Single nucleotide polymorphisms associated with elevated alanine aminotransferase in patients receiving asunaprevir plus daclatasvir combination therapy for chronic hepatitis C

• Published in: PloS one Vol. 14; no. 7; p. e0219022
• Main Authors: Kato, Keizo, Shimada, Noritomo, Atsukawa, Masanori, Abe, Hiroshi, Itokawa, Norio, Matsumoto, Yoshihiro, Agata, Rie, Tsubota, Akihito
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 10.07.2019; Public Library of Science (PLoS)
• Subjects: Adult; Aged; Aged, 80 and over; Alanine; Alanine aminotransferase; Alanine transaminase; Alanine Transaminase - blood; Alleles; Amino acids; Antiviral agents; Antiviral drugs; Biology and life sciences; Care and treatment; Chemical and Drug Induced Liver Injury - blood; Chemical and Drug Induced Liver Injury - genetics; Chromosomes; Chronic infection; Cirrhosis; Combination therapy; Cytochrome; Cytochrome P-450; Cytochrome P-450 CYP3A - genetics; Diagnosis; Disease control; Drug dosages; Drug metabolism; Drug Therapy, Combination - adverse effects; Enzymes; Female; Gastroenterology; Genes; Genetic polymorphisms; Genotype; Genotype & phenotype; Genotypes; Genotyping; Health risk assessment; Hepacivirus - genetics; Hepatitis; Hepatitis C; Hepatitis C virus; Hepatitis C, Chronic - blood; Hepatitis C, Chronic - drug therapy; Hepatitis C, Chronic - genetics; Hepatology; Hospitals; Humans; Imidazoles - administration & dosage; Imidazoles - adverse effects; Imidazoles - pharmacokinetics; Imidazoles - therapeutic use; Infection; Infections; Interferon; Internal medicine; Isoquinolines - administration & dosage; Isoquinolines - adverse effects; Isoquinolines - pharmacokinetics; Japan; Laboratories; Liver; Liver cirrhosis; Liver diseases; Male; Medical research; Medicine; Medicine and health sciences; Metabolism; Middle Aged; Multivariate Analysis; Nucleotides; Patient monitoring equipment; Pharmacokinetics; Pharmacology; Polymorphism, Single Nucleotide; Prostate cancer; Single nucleotide polymorphisms; Single-nucleotide polymorphism; Sulfonamides - administration & dosage; Sulfonamides - adverse effects; Sulfonamides - pharmacokinetics; Therapy; Up-Regulation; Viruses; Japan

Drug-induced liver damage characterized by serum alanine aminotransferase (ALT) elevation often occurs in direct-acting antiviral (DAA) combination therapy for chronic hepatitis C virus (HCV) infection. This study explored single nucleotide polymorphisms (SNPs) at drug metabolism- or transport-relat...