Co-localization of acinar markers and insulin in pancreatic cells of subjects with type 2 diabetes

• Published in: PloS one Vol. 12; no. 6; p. e0179398
• Main Authors: Masini, Matilde, Marselli, Lorella, Himpe, Eddy, Martino, Luisa, Bugliani, Marco, Suleiman, Mara, Boggi, Ugo, Filipponi, Franco, Occhipinti, Margherita, Bouwens, Luc, De Tata, Vincenzo, Marchetti, Piero
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 15.06.2017; Public Library of Science (PLoS)
• Subjects: Aged; Amylases; Beta cells; Biology and Life Sciences; Biomarkers - metabolism; Carboxypeptidase A; Conversion; Diabetes; Diabetes mellitus; Diabetes Mellitus, Type 2 - metabolism; Diabetes Mellitus, Type 2 - pathology; Electron microscopy; Enzymes; Female; Gene expression; Granular materials; Granules; Humans; Immune system; Immunofluorescence; Innate immunity; Insulin; Insulin - metabolism; Labels; Laboratories; Light microscopy; Localization; Macrophages; Male; Markers; Marking; Mast cells; Medicine; Medicine and Health Sciences; Middle Aged; Pancreas; Pancreas transplantation; Pancreas, Exocrine - metabolism; Pancreas, Exocrine - ultrastructure; Pancreatic beta cells; Patients; Physiological aspects; Proenzymes; Research and Analysis Methods; Rodents; Searching; Stem cells; Studies; Surgery; Type 2 diabetes

To search for clues suggesting that beta cells may generate by transdifferentiation in humans, we assessed the presence of cells double positive for exocrine (amylase, carboxypeptidase A) and endocrine (insulin) markers in the pancreas of non-diabetic individuals (ND) and patients with type 2 diabet...