Mechanisms of the Incretin Effect in Subjects with Normal Glucose Tolerance and Patients with Type 2 Diabetes

• Published in: PloS one Vol. 8; no. 9; p. e73154
• Main Authors: Mari, Andrea, Bagger, Jonatan I., Ferrannini, Ele, Holst, Jens J., Knop, Filip K., Vilsbøll, Tina
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 03.09.2013; Public Library of Science (PLoS)
• Subjects: Aged; Analysis; Biology; Blood Glucose - analysis; Diabetes; Diabetes mellitus; Diabetes Mellitus, Type 2 - physiopathology; Dosage; Drug dosages; Embedding; Female; Glucose; Glucose tolerance; Glucose Tolerance Test; Humans; Incretins - physiology; Insulin; Insulin - metabolism; Insulin Resistance; Insulin Secretion; Intravenous administration; Islets of Langerhans - physiopathology; Male; Medicine; Metabolism; Methods; Middle Aged; Peptides; Potentiation; Rodents; Secretion; Sensitivity; Sensitivity analysis; Sensitivity enhancement; Studies; Type 2 diabetes; Denmark

The incretin effect on insulin secretion was investigated in 8 subjects with type 2 diabetes (T2D) and 8 with normal glucose tolerance (NGT), using 25, 75, and 125 g oral glucose tolerance tests (OGTT) and isoglycemic intravenous glucose infusions (IIGI). The ß-cell response was evaluated using a mo...