Elevated Plasma Levels of the Pituitary Hormone Cthrc1 in Individuals with Red Hair but Not in Patients with Solid Tumors

• Published in: PloS one Vol. 9; no. 6; p. e100449
• Main Authors: Duarte, Christine W., Stohn, J. Patrizia, Wang, Qiaozeng, Emery, Ivette F., Prueser, Andrew, Lindner, Volkhard
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 19.06.2014; Public Library of Science (PLoS)
• Subjects: Adult; Angiotensin; Angiotensin II; Angiotensins; Animals; Antibodies, Monoclonal - metabolism; Anticoagulants; Biology and Life Sciences; Cancer; Collagen; Colon; Consent; Demography; Diabetes mellitus; Endometrium; Enzyme-linked immunosorbent assay; Extracellular Matrix Proteins - blood; Extracellular Matrix Proteins - immunology; Female; Fibroblasts; Gastric cancer; Genetic engineering; Hair; Hair Color; Human subjects; Humans; Hypertension; Immunoglobulins; Immunohistochemistry; Inflammation; Kidneys; Laboratory animals; Lobes; Lung cancer; Male; Medical diagnosis; Medicine; Melanocortin; Melanocyte-stimulating hormone; Melanoma; Mice, Transgenic; Middle Aged; Models, Animal; Monoclonal antibodies; Neoplasms - blood; Neoplasms - metabolism; Pancreas; Pancreatic cancer; Patients; Peptides; Pituitary; Pituitary Gland - metabolism; Pituitary hormones; Pituitary Hormones - blood; Plasma levels; Primary care; Protein Transport; Rats; Regulation; Rodents; Skin; Skin cancer; Skin diseases; Solid tumors; Stomach cancer; Stromal Cells - metabolism; Stromal Cells - pathology; Tissues; Transgenic animals; Transgenic mice; Tumors; Veins & arteries; Wound healing

An increasing number of studies report that Cthrc1 is expressed in various cancer cells. The present study sought to identify which cells in tumors and remodeling tissues express Cthrc1 and investigate the range of circulating human Cthrc1 levels in health and disease. Highly specific monoclonal ant...