A Conserved BDNF, Glutamate- and GABA-Enriched Gene Module Related to Human Depression Identified by Coexpression Meta-Analysis and DNA Variant Genome-Wide Association Studies

• Published in: PloS one Vol. 9; no. 3; p. e90980
• Main Authors: Chang, Lun-Ching, Jamain, Stephane, Lin, Chien-Wei, Rujescu, Dan, Tseng, George C., Sibille, Etienne
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 07.03.2014; Public Library of Science (PLoS)
• Subjects: Aged; Analysis; Anopheles; Bioinformatics; Biology; Bipolar disorder; Brain; Brain - metabolism; Brain - physiopathology; Brain research; Brain-Derived Neurotrophic Factor - genetics; Brain-Derived Neurotrophic Factor - metabolism; Case-Control Studies; Cell Adhesion Molecules, Neuronal - genetics; Cell Adhesion Molecules, Neuronal - metabolism; Deoxyribonucleic acid; Depression (Mood disorder); Depressive Disorder, Major - genetics; Depressive Disorder, Major - metabolism; Depressive Disorder, Major - physiopathology; Disease; DNA; Epidemiology; Extracellular Matrix Proteins - genetics; Extracellular Matrix Proteins - metabolism; Female; GABA; Gene expression; Gene Expression Profiling; Gene Expression Regulation; Gene Regulatory Networks; Genes; Genetic aspects; Genetic Predisposition to Disease; Genetics; Genome, Human; Genome-wide association studies; Genome-Wide Association Study; Genomes; Genomics; Glutamate; Heterogeneity; Humans; Hypotheses; Male; Medical research; Medicine; Mental depression; Meta-analysis; Metabolic Networks and Pathways - genetics; Middle Aged; Multigene Family; Nerve Tissue Proteins - genetics; Nerve Tissue Proteins - metabolism; Nervous system diseases; Neurosciences; Noise control; Psychiatry; Receptors, Eph Family - genetics; Receptors, Eph Family - metabolism; Receptors, GABA - genetics; Receptors, GABA - metabolism; Receptors, Metabotropic Glutamate - genetics; Receptors, Metabotropic Glutamate - metabolism; Reelin Protein; Serine Endopeptidases - genetics; Serine Endopeptidases - metabolism; Single nucleotide polymorphisms; Studies; Transcriptome

Large scale gene expression (transcriptome) analysis and genome-wide association studies (GWAS) for single nucleotide polymorphisms have generated a considerable amount of gene- and disease-related information, but heterogeneity and various sources of noise have limited the discovery of disease mech...