Nanofibrous scaffolds for the guidance of stem cell-derived neurons for auditory nerve regeneration

• Published in: PloS one Vol. 12; no. 7; p. e0180427
• Main Authors: Hackelberg, Sandra, Tuck, Samuel J., He, Long, Rastogi, Arjun, White, Christina, Liu, Liqian, Prieskorn, Diane M., Miller, Ryan J., Chan, Che, Loomis, Benjamin R., Corey, Joseph M., Miller, Josef M., Duncan, R. Keith
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 03.07.2017; Public Library of Science (PLoS)
• Subjects: Alignment; Animals; Auditory nerve; Biocompatibility; Biocompatible Materials; Biology and Life Sciences; Biomedical engineering; Biomedical materials; Brain stem; Brain Stem - physiology; Cell Differentiation; Cell survival; Cell Transplantation; Cellulose; Circuit design; Cochlear Nerve - physiology; Deafness - therapy; Education; Embryo cells; Embryonic Stem Cells - cytology; Engineering and Technology; Female; Ganglion cells; Gene expression; Genetic aspects; Geriatrics; Glutamatergic transmission; Green Fluorescent Proteins - genetics; Guinea Pigs; Hair; Health aspects; Hearing loss; Humans; In vitro methods and tests; Inflammation; Inflammatory response; Integration; Male; Mammals; Mats; Medical imaging; Medicine and Health Sciences; Mineralization; Nanofibers; Nerve regeneration; Nerve Regeneration - physiology; Neurogenesis; Neurons; Neurons - cytology; Otolaryngology; Ouabain; Physical Sciences; Physiological aspects; Polymers; Regeneration; Research and Analysis Methods; Risk factors; Scaffolds; Schwann cells; Spiral ganglion; Stem cell transplantation; Stem cells; Surgery; Surgical implants; Survival; Therapy; Thresholds; Tissue Engineering; Transplants & implants; Ann Arbor Michigan; United States > US

Impairment of spiral ganglion neurons (SGNs) of the auditory nerve is a major cause for hearing loss occurring independently or in addition to sensory hair cell damage. Unfortunately, mammalian SGNs lack the potential for autonomous regeneration. Stem cell based therapy is a promising approach for a...