Analysis of Complete Nucleotide Sequences of Angolan Hepatitis B Virus Isolates Reveals the Existence of a Separate Lineage within Genotype E

• Published in: PloS one Vol. 9; no. 3; p. e92223
• Main Authors: Lago, Barbara V., Mello, Francisco C., Ribas, Flavia S., Valente, Fatima, Soares, Caroline C., Niel, Christian, Gomes, Selma A.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 14.03.2014; Public Library of Science (PLoS)
• Subjects: Adult; Aged; Amino acids; Antigenic determinants; Antigens; Antigens, Surface - genetics; Base Sequence; Bayesian analysis; Biology and life sciences; Cell surface; Cladistic analysis; Conditional probability; Deoxyribonucleic acid; DNA; DNA-Directed DNA Polymerase - genetics; Epitopes; Genetic aspects; Genetic Variation; Genomes; Genotype; Genotype & phenotype; Genotypes; HBX protein; Hepatitis; Hepatitis B; Hepatitis B surface antigen; Hepatitis B virus; Hepatitis B virus - classification; Hepatitis B virus - genetics; Hepatitis B virus - isolation & purification; Humans; Infections; Laboratories; Lymphocytes T; Male; Medicine and health sciences; Middle Aged; Molecular Sequence Data; Mutation; Nucleotides - genetics; Phylogenetics; Phylogeny; Proteins; Virology; Viruses; Young Adult

Hepatitis B virus genotype E (HBV/E) is highly prevalent in Western Africa. In this work, 30 HBV/E isolates from HBsAg positive Angolans (staff and visitors of a private hospital in Luanda) were genetically characterized: 16 of them were completely sequenced and the pre-S/S sequences of the remainin...