Circulating High-Molecular-Weight (HMW) Adiponectin Level Is Related with Breast Cancer Risk Better than Total Adiponectin: A Case-Control Study

• Published in: PloS one Vol. 10; no. 6; p. e0129246
• Main Authors: Guo, Ming-ming, Duan, Xue-ning, Cui, Shu-de, Tian, Fu-guo, Cao, Xu-chen, Geng, Cui-zhi, Fan, Zhi-min, Wang, Xiang, Wang, Shu, Jiang, Hong-chuan, Zhang, Jian-guo, Jin, Feng, Tang, Jin-hai, Liang, Hong, Yang, Zhen-lin, Wang, Hai-bo, Wang, Qi-tang, Li, Guo-lou, Li, Liang, Zhu, Shi-guang, Zuo, Wen-shu, Liu, Li-yuan, Wang, Lu, Ma, Dan-dan, Liu, Shu-chen, Xiang, Yu-juan, Liu, Lu, Ye, Chun-miao, Zhou, Wen-zhong, Wang, Fei, Yu, Li-xiang, Ma, Zhong-bing, Yu, Zhi-gang
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 12.06.2015; Public Library of Science (PLoS)
• Subjects: Adiponectin; Adiponectin - blood; Adiponectin - chemistry; Adult; Aged; Body mass; Breast cancer; Breast Neoplasms - blood; Breast Neoplasms - diagnosis; Breast Neoplasms - etiology; Cancer; Cancer research; Case studies; Case-Control Studies; China; Diabetes; Epidemiology; Female; Genetics; Health risk assessment; Health risks; Hospitals; Humans; Kinases; Medical diagnosis; Medicine; Menarche; Menopause; Metabolism; Middle Aged; Molecular chains; Molecular Weight; Obesity; Post-menopause; Postmenopausal women; Prognosis; Public health; Risk; Risk factors; Subgroups; Surgery; Thyroid gland; Weight control; Womens health; China; Beijing China

The level of total adiponectin, a mixture of different adiponectin forms, has been reported associated with breast cancer risk with inconsistent results. Whether the different forms play different roles in breast cancer risk prediction is unclear. To examine this, we measured total and high molecula...