Grape Seed Proanthocyanidin Extract Ameliorates Diabetic Bladder Dysfunction via the Activation of the Nrf2 Pathway

• Published in: PloS one Vol. 10; no. 5; p. e0126457
• Main Authors: Chen, Shouzhen, Zhu, Yaofeng, Liu, Zhifeng, Gao, Zhaoyun, Li, Baoying, Zhang, Dongqing, Zhang, Zhaocun, Jiang, Xuewen, Liu, Zhengfang, Meng, Lingquan, Yang, Yue, Shi, Benkang
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 14.05.2015; Public Library of Science (PLoS)
• Subjects: Analysis; Animals; Antioxidants; Antioxidants (Nutrients); Apoptosis; Apoptosis - drug effects; BAX protein; Bcl-2 protein; Bladder; Care and treatment; Caspase; Caspase-3; Chromatography; Complications and side effects; Diabetes; Diabetes Complications - drug therapy; Diabetes Complications - pathology; Diabetes Complications - physiopathology; Diabetes mellitus; Diabetes Mellitus, Experimental - complications; DNA nucleotidylexotransferase; Female; Grape Seed Extract - therapeutic use; Growth factors; Health aspects; Hyperglycemia; Metabolism; Nerve growth factor; Neuroprotection; NF-E2-Related Factor 2 - metabolism; Oxidative stress; Oxidative Stress - drug effects; Pharmacology; Plant extracts; Proanthocyanidins; Proanthocyanidins - therapeutic use; Proteins; Rats; Rats, Wistar; Rodents; Signal Transduction - drug effects; Smooth muscle; Streptozocin; Studies; Urinary bladder; Urinary Bladder - drug effects; Urinary Bladder - pathology; Urinary Bladder - physiopathology; Urology; China

Diabetes Mellitus (DM)-induced bladder dysfunction is predominantly due to the long-term oxidative stress caused by hyperglycemia. Grape seed proanthocyanidin extract (GSPE) has been reported to possess a broad spectrum of pharmacological and therapeutic properties against oxidative stress. However,...