Haploinsufficiency of the Sec7 guanine nucleotide exchange factor gea1 impairs septation in fission yeast

• Published in: PloS one Vol. 8; no. 2; p. e56807
• Main Authors: Eckler, Alan M, Wilder, Caroline, Castanon, Antonio, Ferris, Veronica M, Lamere, Rachael A, Perrin, Benjamin A, Pearlman, Ross, White, Blaise, Byrd, Clifton, Ludvik, Nicholas, Nichols, Nona, Poole-Sumrall, Kristen, Sztul, Elizabeth, Styers, Melanie L
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 15.02.2013; Public Library of Science (PLoS)
• Subjects: Adenosine diphosphate; ADP-Ribosylation Factors - metabolism; Biological Transport - drug effects; Biological Transport - genetics; Biology; Brefeldin A; Brefeldin A - pharmacology; Cell cycle; Cell Division - drug effects; Cell Division - genetics; Coat protein; Contractility; Cytokinesis; Cytokinesis - drug effects; Cytokinesis - genetics; Defects; Endoplasmic reticulum; Fission; GDP/GTP exchange factors; Genes; Golgi apparatus; Guanine; Guanine nucleotide exchange factor; Guanine Nucleotide Exchange Factors - antagonists & inhibitors; Guanine Nucleotide Exchange Factors - deficiency; Guanine Nucleotide Exchange Factors - genetics; Haploinsufficiency; Homology; Insects; Kinases; Lipids; Localization; Membrane trafficking; Membranes; Morphology; Mutation; Organelles; Organelles - drug effects; Organelles - genetics; Proteins; Ribosylation; Schizosaccharomyces - cytology; Schizosaccharomyces - drug effects; Schizosaccharomyces - enzymology; Schizosaccharomyces - genetics; Schizosaccharomyces pombe; Septation; Yeast

Membrane trafficking is essential to eukaryotic life and is controlled by a complex network of proteins that regulate movement of proteins and lipids between organelles. The GBF1/GEA family of Guanine nucleotide Exchange Factors (GEFs) regulates trafficking between the endoplasmic reticulum and Golg...