Circulating High-Molecular-Weight (HMW) Adiponectin Level Is Related with Breast Cancer Risk Better than Total Adiponectin: A Case-Control Study
The level of total adiponectin, a mixture of different adiponectin forms, has been reported associated with breast cancer risk with inconsistent results. Whether the different forms play different roles in breast cancer risk prediction is unclear. To examine this, we measured total and high molecula...
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| Published in | PloS one Vol. 10; no. 6; p. e0129246 |
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| Main Authors | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
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United States
Public Library of Science
12.06.2015
Public Library of Science (PLoS) |
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| Abstract | The level of total adiponectin, a mixture of different adiponectin forms, has been reported associated with breast cancer risk with inconsistent results. Whether the different forms play different roles in breast cancer risk prediction is unclear. To examine this, we measured total and high molecular weight (HMW) adiponectin in a case-control study (1167 sets). Higher circulating HMW adiponectin was negatively associated with breast cancer risk after adjusting for menopausal status and family history of breast cancer (P=0.024). We analyzed the relationship between adiponectin and breast cancer risk in 6 subgroups. Higher circulating HMW adiponectin was also negatively associated with breast cancer risk (P=0.020, 0.014, 0.035) in the subgroups of postmenopausal women, negative family history of breast cancer, BMI>=24.0. Total adiponectin was positively associated with breast cancer (P=0.028) in the subgroup of BMI<=24.0. Higher HMW/total adiponectin ratio was negatively associated with breast cancer (P=0.019) in the subgroup of postmenopausal women. Interestingly, in the subgroup of women with family history of breast cancer, higher circulating total and HMW adiponectin were positively associated with breast cancer risk (P=0.034, 0.0116). This study showed different forms of circulating adiponectin levels might play different roles in breast cancer risk. A higher circulating HMW adiponectin is associated with a decreased breast cancer risk, especially in postmenopausal, without family history of breast cancer or BMI>=24.0 subgroups, whereas higher circulating HMW adiponectin levels is a risk factor in women with a family history of breast cancer. Further investigation of different forms of adiponectin on breast cancer risk is needed. |
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| AbstractList | The level of total adiponectin, a mixture of different adiponectin forms, has been reported associated with breast cancer risk with inconsistent results. Whether the different forms play different roles in breast cancer risk prediction is unclear. To examine this, we measured total and high molecular weight (HMW) adiponectin in a case-control study (1167 sets). Higher circulating HMW adiponectin was negatively associated with breast cancer risk after adjusting for menopausal status and family history of breast cancer (P=0.024). We analyzed the relationship between adiponectin and breast cancer risk in 6 subgroups. Higher circulating HMW adiponectin was also negatively associated with breast cancer risk (P=0.020, 0.014, 0.035) in the subgroups of postmenopausal women, negative family history of breast cancer, BMI>=24.0. Total adiponectin was positively associated with breast cancer (P=0.028) in the subgroup of BMI<=24.0. Higher HMW/total adiponectin ratio was negatively associated with breast cancer (P=0.019) in the subgroup of postmenopausal women. Interestingly, in the subgroup of women with family history of breast cancer, higher circulating total and HMW adiponectin were positively associated with breast cancer risk (P=0.034, 0.0116). This study showed different forms of circulating adiponectin levels might play different roles in breast cancer risk. A higher circulating HMW adiponectin is associated with a decreased breast cancer risk, especially in postmenopausal, without family history of breast cancer or BMI>=24.0 subgroups, whereas higher circulating HMW adiponectin levels is a risk factor in women with a family history of breast cancer. Further investigation of different forms of adiponectin on breast cancer risk is needed. The level of total adiponectin, a mixture of different adiponectin forms, has been reported associated with breast cancer risk with inconsistent results. Whether the different forms play different roles in breast cancer risk prediction is unclear. To examine this, we measured total and high molecular weight (HMW) adiponectin in a case-control study (1167 sets). Higher circulating HMW adiponectin was negatively associated with breast cancer risk after adjusting for menopausal status and family history of breast cancer ( P =0.024). We analyzed the relationship between adiponectin and breast cancer risk in 6 subgroups. Higher circulating HMW adiponectin was also negatively associated with breast cancer risk ( P =0.020, 0.014, 0.035) in the subgroups of postmenopausal women, negative family history of breast cancer, BMI>=24.0. Total adiponectin was positively associated with breast cancer ( P =0.028) in the subgroup of BMI<=24.0. Higher HMW/total adiponectin ratio was negatively associated with breast cancer ( P =0.019) in the subgroup of postmenopausal women. Interestingly, in the subgroup of women with family history of breast cancer, higher circulating total and HMW adiponectin were positively associated with breast cancer risk ( P =0.034, 0.0116). This study showed different forms of circulating adiponectin levels might play different roles in breast cancer risk. A higher circulating HMW adiponectin is associated with a decreased breast cancer risk, especially in postmenopausal, without family history of breast cancer or BMI>=24.0 subgroups, whereas higher circulating HMW adiponectin levels is a risk factor in women with a family history of breast cancer. Further investigation of different forms of adiponectin on breast cancer risk is needed. The level of total adiponectin, a mixture of different adiponectin forms, has been reported associated with breast cancer risk with inconsistent results. Whether the different forms play different roles in breast cancer risk prediction is unclear. To examine this, we measured total and high molecular weight (HMW) adiponectin in a case-control study (1167 sets). Higher circulating HMW adiponectin was negatively associated with breast cancer risk after adjusting for menopausal status and family history of breast cancer (P=0.024). We analyzed the relationship between adiponectin and breast cancer risk in 6 subgroups. Higher circulating HMW adiponectin was also negatively associated with breast cancer risk (P=0.020, 0.014, 0.035) in the subgroups of postmenopausal women, negative family history of breast cancer, BMI>=24.0. Total adiponectin was positively associated with breast cancer (P=0.028) in the subgroup of BMI<=24.0. Higher HMW/total adiponectin ratio was negatively associated with breast cancer (P=0.019) in the subgroup of postmenopausal women. Interestingly, in the subgroup of women with family history of breast cancer, higher circulating total and HMW adiponectin were positively associated with breast cancer risk (P=0.034, 0.0116). This study showed different forms of circulating adiponectin levels might play different roles in breast cancer risk. A higher circulating HMW adiponectin is associated with a decreased breast cancer risk, especially in postmenopausal, without family history of breast cancer or BMI>=24.0 subgroups, whereas higher circulating HMW adiponectin levels is a risk factor in women with a family history of breast cancer. Further investigation of different forms of adiponectin on breast cancer risk is needed.The level of total adiponectin, a mixture of different adiponectin forms, has been reported associated with breast cancer risk with inconsistent results. Whether the different forms play different roles in breast cancer risk prediction is unclear. To examine this, we measured total and high molecular weight (HMW) adiponectin in a case-control study (1167 sets). Higher circulating HMW adiponectin was negatively associated with breast cancer risk after adjusting for menopausal status and family history of breast cancer (P=0.024). We analyzed the relationship between adiponectin and breast cancer risk in 6 subgroups. Higher circulating HMW adiponectin was also negatively associated with breast cancer risk (P=0.020, 0.014, 0.035) in the subgroups of postmenopausal women, negative family history of breast cancer, BMI>=24.0. Total adiponectin was positively associated with breast cancer (P=0.028) in the subgroup of BMI<=24.0. Higher HMW/total adiponectin ratio was negatively associated with breast cancer (P=0.019) in the subgroup of postmenopausal women. Interestingly, in the subgroup of women with family history of breast cancer, higher circulating total and HMW adiponectin were positively associated with breast cancer risk (P=0.034, 0.0116). This study showed different forms of circulating adiponectin levels might play different roles in breast cancer risk. A higher circulating HMW adiponectin is associated with a decreased breast cancer risk, especially in postmenopausal, without family history of breast cancer or BMI>=24.0 subgroups, whereas higher circulating HMW adiponectin levels is a risk factor in women with a family history of breast cancer. Further investigation of different forms of adiponectin on breast cancer risk is needed. |
| Audience | Academic |
| Author | Liu, Shu-chen Yu, Zhi-gang Xiang, Yu-juan Guo, Ming-ming Cui, Shu-de Tian, Fu-guo Li, Guo-lou Li, Liang Ma, Dan-dan Geng, Cui-zhi Zhang, Jian-guo Yu, Li-xiang Wang, Hai-bo Tang, Jin-hai Zhu, Shi-guang Liu, Lu Fan, Zhi-min Liang, Hong Wang, Qi-tang Cao, Xu-chen Jiang, Hong-chuan Yang, Zhen-lin Ye, Chun-miao Wang, Shu Ma, Zhong-bing Liu, Li-yuan Wang, Xiang Jin, Feng Wang, Fei Wang, Lu Zhou, Wen-zhong Zuo, Wen-shu Duan, Xue-ning |
| AuthorAffiliation | 14 Department of General Surgery, Nanjing Medical University Affiliated Cancer Hospital Cancer Institute of Jiangsu Province, Nanjing, Jiangsu, China 7 Breast Center, the Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China 8 Department of Breast Surgery, the First Hospital of Jilin University, Changchun, Jilin, China 16 Department of Thyroid and Breast Surgery, the First Affiliated hospital of Binzhou Medical University, Binzhou, Shandong, China University of South Alabama Mitchell Cancer Institute, UNITED STATES 10 Breast Disease Center, Peking University People's Hospital, Beijing, China 4 Department of Breast Surgery, Affiliated Tumor Hospital of Zhengzhou University, Zhengzhou, Henan, China 3 Breast Disease Center, Peking University First Hospital, Beijing, China 20 Department of Breast and Thyroid Surgery, Zibo Central Hospital, Zibo, Shandong, China 6 National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China 1 |
| AuthorAffiliation_xml | – name: 21 Department of Breast Surgery, Yantai Yuhuangding Hospital, Yantai, Shandong, China – name: 2 Department of Breast Surgery, the Second Hospital of Shandong University, Jinan, Shandong, China – name: 12 Department of General Surgery, the Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China – name: 3 Breast Disease Center, Peking University First Hospital, Beijing, China – name: 4 Department of Breast Surgery, Affiliated Tumor Hospital of Zhengzhou University, Zhengzhou, Henan, China – name: 5 Department of Breast Surgery, Shanxi Cancer Hospital, Taiyuan, Shanxi, China – name: 13 Department of Breast Surgery, the First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China – name: University of South Alabama Mitchell Cancer Institute, UNITED STATES – name: 1 School of Medicine, Shandong University, Jinan, Shandong, China – name: 17 Breast Center, Qingdao University Affiliated Hospital, Qingdao, Shandong, China – name: 6 National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China – name: 11 Department of General Surgery, Beijing Chaoyang Hospital, Beijing, China – name: 18 Department of Breast Surgery, the Second Affiliated Hospital of Qingdao Medical College, Qingdao Central Hospital, Qingdao, Shandong, China – name: 14 Department of General Surgery, Nanjing Medical University Affiliated Cancer Hospital Cancer Institute of Jiangsu Province, Nanjing, Jiangsu, China – name: 24 Division of Epidemiology and Biostatistics, School of Public Health, Shandong University, Jinan, Shandong, China – name: 16 Department of Thyroid and Breast Surgery, the First Affiliated hospital of Binzhou Medical University, Binzhou, Shandong, China – name: 10 Breast Disease Center, Peking University People's Hospital, Beijing, China – name: 23 Epidemiology Institute, School of Public Health, Shandong University, Jinan, Shandong, China – name: 15 Department of General Surgery, Linyi People’s Hospital, Linyi, Shandong, China – name: 7 Breast Center, the Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China – name: 20 Department of Breast and Thyroid Surgery, Zibo Central Hospital, Zibo, Shandong, China – name: 8 Department of Breast Surgery, the First Hospital of Jilin University, Changchun, Jilin, China – name: 9 Department of Breast Surgery, Cancer Hospital, Chinese Academy of Medical Sciences, Beijing, China – name: 19 Department of Breast and Thyroid Surgery, Weifang Traditional Chinese Hospital, Weifang, Shandong, China – name: 22 Breast Cancer Center, Shandong Cancer Hospital, Jinan, Shandong, China |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/26070203$$D View this record in MEDLINE/PubMed |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Competing Interests: The authors have declared that no competing interests exist. Conceived and designed the experiments: MMG LYL ZGY. Performed the experiments: MMG XND SDC FGT XCC CZG ZMF XW SW HCJ JGZ FJ JHT HL ZLY HBW QTW GLL LiangL SGZ WSZ DDM SCL YJX CMY FW LXY ZGY. Analyzed the data: MMG LYL LW. Contributed reagents/materials/analysis tools: LuL WZZ ZBM. Wrote the paper: MMG LYL ZGY. Supplied suggestion on study design as well as manuscript preparation: ZGY. |
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| SubjectTerms | Adiponectin Adiponectin - blood Adiponectin - chemistry Adult Aged Body mass Breast cancer Breast Neoplasms - blood Breast Neoplasms - diagnosis Breast Neoplasms - etiology Cancer Cancer research Case studies Case-Control Studies China Diabetes Epidemiology Female Genetics Health risk assessment Health risks Hospitals Humans Kinases Medical diagnosis Medicine Menarche Menopause Metabolism Middle Aged Molecular chains Molecular Weight Obesity Post-menopause Postmenopausal women Prognosis Public health Risk Risk factors Subgroups Surgery Thyroid gland Weight control Womens health |
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| Title | Circulating High-Molecular-Weight (HMW) Adiponectin Level Is Related with Breast Cancer Risk Better than Total Adiponectin: A Case-Control Study |
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