Therapeutic Role of Ursolic Acid on Ameliorating Hepatic Steatosis and Improving Metabolic Disorders in High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease Rats

• Published in: PloS one Vol. 9; no. 1; p. e86724
• Main Authors: Li, Songtao, Meng, Fanyu, Liao, Xilu, Wang, Yemei, Sun, Zongxiang, Guo, Fuchuan, Li, Xiaoxia, Meng, Man, Li, Ying, Sun, Changhao
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 29.01.2014; Public Library of Science (PLoS)
• Subjects: Acid resistance; Acids; Animals; Biology; CD36 Antigens - genetics; CD36 Antigens - metabolism; Diabetes mellitus; Diacylglycerol O-Acyltransferase - genetics; Diacylglycerol O-Acyltransferase - metabolism; Diet; Diet, High-Fat; Dietary Fats - adverse effects; Disorders; Enzymes; Fatty liver; Fatty Liver - drug therapy; Fatty Liver - etiology; Fatty Liver - metabolism; Fatty Liver - pathology; Gene Expression; Health aspects; High fat diet; Insulin; Insulin Resistance; Laboratory animals; Lipase - genetics; Lipase - metabolism; Lipid metabolism; Lipid Metabolism - drug effects; Lipids; Liver; Liver - drug effects; Liver - metabolism; Liver - pathology; Liver diseases; Male; Medicine; Metabolic disorders; Metabolism; mRNA; Non-alcoholic Fatty Liver Disease; Obesity; Obesity - drug therapy; Obesity - etiology; Obesity - metabolism; Obesity - pathology; Oxidation resistance; Oxidative stress; Peroxisome proliferator-activated receptors; Plants (botany); PPAR alpha - antagonists & inhibitors; PPAR alpha - genetics; PPAR alpha - metabolism; Rats; Rats, Sprague-Dawley; RNA; RNA, Messenger - genetics; RNA, Messenger - metabolism; RNA, Small Interfering - genetics; RNA, Small Interfering - metabolism; Rodents; Steatosis; Triterpenes - pharmacology; Ursolic Acid

Non-alcoholic fatty liver disease (NAFLD) is one of the most prevalent liver diseases around the world, and is closely associated with obesity, diabetes, and insulin resistance. Ursolic acid (UA), an ubiquitous triterpenoid with multifold biological roles, is distributed in various plants. This stud...