Axon initial segment geometry in relation to motoneuron excitability

• Published in: PloS one Vol. 16; no. 11; p. e0259918
• Main Authors: Rotterman, Travis M, Carrasco, Darío I, Housley, Stephen N, Nardelli, Paul, Powers, Randall K, Cope, Timothy C
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 19.11.2021; Public Library of Science (PLoS)
• Subjects: Action potential; Action Potentials - physiology; Analysis; Animals; Axon Initial Segment - metabolism; Axon Initial Segment - pathology; Axon Initial Segment - physiology; Axons; Axons - metabolism; Axons - pathology; Biology and Life Sciences; Car pools; Constellations; Electrophysiology; Excitability; Geometry; Heterogeneity; Hypotheses; Hypothesis; Immunohistochemistry; In vivo methods and tests; Male; Medicine and Health Sciences; Motor neurons; Motor Neurons - metabolism; Motor Neurons - pathology; Motor Neurons - physiology; Motor units; Muscles - physiology; Neural Conduction; Neurons; Neurons, Efferent - physiology; Physical Sciences; Physiology; Rats; Rats, Wistar; Recruitment; Segments; Spinal cord; Spinal Cord - physiology; Spinal plasticity; United States; Atlanta Georgia; United States > US; Georgia

The axon initial segment (AIS) responsible for action potential initiation is a dynamic structure that varies and changes together with neuronal excitability. Like other neuron types, alpha motoneurons in the mammalian spinal cord express heterogeneity and plasticity in AIS geometry, including lengt...