Protein Distributions from a Stochastic Model of the lac Operon of E. coli with DNA Looping: Analytical solution and comparison with experiments

• Published in: PloS one Vol. 9; no. 7; p. e102580
• Main Authors: Choudhary, Krishna, Oehler, Stefan, Narang, Atul
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 23.07.2014; Public Library of Science (PLoS)
• Subjects: Algorithms; Biology and Life Sciences; Biotechnology; Bursting; Bursts; Chromosomes; Deoxyribonucleic acid; DNA; DNA, Bacterial - chemistry; DNA, Bacterial - genetics; E coli; Escherichia coli; Escherichia coli - genetics; Escherichia coli - metabolism; Escherichia coli Proteins - genetics; Escherichia coli Proteins - metabolism; Experiments; Feedback, Physiological; Gene expression; Gene Expression Regulation, Bacterial; Lac Operon; Lac Repressors - genetics; Lac Repressors - metabolism; Lactose operon; Ligands; Models, Genetic; Noise; Nucleic Acid Conformation; Operator Regions, Genetic - genetics; Operators; Permease; Physical Sciences; Proteins; RNA, Messenger - genetics; RNA, Messenger - metabolism; Stochastic models; Stochastic Processes; Stochasticity; India

Although noisy gene expression is widely accepted, its mechanisms are subjects of debate, stimulated largely by single-molecule experiments. This work is concerned with one such study, in which Choi et al., 2008, obtained real-time data and distributions of Lac permease in E. coli. They observed sma...