Dynamics of DNA methylation during early development of the preimplantation bovine embryo

• Published in: PloS one Vol. 8; no. 6; p. e66230
• Main Authors: Dobbs, Kyle B, Rodriguez, Marlon, Sudano, Mateus J, Ortega, M Sofia, Hansen, Peter J
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 14.06.2013; Public Library of Science (PLoS)
• Subjects: Agriculture; Analysis; Animal sciences; Animals; Biology; Blastocyst - physiology; Blastocysts; Bovidae; Cattle; CDX2 protein; Cell lineage; Colony-stimulating factor; CpG islands; Deoxyribonucleic acid; Developmental stages; Divergence; DNA; DNA (Cytosine-5-)-Methyltransferases - genetics; DNA (Cytosine-5-)-Methyltransferases - metabolism; DNA Methylation; Embryo; Embryo Culture Techniques; Embryonic Development; Embryos; Epigenesis, Genetic; Epigenetic inheritance; Epigenetics; Female; Females; Fertilization; Gene Expression; Gene Expression Regulation, Developmental; Genetics; Genomes; Granulocytes; Introns; Labeling; Labelling; Male; Males; Mammals; Methylation; Methyltransferases; Pregnancy; Pyrimidines; RNA; RNA, Messenger - genetics; RNA, Messenger - metabolism; Sex Characteristics; Sheep; Sperm; Transition Temperature; Trophectoderm; Veterinary Science; Florida; United States > US

There is species divergence in control of DNA methylation during preimplantation development. The exact pattern of methylation in the bovine embryo has not been established nor has its regulation by gender or maternal signals that regulate development such as colony stimulating factor 2 (CSF2). Usin...