Differential Contribution of Acute and Chronic Inflammation to the Development of Murine Mammary 4T1 Tumors

• Published in: PloS one Vol. 10; no. 7; p. e0130809
• Main Authors: Rodrigues Viana, Celso Tarso, Castro, Pollyana Ribeiro, Marques, Suzane Motta, Paz Lopes, Miriam Teresa, Gonçalves, Ricardo, Campos, Paula Peixoto, Andrade, Silvia Passos
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 09.07.2015; Public Library of Science (PLoS)
• Subjects: Acetylglucosaminidase - immunology; Acetylglucosaminidase - metabolism; Acute Disease; Analysis; Angiogenesis; Animals; Biomarkers, Tumor - immunology; Biomarkers, Tumor - metabolism; Biophysics; Breast cancer; Cancer; Chemokines; Chronic Disease; Cytokines; Dendritic cells; Development and progression; Disease Progression; Enzymes; Flow Cytometry; Growth factors; Implantation; Implants; Inflammation; Inflammation - immunology; Inflammation - metabolism; Leukocytes; Leukocytes (neutrophilic); Lymphocytes; Lymphocytes - immunology; Lymphocytes - metabolism; Macrophages; Macrophages - immunology; Macrophages - metabolism; Male; Mammary gland; Mammary Neoplasms, Experimental - blood supply; Mammary Neoplasms, Experimental - immunology; Mammary Neoplasms, Experimental - metabolism; Markers; Metastasis; Mice, Inbred BALB C; Monocytes; Monocytes - immunology; Monocytes - metabolism; N-Acetylglucosaminidase; Neovascularization, Pathologic - immunology; Neovascularization, Pathologic - metabolism; Neutrophils; Neutrophils - immunology; Neutrophils - metabolism; Pathology; Peroxidase - immunology; Peroxidase - metabolism; Physiology; Polyurethane; Polyurethane resins; Polyurethanes; Rodents; Time Factors; Transplants & implants; Tumor Burden - immunology; Tumor cells; Tumor Necrosis Factor-alpha - immunology; Tumor Necrosis Factor-alpha - metabolism; Tumor necrosis factor-α; Tumorigenesis; Tumors; Vascular endothelial growth factor; Vascular Endothelial Growth Factor A - immunology; Vascular Endothelial Growth Factor A - metabolism

Based on the notion that inflammation favors tumorigenesis, our experiments comparatively assessed the influence of acute and chronic inflammation on the development of a murine mammary tumor (4T1). In addition, we characterized angiogenic and inflammatory markers in the tumor tissue and systemicall...