Scalp bacterial shift in Alopecia areata

• Published in: PloS one Vol. 14; no. 4; p. e0215206
• Main Authors: Pinto, Daniela, Sorbellini, Elisabetta, Marzani, Barbara, Rucco, Mariangela, Giuliani, Giammaria, Rinaldi, Fabio
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 11.04.2019; Public Library of Science (PLoS)
• Subjects: Abundance; Acne; Adult; Alopecia; Alopecia Areata - complications; Alopecia Areata - microbiology; Arthritis; Bacteria; Baldness; Biology and Life Sciences; Biopsy; Care and treatment; Case-Control Studies; Criminal investigation; Deoxyribonucleic acid; DNA; DNA, Bacterial - genetics; DNA, Bacterial - isolation & purification; Dysbacteriosis; Dysbiosis - complications; Dysbiosis - microbiology; Epidermis; Female; Hair; Hair loss; Humans; Hypodermis; Hypoxia; Inflammation; Male; Medicine and Health Sciences; Microbiota; Microbiota - genetics; Microorganisms; Middle Aged; Population studies; Propionibacterium - isolation & purification; Relative abundance; Research and analysis methods; Scalp; Scalp - microbiology; Skin; Staphylococcus aureus - isolation & purification; Staphylococcus aureus infections; Staphylococcus epidermidis - isolation & purification; Young Adult; Italy
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0215206

The role of microbial dysbiosis in scalp disease has been recently hypothesized. However, little information is available with regards to the association between microbial population on the scalp and hair diseases related to hair growth. Here we investigated bacterial communities in healthy and Alopecia areata (AA) subjects. The analysis of bacterial distribution at the genus level highlighted an increase of Propionibacterium in AA subjects alongside a general decrease of Staphylococcus. Analysis of log Relative abundance of main bacterial species inhabiting the scalp showed a significant increase of Propionibacterium acnes in AA subjects compared to control ones. AA scalp condition is also associated with a significant decrease of Staphylococcus epidermidis relative abundance. No significant changes were found for Staphylococcus aureus. Therefore, data from sequencing profiling of the bacterial population strongly support a different microbial composition of the different area surrounded hair follicle from the epidermis to hypodermis, highlighting differences between normal and AA affected the scalp. Our results highlight, for the first time, the presence of a microbial shift on the scalp of patients suffering from AA and gives the basis for a larger and more complete study of microbial population involvement in hair disorders.