Correlation between genetic and environmental risk factors for age-related macular degeneration in Brazilian patients

• Published in: PloS one Vol. 17; no. 6; p. e0268795
• Main Authors: Rim, Priscila H H, de Vasconcellos, José Paulo C, de Melo, Mônica B, Medina, Flavio M C, Sacconi, Daniela P D, Lana, Tamires P, Hirata, Fabio E, Magna, Luis A, Marques-de-Faria, Antonia P
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 03.06.2022; Public Library of Science (PLoS)
• Subjects: Age; Age factors in disease; Age related diseases; Alleles; Analysis; Angiogenesis Inhibitors; Atrophy; Biology and Life Sciences; Body mass index; Brazil - epidemiology; Cardiovascular Diseases; Care and treatment; Cataracts; Cholesterol; Complement Factor H - genetics; Correlation; Cross-Sectional Studies; Data collection; Demographics; Diagnosis; Discriminant analysis; Disease control; Ecology and Environmental Sciences; Environmental risk; Eye diseases; Family medical history; Genes; Genetic analysis; Genetic diversity; Genetic susceptibility; Genetic variance; Genetics; Genotype; Health risk assessment; Health risks; Heart diseases; High-Temperature Requirement A Serine Peptidase 1 - genetics; Humans; Hypertension; Lifestyles; Macular degeneration; Medical imaging; Medicine and Health Sciences; People and places; Phenotypes; Physical activity; Polymorphism, Single Nucleotide; Population; Population studies; Questionnaires; Regression analysis; Risk analysis; Risk assessment; Risk Factors; Serine Endopeptidases - genetics; Smoking; Testing; Variables; Vascular Endothelial Growth Factor A - genetics; Visual Acuity; Wet Macular Degeneration; Brazil

To analyze the correlations between age-related macular degeneration (AMD) and genetic and environmental risk factors for in a Brazilian population. Cross-sectional study with a control group. We collected data on 236 participants 50 years of age or older (141 with AMD and 95 controls without the di...