Multi-centre evaluation of the Determine HIV Combo assay when used for point of care testing in a high risk clinic-based population

• Published in: PloS one Vol. 9; no. 4; p. e94062
• Main Authors: Conway, Damian P, Holt, Martin, McNulty, Anna, Couldwell, Deborah L, Smith, Don E, Davies, Stephen C, Cunningham, Philip, Keen, Phillip, Guy, Rebecca
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.04.2014; Public Library of Science (PLoS)
• Subjects: Adult; Ambulatory Care Facilities; Analysis; Antigens; Biology and Life Sciences; Bisexual; Bisexuality; Care and treatment; Clinics; Comparative analysis; Diagnosis; Evaluation; Health aspects; Health risks; Health services; HIV; HIV antibodies; HIV Antibodies - immunology; HIV infection; HIV Infections - diagnosis; HIV Infections - immunology; HIV Seropositivity - diagnosis; HIV Seropositivity - immunology; Hospitals; Human immunodeficiency virus; Humans; Immunoassay; Infections; Infectious diseases; Laboratories; Male; Mass Screening; Medical diagnosis; Medical tests; Medicine and health sciences; Mens health; p24 Protein; Patients; Public health; Reagent Kits, Diagnostic - standards; Research and Analysis Methods; Ribonucleic acid; Risk factors; RNA; Sensitivity; Sensitivity and Specificity; Serology; Sexually transmitted diseases; Studies; Virology; Australia

Determine HIV Combo (DHC) is the first point of care assay designed to increase sensitivity in early infection by detecting both HIV antibody and antigen. We conducted a large multi-centre evaluation of DHC performance in Sydney sexual health clinics. We compared DHC performance (overall, by test co...