Receptor for Advanced Glycation End-Products Signaling Interferes with the Vascular Smooth Muscle Cell Contractile Phenotype and Function

• Published in: PloS one Vol. 10; no. 8; p. e0128881
• Main Authors: Simard, Elie, Söllradl, Thomas, Maltais, Jean-Sébastien, Boucher, Julie, D’Orléans-Juste, Pédro, Grandbois, Michel
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 06.08.2015; Public Library of Science (PLoS)
• Subjects: Advanced glycosylation end products; Age; Animals; Biomechanical Phenomena; Blood; Blood circulation; Blood plasma; Calcium; Calcium - metabolism; Calcium signalling; Cancer; Cell activation; Cell Line; Cellular signal transduction; Complications; Contraction; Diabetes; Diabetes Complications - etiology; Diabetes Complications - metabolism; Diabetes mellitus; Endothelial cells; Extracellular matrix; G proteins; Glucose; Glycation End Products, Advanced - metabolism; Glycosylation; Humans; Hyperglycemia; Hypertension; Inflammation; Kinases; MAP kinase; Muscle Contraction; Muscle, Smooth, Vascular - cytology; Muscle, Smooth, Vascular - metabolism; Muscle, Smooth, Vascular - physiology; Muscles; Myosin; NF-kappa B - metabolism; NF-κB protein; Nuclear reactions; Phenotypes; Proteins; Rats; Receptor for Advanced Glycation End Products - metabolism; Rigidity; Serum Albumin - metabolism; Signal Transduction; Smooth muscle; Transcription factors; Vascular diseases; Vascular Diseases - etiology; Vascular Diseases - metabolism; Vascular smooth muscle; Vasopressin; Canada

Increased blood glucose concentrations promote reactions between glucose and proteins to form advanced glycation end-products (AGE). Circulating AGE in the blood plasma can activate the receptor for advanced end-products (RAGE), which is present on both endothelial and vascular smooth muscle cells (...