Enhanced responsiveness to selective serotonin reuptake inhibitors during lactation

• Published in: PloS one Vol. 10; no. 2; p. e0117339
• Main Authors: Jury, Nicholas J, McCormick, Betsy A, Horseman, Nelson D, Benoit, Stephen C, Gregerson, Karen A
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 17.02.2015; Public Library of Science (PLoS)
• Subjects: Animals; Antidepressants; Behavior; Behavior, Animal - drug effects; Body temperature; Brain; Brain research; Breast Feeding; Citalopram; Citalopram - pharmacology; Citalopram - therapeutic use; Depression, Postpartum - drug therapy; Dorsal raphe nucleus; Dorsal Raphe Nucleus - metabolism; Dorsal Raphe Nucleus - pathology; Emotional behavior; Female; Females; House mouse; Immunohistochemistry; Lactation; Lactation - drug effects; Male; Medicine; Mental depression; Mice; Mice, Inbred C57BL; Mood; Motor Activity - drug effects; Neurosciences; Optical density; Phenols (Class of compounds); Physiological aspects; Physiology; Postpartum; Postpartum depression; Pregnancy; Pregnant women; Radioimmunoassay; Raphe nuclei; Serotonin; Serotonin - blood; Serotonin - metabolism; Serotonin uptake inhibitors; Serotonin Uptake Inhibitors - pharmacology; Serotonin Uptake Inhibitors - therapeutic use; Stress, Physiological - drug effects; Womens health; United States > US; Ohio

The physiology of mood regulation in the postpartum is poorly understood despite the fact that postpartum depression (PPD) is a common pathology. Serotonergic mechanisms and their dysfunction are widely presumed to be involved, which has led us to investigate whether lactation induces changes in cen...