T-type calcium channel enhancer SAK3 promotes dopamine and serotonin releases in the hippocampus in naive and amyloid precursor protein knock-in mice

• Published in: PloS one Vol. 13; no. 12; p. e0206986
• Main Authors: Wang, Shuo, Yabuki, Yasushi, Matsuo, Kazuya, Xu, Jing, Izumi, Hisanao, Sakimura, Kenji, Saito, Takashi, Saido, Takaomi C, Fukunaga, Kohji
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 20.12.2018; Public Library of Science (PLoS)
• Subjects: Acetylcholine receptors (nicotinic); Alzheimer's disease; Alzheimers disease; Amyloid beta-Protein Precursor - genetics; Amyloid precursor protein; Animal cognition; Animals; Biology and Life Sciences; Brain; CA1 Region, Hippocampal - drug effects; CA1 Region, Hippocampal - metabolism; CA1 Region, Hippocampal - physiology; Calcium; Calcium channels; Calcium channels (T-type); Calcium Channels, T-Type - deficiency; Calcium Channels, T-Type - genetics; Calcium Channels, T-Type - metabolism; Cognition - drug effects; Cognitive ability; Cyclopentane; Dementia; Development and progression; Dopamine; Dopamine - metabolism; Drug therapy; Epilepsy; Gene Knock-In Techniques; Gene Knockout Techniques; Genetic aspects; Hippocampus; Imidazoles - pharmacology; Kinases; Laboratories; Male; Medicine and Health Sciences; Methyllycaconitine; Mice; Monoamines; Neurosciences; Noradrenaline; Norepinephrine; Oral administration; Pain; Pathophysiology; Pharmaceutical sciences; Pharmacology; Physical Sciences; Physiological aspects; Physiology; Precursors; Prefrontal cortex; Proteins; Pyridines; Research and Analysis Methods; Saito, Takashi; Serotonin; Serotonin - metabolism; Sleep; Spiro Compounds - pharmacology; Japan; United Kingdom > UK

T-type calcium channels in the brain mediate the pathophysiology of epilepsy, pain, and sleep. Recently, we developed a novel therapeutic candidate, SAK3 (ethyl 8'-methyl-2',4-dioxo-2-(piperidin-1-yl)-2'H-spiro[cyclopentane-1,3'-imidazo[1,2-a] pyridine]-2-ene-3-carboxylate), for...