In vitro and in vivo performance of epinastine hydrochloride-releasing contact lenses

• Published in: PloS one Vol. 14; no. 1; p. e0210362
• Main Authors: Minami, Takahiro, Ishida, Waka, Kishimoto, Tatsuma, Nakajima, Isana, Hino, Shiori, Arai, Ritsuko, Matsunaga, Toru, Fukushima, Atsuki, Yamagami, Satoru
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 30.01.2019; Public Library of Science (PLoS)
• Subjects: Allergies; Animals; Biology and Life Sciences; Care and treatment; Conjunctivitis; Conjunctivitis, Allergic - chemically induced; Conjunctivitis, Allergic - drug therapy; Contact lenses; Contact Lenses, Hydrophilic; Delayed-Action Preparations - administration & dosage; Delayed-Action Preparations - pharmacokinetics; Dibenzazepines - administration & dosage; Dibenzazepines - pharmacokinetics; Disease Models, Animal; Dosage and administration; Drug delivery; Drug Delivery Systems; Engineering and Technology; Epinastine; Functional groups; Glaucoma; Guinea Pigs; Hay fever; Histamine - toxicity; Histamine H1 Antagonists - administration & dosage; Histamine H1 Antagonists - pharmacokinetics; Hydrogels; Imidazoles - administration & dosage; Imidazoles - pharmacokinetics; In Vitro Techniques; In vivo methods and tests; Male; Medical schools; Medicine and Health Sciences; Methods; Ophthalmic agents; Ophthalmic Solutions; Osmolar Concentration; Patient compliance; Patient outcomes; Phosphates; Physical Sciences; Polymerization; Quality of life; Releasing; Research and Analysis Methods; Soft contact lenses; Surface active agents; Japan

A number of drug-releasing contact lenses are currently being studied to address issues inherent in eye drops as a drug delivery method. In this study, we developed epinastine hydrochloride-releasing daily soft contact lenses for treatment of allergic conjunctivitis and examined their in vitro and i...