Polymorphisms of SP110 Are Associated with both Pulmonary and Extra-Pulmonary Tuberculosis among the Vietnamese

• Published in: PloS one Vol. 9; no. 7; p. e99496
• Main Authors: Fox, Gregory J., Sy, Dinh Ngoc, Nhung, Nguyen Viet, Yu, Bing, Ellis, Magda K., Van Hung, Nguyen, Cuong, Nguyen Kim, Thi Lien, Luu, Marks, Guy B., Saunders, Bernadette M., Britton, Warwick J.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 09.07.2014; Public Library of Science (PLoS)
• Subjects: Adult; Analysis; Apoptosis; Asian Continental Ancestry Group - genetics; Biological response modifiers; Biology and Life Sciences; Case-Control Studies; Epidemiology; Ethics; Female; Genetic aspects; Genetic Association Studies - methods; Genetic diversity; Genetic variance; Health aspects; Hospitals; Humans; Immune response; Immune system; Immunity; Infections; Infectious diseases; Interferon; Lung diseases; Macrophages; Macrophages - metabolism; Male; Medical research; Medical schools; Medicine and Health Sciences; Middle Aged; Minor Histocompatibility Antigens; Morbidity; Mortality; Nuclear Proteins - genetics; Polymorphism; Polymorphism, Single Nucleotide; Population; Proteins; Public health; Risk factors; Signaling; Single nucleotide polymorphisms; Single-nucleotide polymorphism; Systematic review; Tuberculosis; Tuberculosis - genetics; Tuberculosis - immunology; Tuberculosis - pathology; Vietnam; Young Adult; Sydney New South Wales Australia; Australia; Vietnam
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0099496

Tuberculosis (TB) is an infectious disease that remains a major cause of morbidity and mortality worldwide, yet the reasons why only 10% of people infected with Mycobacterium tuberculosis go on to develop clinical disease are poorly understood. Genetically determined variation in the host immune res...