org/10.1371/journal.pone.0246631
Volume 16
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