Genomic landscape of pathogenic mutation of APC, KRAS, TP53, PIK3CA, and MLH1 in Indonesian colorectal cancer

• Published in: PloS one Vol. 17; no. 6; p. e0267090
• Main Authors: Marbun, Vania Myralda Giamour, Erlina, Linda, Lalisang, Toar Jean Maurice
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 16.06.2022; Public Library of Science (PLoS)
• Subjects: Adenomatous polyposis coli; Bioinformatics; Biology and Life Sciences; Cancer; Care and treatment; Chemotherapy; Chromosomes; Colorectal cancer; Colorectal carcinoma; Deoxyribonucleic acid; DNA; Ethics; Family medical history; Frameshift mutation; Gene mutations; Gene sequencing; Genetic aspects; K-Ras protein; Life expectancy; Medical records; Medicine and Health Sciences; MLH1 protein; Mutation; Next-generation sequencing; Oncology, Experimental; p53 Protein; Patient outcomes; Patients; Population studies; Precision medicine; Rectum; Surgery; Survival; Indonesia

Colorectal cancer (CRC) needs several mutations to occur in various genes, and can vary widely in different individuals; hence it is essential to be discovered in a specific population. Until recently, there has been no known study describing APC, TP53, PIK3CA, KRAS, and MLH1 of CRC in Indonesian po...