The pulmonary mycobiome—A study of subjects with and without chronic obstructive pulmonary disease

• Published in: PloS one Vol. 16; no. 4; p. e0248967
• Main Authors: Martinsen, Einar M. H., Eagan, Tomas M. L., Leiten, Elise O., Haaland, Ingvild, Husebø, Gunnar R., Knudsen, Kristel S., Drengenes, Christine, Sanseverino, Walter, Paytuví-Gallart, Andreu, Nielsen, Rune
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 07.04.2021; Public Library of Science (PLoS)
• Subjects: Aged; Airway management; Alveoli; Antibiotics; Biology and Life Sciences; Biotechnology; Bronchoscopy; Bronchus; Case-Control Studies; Catheters; Chronic obstructive pulmonary disease; Computer and Information Sciences; Computer programs; Data collection; Diagnosis; Disease; DNA, Fungal - isolation & purification; Drafting software; Editing; Female; Funding; Fungi; Fungi - classification; Fungi - drug effects; Fungi - isolation & purification; Genetic aspects; Hospitals; Humans; Indoor environments; Lung - microbiology; Lung diseases; Lung diseases, Obstructive; Male; Medical instruments; Medicine; Medicine and Health Sciences; Methodology; Middle Aged; Mouth - microbiology; Mycobiome - drug effects; Norway - epidemiology; Obstructive lung disease; Outpatient care facilities; Participation; Physical Sciences; Physiological aspects; Pulmonary Disease, Chronic Obstructive - drug therapy; Pulmonary Disease, Chronic Obstructive - epidemiology; Pulmonary Disease, Chronic Obstructive - microbiology; Research and Analysis Methods; Reviews; Software; Spirometry; Taxonomy; Thorax; Norway; United States > US; Spain

The fungal part of the pulmonary microbiome (mycobiome) is understudied. We report the composition of the oral and pulmonary mycobiome in participants with COPD compared to controls in a large-scale single-centre bronchoscopy study (MicroCOPD). Oral wash and bronchoalveolar lavage (BAL) was collecte...