Total and differential WBC counts are related with coronary artery atherosclerosis and increase the risk for cardiovascular disease in Koreans

Inflammation is a key mechanism of atherosclerosis. White blood cells (WBCs) play a pivotal role in the inflammatory process. We investigated the relationships between total and differential WBC counts and multi-detector cardiac computed tomography (MDCT) findings, as well as the risk of cardiovascu...

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Published inPloS one Vol. 12; no. 7; p. e0180332
Main Authors Kim, Jung Hee, Lim, Soo, Park, Kyong Soo, Jang, Hak Chul, Choi, Sung Hee
Format Journal Article
LanguageEnglish
Published United States Public Library of Science 28.07.2017
Public Library of Science (PLoS)
Subjects
Aged
Arteriosclerosis
Asian Continental Ancestry Group
Atherosclerosis
Atherosclerosis - blood
Atherosclerosis - epidemiology
Biology and Life Sciences
Blood cells
Blood pressure
Calcification
Cardiovascular disease
Cardiovascular diseases
Cardiovascular Diseases - blood
Cardiovascular Diseases - epidemiology
Care and treatment
CAT scans
Cholesterol
Computed tomography
Coronary artery
Coronary artery disease
Coronary Artery Disease - blood
Coronary Artery Disease - epidemiology
Coronary heart disease
Coronary vessels
Cross-Sectional Studies
Diabetes
Female
Health aspects
Health risks
Heart
Heart diseases
Humans
Inflammation
Internal medicine
Kaplan-Meier Estimate
Koreans
Leukocytes
Leukocytes - cytology
Logistic Models
Lymphocytes
Male
Medical imaging
Medical records
Medicine
Medicine and Health Sciences
Middle Aged
Monocytes
Morphology
Patients
Plaques
Regression analysis
Regression models
Retrospective Studies
Risk
Risk Factors
Stenosis
Studies
Systematic review
Tomography
White blood cell count
Women
Japan
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Abstract Inflammation is a key mechanism of atherosclerosis. White blood cells (WBCs) play a pivotal role in the inflammatory process. We investigated the relationships between total and differential WBC counts and multi-detector cardiac computed tomography (MDCT) findings, as well as the risk of cardiovascular disease in asymptomatic patients in Korea. We recruited asymptomatic men (n = 7274) and women (n = 5478) aged ≥30 years who were free of known coronary heart disease. All patients underwent MDCT during a routine health check-up in the Seoul National University Bundang Hospital between 2006 and 2007, and were followed-up for 5.6 years. We reviewed medical records for cardiovascular diseases (CVDs) and covariates. In covariate-adjusted logistic regression models for MDCT findings, subjects within the third tertile of all WBC subtypes had a higher risk for significant stenosis and noncalcified plaques compared with the first tertile of each subtype. In Cox proportional hazard regression models for the risk of CVDs, subjects within the third tertiles of lymphocytes and monocytes were at an increased risk of CVDs (total WBC, HR = 1.22 [1.02-1.44]; lymphocyte, HR = 1.47 [1.25-1.74]; monocytes, HR = 1.26 [1.02-1.35]) even after further adjustment for covariates and coronary artery stenosis. Total WBC counts were related with the severity of coronary artery disease, and higher WBC counts increased the risk of CVDs in asymptomatic Koreans mainly by virtue of monocytes.
AbstractList Objective Inflammation is a key mechanism of atherosclerosis. White blood cells (WBCs) play a pivotal role in the inflammatory process. We investigated the relationships between total and differential WBC counts and multi-detector cardiac computed tomography (MDCT) findings, as well as the risk of cardiovascular disease in asymptomatic patients in Korea. Materials and methods We recruited asymptomatic men (n = 7274) and women (n = 5478) aged [greater than or equal to]30 years who were free of known coronary heart disease. All patients underwent MDCT during a routine health check-up in the Seoul National University Bundang Hospital between 2006 and 2007, and were followed-up for 5.6 years. We reviewed medical records for cardiovascular diseases (CVDs) and covariates. Results In covariate-adjusted logistic regression models for MDCT findings, subjects within the third tertile of all WBC subtypes had a higher risk for significant stenosis and noncalcified plaques compared with the first tertile of each subtype. In Cox proportional hazard regression models for the risk of CVDs, subjects within the third tertiles of lymphocytes and monocytes were at an increased risk of CVDs (total WBC, HR = 1.22 [1.02-1.44]; lymphocyte, HR = 1.47 [1.25-1.74]; monocytes, HR = 1.26 [1.02-1.35]) even after further adjustment for covariates and coronary artery stenosis. Conclusions Total WBC counts were related with the severity of coronary artery disease, and higher WBC counts increased the risk of CVDs in asymptomatic Koreans mainly by virtue of monocytes.
Inflammation is a key mechanism of atherosclerosis. White blood cells (WBCs) play a pivotal role in the inflammatory process. We investigated the relationships between total and differential WBC counts and multi-detector cardiac computed tomography (MDCT) findings, as well as the risk of cardiovascular disease in asymptomatic patients in Korea. We recruited asymptomatic men (n = 7274) and women (n = 5478) aged [greater than or equal to]30 years who were free of known coronary heart disease. All patients underwent MDCT during a routine health check-up in the Seoul National University Bundang Hospital between 2006 and 2007, and were followed-up for 5.6 years. We reviewed medical records for cardiovascular diseases (CVDs) and covariates. In covariate-adjusted logistic regression models for MDCT findings, subjects within the third tertile of all WBC subtypes had a higher risk for significant stenosis and noncalcified plaques compared with the first tertile of each subtype. In Cox proportional hazard regression models for the risk of CVDs, subjects within the third tertiles of lymphocytes and monocytes were at an increased risk of CVDs (total WBC, HR = 1.22 [1.02-1.44]; lymphocyte, HR = 1.47 [1.25-1.74]; monocytes, HR = 1.26 [1.02-1.35]) even after further adjustment for covariates and coronary artery stenosis. Total WBC counts were related with the severity of coronary artery disease, and higher WBC counts increased the risk of CVDs in asymptomatic Koreans mainly by virtue of monocytes.
Inflammation is a key mechanism of atherosclerosis. White blood cells (WBCs) play a pivotal role in the inflammatory process. We investigated the relationships between total and differential WBC counts and multi-detector cardiac computed tomography (MDCT) findings, as well as the risk of cardiovascular disease in asymptomatic patients in Korea.We recruited asymptomatic men (n = 7274) and women (n = 5478) aged ≥30 years who were free of known coronary heart disease. All patients underwent MDCT during a routine health check-up in the Seoul National University Bundang Hospital between 2006 and 2007, and were followed-up for 5.6 years. We reviewed medical records for cardiovascular diseases (CVDs) and covariates.In covariate-adjusted logistic regression models for MDCT findings, subjects within the third tertile of all WBC subtypes had a higher risk for significant stenosis and noncalcified plaques compared with the first tertile of each subtype. In Cox proportional hazard regression models for the risk of CVDs, subjects within the third tertiles of lymphocytes and monocytes were at an increased risk of CVDs (total WBC, HR = 1.22 [1.02-1.44]; lymphocyte, HR = 1.47 [1.25-1.74]; monocytes, HR = 1.26 [1.02-1.35]) even after further adjustment for covariates and coronary artery stenosis.Total WBC counts were related with the severity of coronary artery disease, and higher WBC counts increased the risk of CVDs in asymptomatic Koreans mainly by virtue of monocytes.
Inflammation is a key mechanism of atherosclerosis. White blood cells (WBCs) play a pivotal role in the inflammatory process. We investigated the relationships between total and differential WBC counts and multi-detector cardiac computed tomography (MDCT) findings, as well as the risk of cardiovascular disease in asymptomatic patients in Korea.OBJECTIVEInflammation is a key mechanism of atherosclerosis. White blood cells (WBCs) play a pivotal role in the inflammatory process. We investigated the relationships between total and differential WBC counts and multi-detector cardiac computed tomography (MDCT) findings, as well as the risk of cardiovascular disease in asymptomatic patients in Korea.We recruited asymptomatic men (n = 7274) and women (n = 5478) aged ≥30 years who were free of known coronary heart disease. All patients underwent MDCT during a routine health check-up in the Seoul National University Bundang Hospital between 2006 and 2007, and were followed-up for 5.6 years. We reviewed medical records for cardiovascular diseases (CVDs) and covariates.MATERIALS AND METHODSWe recruited asymptomatic men (n = 7274) and women (n = 5478) aged ≥30 years who were free of known coronary heart disease. All patients underwent MDCT during a routine health check-up in the Seoul National University Bundang Hospital between 2006 and 2007, and were followed-up for 5.6 years. We reviewed medical records for cardiovascular diseases (CVDs) and covariates.In covariate-adjusted logistic regression models for MDCT findings, subjects within the third tertile of all WBC subtypes had a higher risk for significant stenosis and noncalcified plaques compared with the first tertile of each subtype. In Cox proportional hazard regression models for the risk of CVDs, subjects within the third tertiles of lymphocytes and monocytes were at an increased risk of CVDs (total WBC, HR = 1.22 [1.02-1.44]; lymphocyte, HR = 1.47 [1.25-1.74]; monocytes, HR = 1.26 [1.02-1.35]) even after further adjustment for covariates and coronary artery stenosis.RESULTSIn covariate-adjusted logistic regression models for MDCT findings, subjects within the third tertile of all WBC subtypes had a higher risk for significant stenosis and noncalcified plaques compared with the first tertile of each subtype. In Cox proportional hazard regression models for the risk of CVDs, subjects within the third tertiles of lymphocytes and monocytes were at an increased risk of CVDs (total WBC, HR = 1.22 [1.02-1.44]; lymphocyte, HR = 1.47 [1.25-1.74]; monocytes, HR = 1.26 [1.02-1.35]) even after further adjustment for covariates and coronary artery stenosis.Total WBC counts were related with the severity of coronary artery disease, and higher WBC counts increased the risk of CVDs in asymptomatic Koreans mainly by virtue of monocytes.CONCLUSIONSTotal WBC counts were related with the severity of coronary artery disease, and higher WBC counts increased the risk of CVDs in asymptomatic Koreans mainly by virtue of monocytes.
Objective Inflammation is a key mechanism of atherosclerosis. White blood cells (WBCs) play a pivotal role in the inflammatory process. We investigated the relationships between total and differential WBC counts and multi-detector cardiac computed tomography (MDCT) findings, as well as the risk of cardiovascular disease in asymptomatic patients in Korea. Materials and methods We recruited asymptomatic men (n = 7274) and women (n = 5478) aged ≥30 years who were free of known coronary heart disease. All patients underwent MDCT during a routine health check-up in the Seoul National University Bundang Hospital between 2006 and 2007, and were followed-up for 5.6 years. We reviewed medical records for cardiovascular diseases (CVDs) and covariates. Results In covariate-adjusted logistic regression models for MDCT findings, subjects within the third tertile of all WBC subtypes had a higher risk for significant stenosis and noncalcified plaques compared with the first tertile of each subtype. In Cox proportional hazard regression models for the risk of CVDs, subjects within the third tertiles of lymphocytes and monocytes were at an increased risk of CVDs (total WBC, HR = 1.22 [1.02–1.44]; lymphocyte, HR = 1.47 [1.25–1.74]; monocytes, HR = 1.26 [1.02–1.35]) even after further adjustment for covariates and coronary artery stenosis. Conclusions Total WBC counts were related with the severity of coronary artery disease, and higher WBC counts increased the risk of CVDs in asymptomatic Koreans mainly by virtue of monocytes.
Objective Inflammation is a key mechanism of atherosclerosis. White blood cells (WBCs) play a pivotal role in the inflammatory process. We investigated the relationships between total and differential WBC counts and multi-detector cardiac computed tomography (MDCT) findings, as well as the risk of cardiovascular disease in asymptomatic patients in Korea. Materials and methods We recruited asymptomatic men (n = 7274) and women (n = 5478) aged ≥30 years who were free of known coronary heart disease. All patients underwent MDCT during a routine health check-up in the Seoul National University Bundang Hospital between 2006 and 2007, and were followed-up for 5.6 years. We reviewed medical records for cardiovascular diseases (CVDs) and covariates. Results In covariate-adjusted logistic regression models for MDCT findings, subjects within the third tertile of all WBC subtypes had a higher risk for significant stenosis and noncalcified plaques compared with the first tertile of each subtype. In Cox proportional hazard regression models for the risk of CVDs, subjects within the third tertiles of lymphocytes and monocytes were at an increased risk of CVDs (total WBC, HR = 1.22 [1.02–1.44]; lymphocyte, HR = 1.47 [1.25–1.74]; monocytes, HR = 1.26 [1.02–1.35]) even after further adjustment for covariates and coronary artery stenosis. Conclusions Total WBC counts were related with the severity of coronary artery disease, and higher WBC counts increased the risk of CVDs in asymptomatic Koreans mainly by virtue of monocytes.
Inflammation is a key mechanism of atherosclerosis. White blood cells (WBCs) play a pivotal role in the inflammatory process. We investigated the relationships between total and differential WBC counts and multi-detector cardiac computed tomography (MDCT) findings, as well as the risk of cardiovascular disease in asymptomatic patients in Korea. We recruited asymptomatic men (n = 7274) and women (n = 5478) aged ≥30 years who were free of known coronary heart disease. All patients underwent MDCT during a routine health check-up in the Seoul National University Bundang Hospital between 2006 and 2007, and were followed-up for 5.6 years. We reviewed medical records for cardiovascular diseases (CVDs) and covariates. In covariate-adjusted logistic regression models for MDCT findings, subjects within the third tertile of all WBC subtypes had a higher risk for significant stenosis and noncalcified plaques compared with the first tertile of each subtype. In Cox proportional hazard regression models for the risk of CVDs, subjects within the third tertiles of lymphocytes and monocytes were at an increased risk of CVDs (total WBC, HR = 1.22 [1.02-1.44]; lymphocyte, HR = 1.47 [1.25-1.74]; monocytes, HR = 1.26 [1.02-1.35]) even after further adjustment for covariates and coronary artery stenosis. Total WBC counts were related with the severity of coronary artery disease, and higher WBC counts increased the risk of CVDs in asymptomatic Koreans mainly by virtue of monocytes.
Audience Academic
Author Park, Kyong Soo
Kim, Jung Hee
Choi, Sung Hee
Lim, Soo
Jang, Hak Chul
AuthorAffiliation 1 Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
2 Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea
Beijing Key Laboratory of Diabetes Prevention and Research, CHINA
AuthorAffiliation_xml – name: 1 Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea
– name: Beijing Key Laboratory of Diabetes Prevention and Research, CHINA
– name: 2 Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea
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  surname: Kim
  fullname: Kim, Jung Hee
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  surname: Lim
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  givenname: Kyong Soo
  surname: Park
  fullname: Park, Kyong Soo
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  givenname: Hak Chul
  surname: Jang
  fullname: Jang, Hak Chul
– sequence: 5
  givenname: Sung Hee
  orcidid: 0000-0003-0740-8116
  surname: Choi
  fullname: Choi, Sung Hee
BackLink https://www.ncbi.nlm.nih.gov/pubmed/28753607$$D View this record in MEDLINE/PubMed
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15780773 - Ann Epidemiol. 2005 Apr;15(4):266-71
12490960 - Nature. 2002 Dec 19-26;420(6917):868-74
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SSID ssj0053866
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Snippet Inflammation is a key mechanism of atherosclerosis. White blood cells (WBCs) play a pivotal role in the inflammatory process. We investigated the relationships...
Objective Inflammation is a key mechanism of atherosclerosis. White blood cells (WBCs) play a pivotal role in the inflammatory process. We investigated the...
Objective Inflammation is a key mechanism of atherosclerosis. White blood cells (WBCs) play a pivotal role in the inflammatory process. We investigated the...
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pubmedcentral
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StartPage e0180332
SubjectTerms Aged
Arteriosclerosis
Asian Continental Ancestry Group
Atherosclerosis
Atherosclerosis - blood
Atherosclerosis - epidemiology
Biology and Life Sciences
Blood cells
Blood pressure
Calcification
Cardiovascular disease
Cardiovascular diseases
Cardiovascular Diseases - blood
Cardiovascular Diseases - epidemiology
Care and treatment
CAT scans
Cholesterol
Computed tomography
Coronary artery
Coronary artery disease
Coronary Artery Disease - blood
Coronary Artery Disease - epidemiology
Coronary heart disease
Coronary vessels
Cross-Sectional Studies
Diabetes
Female
Health aspects
Health risks
Heart
Heart diseases
Humans
Inflammation
Internal medicine
Kaplan-Meier Estimate
Koreans
Leukocytes
Leukocytes - cytology
Logistic Models
Lymphocytes
Male
Medical imaging
Medical records
Medicine
Medicine and Health Sciences
Middle Aged
Monocytes
Morphology
Patients
Plaques
Regression analysis
Regression models
Retrospective Studies
Risk
Risk Factors
Stenosis
Studies
Systematic review
Tomography
White blood cell count
Women
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Title Total and differential WBC counts are related with coronary artery atherosclerosis and increase the risk for cardiovascular disease in Koreans
URI https://www.ncbi.nlm.nih.gov/pubmed/28753607
https://www.proquest.com/docview/1991550535
https://www.proquest.com/docview/1924600582
https://pubmed.ncbi.nlm.nih.gov/PMC5533311
https://doaj.org/article/24a235d104894cfea43a3f9b33676a18
http://dx.doi.org/10.1371/journal.pone.0180332
Volume 12
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