The effect of suppressive thyroxine therapy in nodular goiter in postmenopausal women and 2 year’s bone mineral density change
The efficacy of thyroxine suppressive therapy in reducing nodular growth and its effect to bone mineral density (BMD) in postmenopausal women is still debated. This study aimed to evaluate the therapeutic effect of thyroxine and its influence on BMD. Postmenopausal women with nodular or multinodular...
Saved in:
| Published in | ENDOCRINE JOURNAL Vol. 65; no. 11; pp. 1101 - 1109 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English Japanese |
| Published |
Japan
The Japan Endocrine Society
01.01.2018
Japan Science and Technology Agency |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | The efficacy of thyroxine suppressive therapy in reducing nodular growth and its effect to bone mineral density (BMD) in postmenopausal women is still debated. This study aimed to evaluate the therapeutic effect of thyroxine and its influence on BMD. Postmenopausal women with nodular or multinodular goiter during 2013–2015 at Chang Gung Memorial Hospital were enrolled and retrospectively traced back to the first date of visit or treatment. Ninety-four eligible patients were enrolled, of whom 45 were thyroxine-treated (LT-4 group) and 49 were treatment-naïve (control group). Data, including volume of nodules, were analyzed retrospectively. BMD was measured in each LT-4 group patient since the year of enrollment. Nodular volumes were reduced in both LT-4 (from 4.89 ± 4.46 to 4.10 ± 4.57 mL, p = 0.033) and control group (3.48 ± 4.36 to 3.09 ± 2.88 mL, p = 0.239) at initial 2-year follow-up. Nodular volume in LT-4 group increased insignificantly (from 4.89 ± 4.46 to 4.91 ± 5.40 mL, p = 0.711) at the end of 7-year follow-up. The best cut-off predictive nodular volume that may have responded to thyroxine is 2.6 mL (AUC, 0.740; sensitivity, 0.750; specificity, 0.733) during first 2 year. Lumbar spine, total hip and femoral neck BMD were not significantly changed during 2 year’s thyroxine suppression therapy. In conclusion, thyroxine suppressive therapy in postmenopausal women had significant reduction in nodule volume at initial 2 years of treatment, especially in volume larger than 2.6 mL. Prolonged thyroxine treatment did not benefit nodular size reduction and may affect BMD minimally in postmenopausal women. |
|---|---|
| AbstractList | The efficacy of thyroxine suppressive therapy in reducing nodular growth and its effect to bone mineral density (BMD) in postmenopausal women is still debated. This study aimed to evaluate the therapeutic effect of thyroxine and its influence on BMD. Postmenopausal women with nodular or multinodular goiter during 2013-2015 at Chang Gung Memorial Hospital were enrolled and retrospectively traced back to the first date of visit or treatment. Ninety-four eligible patients were enrolled, of whom 45 were thyroxine-treated (LT-4 group) and 49 were treatment-naïve (control group). Data, including volume of nodules, were analyzed retrospectively. BMD was measured in each LT-4 group patient since the year of enrollment. Nodular volumes were reduced in both LT-4 (from 4.89 ± 4.46 to 4.10 ± 4.57 mL, p = 0.033) and control group (3.48 ± 4.36 to 3.09 ± 2.88 mL, p = 0.239) at initial 2-year follow-up. Nodular volume in LT-4 group increased insignificantly (from 4.89 ± 4.46 to 4.91 ± 5.40 mL, p = 0.711) at the end of 7-year follow-up. The best cut-off predictive nodular volume that may have responded to thyroxine is 2.6 mL (AUC, 0.740; sensitivity, 0.750; specificity, 0.733) during first 2 year. Lumbar spine, total hip and femoral neck BMD were not significantly changed during 2 year's thyroxine suppression therapy. In conclusion, thyroxine suppressive therapy in postmenopausal women had significant reduction in nodule volume at initial 2 years of treatment, especially in volume larger than 2.6 mL. Prolonged thyroxine treatment did not benefit nodular size reduction and may affect BMD minimally in postmenopausal women. Abstract. The efficacy of thyroxine suppressive therapy in reducing nodular growth and its effect to bone mineral density (BMD) in postmenopausal women is still debated. This study aimed to evaluate the therapeutic effect of thyroxine and its influence on BMD. Postmenopausal women with nodular or multinodular goiter during 2013 - 2015 at Chang Gung Memorial Hospital were enrolled and retrospectively traced back to the first date of visit or treatment. Ninety-four eligible patients were enrolled, of whom 45 were thyroxine-treated (LT-4 group) and 49 were treatment-naive (control group). Data, including volume of nodules, were analyzed retrospectively. BMD was measured in each LT-4 group patient since the year of enrollment. Nodular volumes were reduced in both LT-4 (from 4.89 +- 4.46 to 4.10 +- 4.57 mL, p = 0.033) and control group (3.48 +- 4.36 to 3.09 +- 2.88 mL, p = 0.239) at initial 2-year follow-up. Nodular volume in LT-4 group increased insignificantly (from 4.89 +- 4.46 to 4.91 +- 5.40 mL, p = 0.711) at the end of 7-year follow-up. The best cut-off predictive nodular volume that may have responded to thyroxine is 2.6 mL (AUC, 0.740; sensitivity, 0.750; specificity, 0.733) during first 2 year. Lumbar spine, total hip and femoral neck BMD were not significantly changed during 2 year's thyroxine suppression therapy. In conclusion, thyroxine suppressive therapy in postmenopausal women had significant reduction in nodule volume at initial 2 years of treatment, especially in volume larger than 2.6 mL. Prolonged thyroxine treatment did not benefit nodular size reduction and may affect BMD minimally in postmenopausal women. |
| Author | Chen, Szu-Tah Chen, Chiung-Ya Hwang, Jawl-Shan Lin, Jen-Der Liu, Feng-Hsuan Huang, Bie-Yu |
| Author_xml | – sequence: 1 fullname: Chen, Chiung-Ya organization: Division of Endocrinology and Metabolism, Department of Internal Medicine, Chang Gung Memorial Hospital, Chang Gung University, Kweishan, Taoyuan, Taiwan – sequence: 2 fullname: Chen, Szu-Tah organization: Division of Endocrinology and Metabolism, Department of Internal Medicine, Chang Gung Memorial Hospital, Chang Gung University, Kweishan, Taoyuan, Taiwan – sequence: 3 fullname: Huang, Bie-Yu organization: Division of Endocrinology and Metabolism, Department of Internal Medicine, Chang Gung Memorial Hospital, Chang Gung University, Kweishan, Taoyuan, Taiwan – sequence: 4 fullname: Hwang, Jawl-Shan organization: Division of Endocrinology and Metabolism, Department of Internal Medicine, Chang Gung Memorial Hospital, Chang Gung University, Kweishan, Taoyuan, Taiwan – sequence: 5 fullname: Lin, Jen-Der organization: Division of Endocrinology and Metabolism, Department of Internal Medicine, Chang Gung Memorial Hospital, Chang Gung University, Kweishan, Taoyuan, Taiwan – sequence: 6 fullname: Liu, Feng-Hsuan organization: Division of Endocrinology and Metabolism, Department of Internal Medicine, Chang Gung Memorial Hospital, Chang Gung University, Kweishan, Taoyuan, Taiwan |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30158361$$D View this record in MEDLINE/PubMed |
| BookMark | eNpdkc1u1DAUhS1URKeFB2CDLLFhk-Kf2HGWqCotqBKbsrYc52Ymo8RO7QTIrq_B6_Ek2MwwSGx8_XPu52OfC3TmvAOEXlNyRQWp3oNrvQ37q5vPVBWEMvEMbSgvVVGKkpyhDanTvqpFfY4uYtwTwrko-Qt0zgkViku6QU8PO8DQdWBn7Dscl2kKEGP_DfC8W4P_0bs8g2CmFfcOO98ugwl46_sZQt6ZfJxHcH4ySzQD_u7TAhvXYoZXMOHX08-Im-QbjwkVkqIFF_t5xXZn3BZeouedGSK8OtZL9PXjzcP1XXH_5fbT9Yf7wsqazYWxLReq4S2jXLYlY7IxtCqJMqxWleBQkwZIV1nZyK4Ew3l6reBd21GoSFfzS_TuwJ2Cf1wgznrso4VhMA78EjUjdSVUJQVN0rf_Sfd-CS6504xxIktGywykB5UNPsYAnZ5CP5qwakp0jkcf49E5Hp3jST1vjuSlGaE9dfzNIwluD4J02lszeDekX_t3v32Uf6jJbmaSZJemIjSlhOah5lQpIlUi3R1I-zibLZyuMmHu7QAnczL35vHk8iRJAYWk478BlEfBQg |
| CitedBy_id | crossref_primary_10_11106_ijt_2022_15_1_36 crossref_primary_10_26416_ObsGin_72_1_2024_9563 crossref_primary_10_7759_cureus_26353 crossref_primary_10_2174_1381612825666190618125726 |
| Cites_doi | 10.1007/s00198-004-1702-6 10.1161/CIRCULATIONAHA.112.096024 10.7326/0003-4819-138-4-200302180-00010 10.1210/jc.2001-011762 10.1210/jc.83.11.3881 10.4158/EP.9.3.194 10.1007/BF03350907 10.1007/BF00353745 10.7326/0003-4819-122-1-199501010-00001 10.2174/1871530311313010003 10.1016/S1043-2760(03)00144-9 10.1056/NEJM198707093170202 10.1089/thy.1995.5.81 10.1016/8756-3282(95)00258-4 10.1159/000347144 10.1507/endocrj.K10E-144 10.1210/jc.2002-020365 10.1016/0002-9343(90)90178-G 10.1016/j.jfma.2015.06.014 10.1007/s40618-014-0128-z 10.1002/jbmr.5650100202 10.1046/j.1365-2265.1997.1280950.x 10.1089/thy.1997.7.691 10.1056/NEJM199411103311901 10.1001/archinternmed.2012.402 10.1016/j.abb.2010.06.021 10.1055/s-2002-34992 10.1359/jbmr.1998.13.5.763 10.1159/000089489 10.7326/0003-4819-128-5-199803010-00008 10.1007/s001980050281 10.1007/BF03349813 10.1001/jama.2015.5161 10.1155/2014/515297 10.1001/jama.2015.0956 10.1002/1097-0142(1950)3:1<32::AID-CNCR2820030106>3.0.CO;2-3 10.1016/S0140-6736(71)91383-3 10.1210/jc.2007-1876 10.14336/AD.2016.0325 10.1309/AJCPPHLWMI3JV4LA 10.1001/jama.291.2.228 10.1046/j.1365-2265.1997.3221125.x |
| ContentType | Journal Article |
| Copyright | The Japan Endocrine Society Copyright Japan Science and Technology Agency 2018 |
| Copyright_xml | – notice: The Japan Endocrine Society – notice: Copyright Japan Science and Technology Agency 2018 |
| CorporateAuthor | Chang Gung University Division of Endocrinology and Metabolism Department of Internal Medicine Chang Gung Memorial Hospital |
| CorporateAuthor_xml | – name: Chang Gung University – name: Department of Internal Medicine – name: Division of Endocrinology and Metabolism – name: Chang Gung Memorial Hospital |
| DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION 7QP 7T5 7TK 8FD FR3 H94 P64 RC3 7X8 |
| DOI | 10.1507/endocrj.EJ18-0125 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef Calcium & Calcified Tissue Abstracts Immunology Abstracts Neurosciences Abstracts Technology Research Database Engineering Research Database AIDS and Cancer Research Abstracts Biotechnology and BioEngineering Abstracts Genetics Abstracts MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef Genetics Abstracts Technology Research Database AIDS and Cancer Research Abstracts Immunology Abstracts Engineering Research Database Calcium & Calcified Tissue Abstracts Neurosciences Abstracts Biotechnology and BioEngineering Abstracts MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic Genetics Abstracts |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1348-4540 |
| EndPage | 1109 |
| ExternalDocumentID | 10_1507_endocrj_EJ18_0125 30158361 cq6endoc_2018_006511_005_1101_11093188068 article_endocrj_65_11_65_EJ18_0125_article_char_en |
| Genre | Journal Article |
| GroupedDBID | --- .55 .GJ 29G 2WC 3O- 53G 5GY 5RE AAEJM AAUGY ACPRK ACRZS ADBBV AENEX AJJEV ALMA_UNASSIGNED_HOLDINGS BAWUL BKOMP CS3 DIK DU5 E3Z EBD EBS EJD EMOBN F5P JMI JSF JSH KQ8 MOJWN M~E OK1 P2P RJT RNS RZJ SV3 TKC TR2 X7M XSB ZGI ZXP CGR CUY CVF ECM EIF GROUPED_DOAJ NPM AAYXX CITATION 7QP 7T5 7TK 8FD FR3 H94 P64 RC3 7X8 |
| ID | FETCH-LOGICAL-c692t-acd358b3d2136d4226ba17408a298753e90be0f7c6b6f4ea3300353fdf1e70f93 |
| ISSN | 0918-8959 |
| IngestDate | Fri Jun 28 03:10:40 EDT 2024 Thu Oct 10 20:45:09 EDT 2024 Fri Aug 23 00:42:52 EDT 2024 Sat Sep 28 08:37:34 EDT 2024 Fri May 31 15:04:10 EDT 2024 Thu Aug 17 20:30:00 EDT 2023 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 11 |
| Keywords | Multinodular goiter Bone mineral density Thyroxine |
| Language | English Japanese |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c692t-acd358b3d2136d4226ba17408a298753e90be0f7c6b6f4ea3300353fdf1e70f93 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| OpenAccessLink | https://www.jstage.jst.go.jp/article/endocrj/65/11/65_EJ18-0125/_article/-char/en |
| PMID | 30158361 |
| PQID | 2230642149 |
| PQPubID | 2048504 |
| PageCount | 9 |
| ParticipantIDs | proquest_miscellaneous_2097587651 proquest_journals_2230642149 crossref_primary_10_1507_endocrj_EJ18_0125 pubmed_primary_30158361 medicalonline_journals_cq6endoc_2018_006511_005_1101_11093188068 jstage_primary_article_endocrj_65_11_65_EJ18_0125_article_char_en |
| PublicationCentury | 2000 |
| PublicationDate | 2018-01-01 |
| PublicationDateYYYYMMDD | 2018-01-01 |
| PublicationDate_xml | – month: 01 year: 2018 text: 2018-01-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | Japan |
| PublicationPlace_xml | – name: Japan – name: Kyoto |
| PublicationTitle | ENDOCRINE JOURNAL |
| PublicationTitleAlternate | Endocr J |
| PublicationYear | 2018 |
| Publisher | The Japan Endocrine Society Japan Science and Technology Agency |
| Publisher_xml | – name: The Japan Endocrine Society – name: Japan Science and Technology Agency |
| References | 35 Wemeau JL, Caron P, Schvartz C, Schlienger JL, Orgiazzi J, et al. (2002) Effects of thyroid-stimulating hormone suppression with levothyroxine in reducing the volume of solitary thyroid nodules and improving extranodular nonpalpable changes: a randomized, double-blind, placebo-controlled trial by the French Thyroid Research Group. J Clin Endocrinol Metab 87: 4928–4934. 13 Blum MR, Bauer DC, Collet TH, Fink HA, Cappola AR, et al. (2015) Subclinical thyroid dysfunction and fracture risk: a meta-analysis. JAMA 313: 2055–2065. 22 Chen SC, Lo TC, Chang JH, Kuo HW (2014) Variations in aging, gender, menopause, and obesity and their effects on hypertension in Taiwan. Int J Hypertens 2014: 515297. 5 Gharib H, James EM, Charboneau JW, Naessens JM, Offord KP, et al. (1987) Suppressive therapy with levothyroxine for solitary thyroid nodules. N Engl J Med 317: 70–75. 39 Johnell O, Kanis J (2005) Epidemiology of osteoporotic fractures. Osteoporos Int 16 Suppl 2: S3–S7. 40 Fraser SA, Smith DA, Anderson JB, Wilson GM (1971) Osteoporosis and fractures following thyrotoxicosis. Lancet 297: 981–983. 1 Morganti S, Ceda G, Saccani M, Milli B, Ugolotti D, et al. (2005) Thyroid disease in the elderly: sex-related differences in clinical expression. J Endocrinol Invest 28: 101–104. 8 Costante G, Crocetti U, Schifino E, Ludovico O, Capula C, et al. (2004) Slow growth of benign thyroid nodules after menopause: no need for long-term thyroxine suppressive therapy in post-menopausal women. J Endocrinol Invest 27: 31–36. 28 Quadbeck B, Pruellage J, Roggenbuck U, Hirche H, Janssen OE, et al. (2002) Long-term follow-up of thyroid nodule growth. Exp Clin Endocrinol Diabetes 110: 348–354. 2 La Rosa GL, Lupo L, Giuffrida D, Gullo D, Vigneri R, et al. (1995) Levothyroxine and potassium iodide are both effective in treating benign solitary solid cold nodules of the thyroid. Ann Intern Med 122: 1–8. 31 Durante C, Costante G, Lucisano G, Bruno R, Meringolo D, et al. (2015) The natural history of benign thyroid nodules. JAMA 313: 926–935. 23 Cibas ES, Ali SZ (2009) The Bethesda system for reporting thyroid cytopathology. Am J Clin Pathol 132: 658–665. 38 Melton LJ 3rd (1995) Perspectives: how many women have osteoporosis now? J Bone Miner Res 10: 175–177. 14 Lee SJ, Kim KM, Lee EY, Song MK, Kang DR, et al. (2016) Low normal TSH levels are associated with impaired BMD and hip geometry in the elderly. Aging Dis 7: 734–743. 44 De Rosa G, Testa A, Giacomini D, Carrozza C, Astazi P, et al. (1997) Prospective study of bone loss in pre- and post-menopausal women on L-thyroxine therapy for non-toxic goitre. Clin Endocrinol (Oxf) 47: 529–535. 30 Berghout A, Wiersinga WM, Smits NJ, Touber JL (1990) Interrelationships between age, thyroid volume, thyroid nodularity, and thyroid function in patients with sporadic nontoxic goiter. Am J Med 89: 602–608. 10 Sawin CT, Geller A, Wolf PA, Belanger AJ, Baker E, et al. (1994) Low serum thyrotropin concentrations as a risk factor for atrial fibrillation in older persons. N Engl J Med 331: 1249–1252. 19 Appetecchia M (2005) Effects on bone mineral density by treatment of benign nodular goiter with mildly suppressive doses of L-thyroxine in a cohort women study. Horm Res 64: 293–298. 9 Cesareo R, Iozzino M, Isgrò MA, Annunziata F, Di Stasio E (2010) Short term effects of levothyroxine treatment in thyroid multinodular disease. Endocr J 57: 803–809. 15 Bassett JD, Williams GR (2003) The molecular actions of thyroid hormone in bone. Trends Endocrinol Metab 14: 356–364. 27 Youden WJ (1950) Index for rating diagnostic tests. Cancer 3: 32–35. 24 Andrioli M, Carzaniga C, Persani L (2013) Standardized ultrasound report for thyroid nodules: the endocrinologist’s viewpoint. Eur Thyroid J 2: 37–48. 16 Gogakos AI, Bassett JD, Williams GR (2010) Thyroid and bone. Arch Biochem Biophys 503: 129–136. 18 Müller CG, Bayley TA, Harrison JE, Tsang R (1995) Possible limited bone loss with suppressive thyroxine therapy is unlikely to have clinical relevance. Thyroid 5: 81–87. 33 Chen K, Lin CC, Wu HY, Sun C, Chen C, et al. (1964) Pilot project on endemic goiter prevention with iodized salt in Hsinchu County, Taiwan, China. Memoirs Coll Med Nat Taiwan Univ 10: 73–92 (In Chinese). 26 Kanis J, Glüer CC (2000) An update on the diagnosis and assessment of osteoporosis with densitometry. Osteoporos Int 11: 192–202. 34 Castro MR, Caraballo PJ, Morris JC (2002) Effectiveness of thyroid hormone suppressive therapy in benign solitary thyroid nodules: a meta-analysis. J Clin Endocrinol Metab 87: 4154–4159. 46 Collet T-H, Gussekloo J, Bauer DC, den Elzen WP, Cappola AR, et al. (2012) Subclinical hyperthyroidism and the risk of coronary heart disease and mortality. Arch Intern Med 172: 799–809. 17 Surks MI, Ortiz E, Daniels GH, Sawin CT, Col NF, et al. (2004) Subclinical thyroid disease: scientific review and guidelines for diagnosis and management. JAMA 291: 228–238. 32 Kuma K, Matsuzuka F, Yokozawa T, Miyauchi A, Sugawara M (1994) Fate of untreated benign thyroid nodules: results of long-term follow-up. World J Surg 18: 495–498. 47 Donangelo I, Suh SY (2017) Subclinical hyperthyroidism: when to consider treatment. Am Fam Physician 95: 710–716. 43 Finkelstein JS, Brockwell SE, Mehta V, Greendale GA, Sowers MR, et al. (2008) Bone mineral density changes during the menopause transition in a multiethnic cohort of women. J Clin Endocrinol Metab 93: 861–868. 7 Gharib H, Mazzaferri EL (1998) Thyroxine suppressive therapy in patients with nodular thyroid disease. Ann Intern Med 128: 386–394. 11 Uzzan B, Campos J, Cucherat M, Nony P, Boissel JP, et al. (1996) Effects on bone mass of long term treatment with thyroid hormones: a meta-analysis. J Clin Endocrinol Metab 81: 4278–4289. 3 Lima N, Knobel M, Cavaliere H, Sztejnsznajd C, Tomimori E, et al. (1997) Levothyroxine suppressive therapy is partially effective in treating patients with benign, solid thyroid nodules and multinodular goiters. Thyroid 7: 691–697. 21 Chow S, Huang C, Lee Y (1997) Demographic characteristics and medical aspects of menopausal women in Taiwan. J Formos Med Assoc 96: 806–811. 29 Alexander EK, Hurwitz S, Heering JP, Benson CB, Frates MC, et al. (2003) Natural history of benign solid and cystic thyroid nodules. Ann Intern Med 138: 315–318. 37 Tang KT, Wang FF, Pan WH, Lin JD, Won GS, et al. (2016) Iodine status of adults in Taiwan 2005–2008, 5 years after the cessation of mandatory salt iodization. J Formos Med Assoc 115: 645–651. 25 Gallo M, Pesenti M, Valcavi R (2003) Ultrasound thyroid nodule measurements: the “gold standard” and its limitations in clinical decision making. Endocr Pract 9: 194–199. 45 Gencer B, Collet T-H, Virgini V, Bauer DC, Gussekloo J, et al. (2012) Subclinical thyroid dysfunction and the risk of heart failure events: an individual participant data analysis from six prospective cohorts. Circulation 126: 1040–1049. 12 Gencer B, Collet TH, Virgini V, Auer R, Rodondi N (2013) Subclinical thyroid dysfunction and cardiovascular outcomes among prospective cohort studies. Endocr Metab Immune Disord Drug Targets 13: 4–12. 20 Riggs BL, Melton LJ 3rd (1995) The worldwide problem of osteoporosis: insights afforded by epidemiology. Bone 17: S505–S511. 6 Mainini E, Martinelli I, Morandi G, Villa S, Stefani I, et al. (1995) Levothyroxine suppressive therapy for solitary thyroid nodule. J Endocrinol Invest 18: 796–799. 41 Riggs BL, Khosla S, Melton LJ 3rd (1998) A unitary model for involutional osteoporosis: estrogen deficiency causes both type I and type II osteoporosis in postmenopausal women and contributes to bone loss in aging men. J Bone Miner Res 13: 763–773. 42 Guo CY, Weetman AP, Eastell R (1997) Longitudinal changes of bone mineral density and bone turnover in postmenopausal women on thyroxine. Clin Endocrinol (Oxf) 46: 301–307. 36 Puzziello A, Carrano M, Angrisani E, Marotta V, Faggiano A, et al. (2014) Evolution of benign thyroid nodules under levothyroxine non-suppressive therapy. J Endocrinol Invest 37: 1181–1186. 4 Zelmanovitz Fv, Genro S, Gross JL (1998) Suppressive therapy with levothyroxine for solitary thyroid nodules: a double-blind controlled clinical study and cumulative meta-analyses. J Clin Endocrinol Metab 83: 3881–3885. 22 44 23 45 24 46 25 47 26 27 28 29 30 31 10 32 11 33 12 34 13 35 14 36 15 37 16 38 17 39 18 19 1 2 3 4 5 6 7 8 9 40 41 20 42 21 43 |
| References_xml | – ident: 39 doi: 10.1007/s00198-004-1702-6 – ident: 45 doi: 10.1161/CIRCULATIONAHA.112.096024 – ident: 29 doi: 10.7326/0003-4819-138-4-200302180-00010 – ident: 34 doi: 10.1210/jc.2001-011762 – ident: 4 doi: 10.1210/jc.83.11.3881 – ident: 25 doi: 10.4158/EP.9.3.194 – ident: 8 doi: 10.1007/BF03350907 – ident: 32 doi: 10.1007/BF00353745 – ident: 33 – ident: 2 doi: 10.7326/0003-4819-122-1-199501010-00001 – ident: 12 doi: 10.2174/1871530311313010003 – ident: 15 doi: 10.1016/S1043-2760(03)00144-9 – ident: 5 doi: 10.1056/NEJM198707093170202 – ident: 18 doi: 10.1089/thy.1995.5.81 – ident: 20 doi: 10.1016/8756-3282(95)00258-4 – ident: 24 doi: 10.1159/000347144 – ident: 9 doi: 10.1507/endocrj.K10E-144 – ident: 35 doi: 10.1210/jc.2002-020365 – ident: 30 doi: 10.1016/0002-9343(90)90178-G – ident: 37 doi: 10.1016/j.jfma.2015.06.014 – ident: 36 doi: 10.1007/s40618-014-0128-z – ident: 38 doi: 10.1002/jbmr.5650100202 – ident: 42 doi: 10.1046/j.1365-2265.1997.1280950.x – ident: 47 – ident: 3 doi: 10.1089/thy.1997.7.691 – ident: 10 doi: 10.1056/NEJM199411103311901 – ident: 46 doi: 10.1001/archinternmed.2012.402 – ident: 16 doi: 10.1016/j.abb.2010.06.021 – ident: 28 doi: 10.1055/s-2002-34992 – ident: 41 doi: 10.1359/jbmr.1998.13.5.763 – ident: 19 doi: 10.1159/000089489 – ident: 7 doi: 10.7326/0003-4819-128-5-199803010-00008 – ident: 1 – ident: 11 – ident: 26 doi: 10.1007/s001980050281 – ident: 6 doi: 10.1007/BF03349813 – ident: 13 doi: 10.1001/jama.2015.5161 – ident: 22 doi: 10.1155/2014/515297 – ident: 31 doi: 10.1001/jama.2015.0956 – ident: 27 doi: 10.1002/1097-0142(1950)3:1<32::AID-CNCR2820030106>3.0.CO;2-3 – ident: 40 doi: 10.1016/S0140-6736(71)91383-3 – ident: 43 doi: 10.1210/jc.2007-1876 – ident: 14 doi: 10.14336/AD.2016.0325 – ident: 21 – ident: 23 doi: 10.1309/AJCPPHLWMI3JV4LA – ident: 17 doi: 10.1001/jama.291.2.228 – ident: 44 doi: 10.1046/j.1365-2265.1997.3221125.x |
| SSID | ssj0033543 ssib022572652 ssib002822051 ssib000750009 |
| Score | 2.2246604 |
| Snippet | The efficacy of thyroxine suppressive therapy in reducing nodular growth and its effect to bone mineral density (BMD) in postmenopausal women is still debated.... Abstract. The efficacy of thyroxine suppressive therapy in reducing nodular growth and its effect to bone mineral density (BMD) in postmenopausal women is... |
| SourceID | proquest crossref pubmed medicalonline jstage |
| SourceType | Aggregation Database Index Database Publisher |
| StartPage | 1101 |
| SubjectTerms | Absorptiometry, Photon Aged Bone density Bone Density - drug effects Bone mineral density Female Femur Femur Neck - diagnostic imaging Femur Neck - drug effects Goiter Goiter, Nodular - drug therapy Health risk assessment Hip Humans Lumbar Vertebrae - diagnostic imaging Lumbar Vertebrae - drug effects Middle Aged Multinodular goiter Nodules Patients Post-menopause Postmenopause Retrospective Studies Spine (lumbar) Thyroxine Thyroxine - pharmacology Thyroxine - therapeutic use Treatment Outcome |
| Title | The effect of suppressive thyroxine therapy in nodular goiter in postmenopausal women and 2 year’s bone mineral density change |
| URI | https://www.jstage.jst.go.jp/article/endocrj/65/11/65_EJ18-0125/_article/-char/en http://mol.medicalonline.jp/en/journal/download?GoodsID=cq6endoc/2018/006511/005&name=1101-1109e https://www.ncbi.nlm.nih.gov/pubmed/30158361 https://www.proquest.com/docview/2230642149 https://search.proquest.com/docview/2097587651 |
| Volume | 65 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| ispartofPNX | Endocrine Journal, 2018, Vol.65(11), pp.1101-1109 |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3dbtMwFLbKQAgJIf4pDGQkrqiyJXGTxncU1Gkq2xBaK21XUew40IklY2kY29Veg5fgoXgSzrGdpB0DATdRlThOnO-zzzk-PyXkReYPkkD0fUdwKRyQeMoBE8x1EjcFcRpKxXXdgu2dcHPaH-8Fe53O94WopWou1uTZpXkl_4MqnANcMUv2H5BtOoUT8BvwhSMgDMe_xtgEZKDOV1ZHJqr1iwJ18vS4-IoapEmw0tl9eZHqoNMPBeYd6_jxosQoczCcqxKw0uUYtDvB753CFKgjIXjZEwX0dTjTNap7KUa9g_Yu69SEdnM_TwuJCYW9xQHo8AFl3fszWF6c_eTihd2zypm0m9OvZ8rZr7RgrBIrXZF9J3Z_e5ycfHJ2P1pu220LL7qwbTEGVaBdv3BgrSuhN9Rpp4t7lXB_xG3pcGVWaoY7oYGp9VQv5eZvJ2rKegsLM2g53qUSI9BBIkp_nYO10Vi_qcnFXq7OvfMu3phubcWT0d7kCrnqD3iAIaRv3zdeK8YCE6VZv671osMj1n95wJIedO0ATAGs8XDz0LjnTJmU31s9WvuZ3Ca3rNlCh4aDd0hH5XfJ9W0bmHGPnAMVqaEiLTK6QEXaUJFaKtJZTi0VqaEinlmmItVUpIAY9SlS8cf5t5IiCaklIbUkpIaE98l0YzR5s-nYP_dwZMj9uZPIlAWRYKnvsTDFfG6RgHXsRonP0YZW3BXKzQYyFGHWVwlj6PRmWZp5auBmnD0gKzk89RGhqQyUDP0klJ7se55IuFJ-lAq0jplKeZe8rD91fGRquMRo-wIuscUlRlxixKVLhgaMpqmd3k3TMACzGY_NPU0TzJSEdl3yagnH2E65MpafQ91NjFMiRv0fugJBGCM_8cAZFkgMoy5ZraFv7_ZtYnofhvS8uQzyAJ18Sa6KCtq4fBCAihN4XfLQUKYZCQjzIGKh9_jPnT8hN9oZu0pW5seVegqq91w803z_CeRd320 |
| link.rule.ids | 315,786,790,27955,27956 |
| linkProvider | Colorado Alliance of Research Libraries |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+effect+of+suppressive+thyroxine+therapy+in+nodular+goiter+in+postmenopausal+women+and+2+year%E2%80%99s+bone+mineral+density+change&rft.jtitle=Endocrine+journal&rft.au=Chen%2C+Chiung-Ya&rft.au=Chen%2C+Szu-Tah&rft.au=Bie-Yu%2C+Huang&rft.au=Hwang%2C+Jawl-Shan&rft.date=2018-01-01&rft.pub=Japan+Science+and+Technology+Agency&rft.issn=0918-8959&rft.eissn=1348-4540&rft.volume=65&rft.issue=11&rft.spage=1101&rft_id=info:doi/10.1507%2Fendocrj.EJ18-0125&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0918-8959&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0918-8959&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0918-8959&client=summon |