Effect of advanced periodontal self-care in patients with early-stage periodontal diseases on endothelial function: An open-label, randomized controlled trial

Although a significant association between periodontal disease and atherosclerotic cardiovascular disease has been reported, their cause-to-effect relationship remains controversial. This randomized controlled clinical trial aimed to investigate the effect of advanced self-care on atherosclerotic ca...

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Published inPloS one Vol. 16; no. 9; p. e0257247
Main Authors Okada, Ayako, Murata, Takatoshi, Matin, Khairul, Ariyoshi, Meu, Otsuka, Ryoko, Yamashita, Mamiko, Suzuki, Masayuki, Wakiyama, Rumi, Tateno, Ken, Suzuki, Megumi, Aoyagi, Hitomi, Uematsu, Hiromi, Imamura, Akiko, Kosaka, Miki, Mizukaki, Tomoko, Sato, Tsutomu, Kawahara, Hiroshi, Hanada, Nobuhiro
Format Journal Article
LanguageEnglish
Published United States Public Library of Science 23.09.2021
Public Library of Science (PLoS)
Subjects
Activities of daily living
Adult
Aged
Anesthesiology
Arginine - analogs & derivatives
Arginine - blood
Arteriosclerosis
Atherosclerosis
Atherosclerosis - complications
Atherosclerosis - prevention & control
Biology and Life Sciences
Biomarkers - blood
Brachial Artery - pathology
Cardiovascular disease
Cardiovascular diseases
Care and treatment
Clinical trials
Confidence intervals
Dental plaque
Dentistry
Dilatation, Pathologic
Disinfectants
Endothelium, Vascular - drug effects
Evaluation
Female
Follow-Up Studies
Gum disease
Health sciences
Hospitals
Humans
Hypotheses
Japan
Male
Mandible - physiology
Maxilla - physiology
Medicine
Medicine and Health Sciences
Middle Aged
Oral hygiene
Oral Hygiene - methods
Patients
People and Places
Periodontal disease
Periodontal diseases
Periodontal Diseases - prevention & control
Periodontal Diseases - therapy
Reduction
Research and Analysis Methods
Self Care
Self-care, Health
Social research
Treatment Outcome
Young Adult
Japan
Online AccessGet full text

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Abstract Although a significant association between periodontal disease and atherosclerotic cardiovascular disease has been reported, their cause-to-effect relationship remains controversial. This randomized controlled clinical trial aimed to investigate the effect of advanced self-care on atherosclerotic cardiovascular disease-related vascular function markers flow-mediated brachial artery dilatation (FMD) and serum asymmetric dimethylarginine (ADMA) level in patients with early-stage periodontal disease. The study was designed as a parallel group, 3-month follow-up, open-label, randomized controlled trial. The control group received standard care for periodontal diseases, whereas the test group additionally applied disinfectant using a custom-fabricated prescription tray for advanced self-care twice a day. Overall, 110 patients provided data for FMD and serum ADMA level. No significant improvements in FMD were observed in the control (mean increase, -0.1%; 95% confidence interval [CI], -1.0-0.8; P = 0.805) or test (mean increase, -0.3%; 95% CI, -1.1-0.4; P = 0.398) group. No significant changes in serum ADMA levels were observed (mean reduction, 0.01 μmol/L; 95% CI, -0.00-0.02; P = 0.366 and mean reduction, 0.00 μmol/L; 95% CI, -0.01-0.01; P = 0.349, respectively). No significant between-group differences were found in FMD (mean difference, -0.2%; 95% CI, -1.4-0.9; p = 0.708) or serum ADMA levels (mean difference, 0.01 nmol/L; 95% CI, -0.00-0.03; p = 0.122). Significant improvements in the average probing pocket depth were observed in the control and test groups. The bleeding on probing score in the test group was significantly reduced, while that in the control group was reduced, although not significantly. Periodontal care for a 3-month duration did not provide better endothelial function although improvements of periodontal status in patients with early-stage periodontal diseases. This trial is registered in UMIN Clinical Trials Registry (www.umin.ac.jp/ctr/; ID: UMIN000023395).
AbstractList Although a significant association between periodontal disease and atherosclerotic cardiovascular disease has been reported, their cause-to-effect relationship remains controversial. This randomized controlled clinical trial aimed to investigate the effect of advanced self-care on atherosclerotic cardiovascular disease-related vascular function markers flow-mediated brachial artery dilatation (FMD) and serum asymmetric dimethylarginine (ADMA) level in patients with early-stage periodontal disease. The study was designed as a parallel group, 3-month follow-up, open-label, randomized controlled trial. The control group received standard care for periodontal diseases, whereas the test group additionally applied disinfectant using a custom-fabricated prescription tray for advanced self-care twice a day. Overall, 110 patients provided data for FMD and serum ADMA level. No significant improvements in FMD were observed in the control (mean increase, −0.1%; 95% confidence interval [CI], −1.0–0.8; P = 0.805) or test (mean increase, −0.3%; 95% CI, −1.1–0.4; P = 0.398) group. No significant changes in serum ADMA levels were observed (mean reduction, 0.01 μmol/L; 95% CI, −0.00–0.02; P = 0.366 and mean reduction, 0.00 μmol/L; 95% CI, −0.01–0.01; P = 0.349, respectively). No significant between-group differences were found in FMD (mean difference, −0.2%; 95% CI, −1.4–0.9; p = 0.708) or serum ADMA levels (mean difference, 0.01 nmol/L; 95% CI, −0.00–0.03; p = 0.122). Significant improvements in the average probing pocket depth were observed in the control and test groups. The bleeding on probing score in the test group was significantly reduced, while that in the control group was reduced, although not significantly. Periodontal care for a 3-month duration did not provide better endothelial function although improvements of periodontal status in patients with early-stage periodontal diseases. This trial is registered in UMIN Clinical Trials Registry (www.umin.ac.jp/ctr/; ID: UMIN000023395).
Although a significant association between periodontal disease and atherosclerotic cardiovascular disease has been reported, their cause-to-effect relationship remains controversial. This randomized controlled clinical trial aimed to investigate the effect of advanced self-care on atherosclerotic cardiovascular disease-related vascular function markers flow-mediated brachial artery dilatation (FMD) and serum asymmetric dimethylarginine (ADMA) level in patients with early-stage periodontal disease. The study was designed as a parallel group, 3-month follow-up, open-label, randomized controlled trial. The control group received standard care for periodontal diseases, whereas the test group additionally applied disinfectant using a custom-fabricated prescription tray for advanced self-care twice a day. Overall, 110 patients provided data for FMD and serum ADMA level. No significant improvements in FMD were observed in the control (mean increase, -0.1%; 95% confidence interval [CI], -1.0-0.8; P = 0.805) or test (mean increase, -0.3%; 95% CI, -1.1-0.4; P = 0.398) group. No significant changes in serum ADMA levels were observed (mean reduction, 0.01 μmol/L; 95% CI, -0.00-0.02; P = 0.366 and mean reduction, 0.00 μmol/L; 95% CI, -0.01-0.01; P = 0.349, respectively). No significant between-group differences were found in FMD (mean difference, -0.2%; 95% CI, -1.4-0.9; p = 0.708) or serum ADMA levels (mean difference, 0.01 nmol/L; 95% CI, -0.00-0.03; p = 0.122). Significant improvements in the average probing pocket depth were observed in the control and test groups. The bleeding on probing score in the test group was significantly reduced, while that in the control group was reduced, although not significantly. Periodontal care for a 3-month duration did not provide better endothelial function although improvements of periodontal status in patients with early-stage periodontal diseases. This trial is registered in UMIN Clinical Trials Registry (www.umin.ac.jp/ctr/; ID: UMIN000023395).
Although a significant association between periodontal disease and atherosclerotic cardiovascular disease has been reported, their cause-to-effect relationship remains controversial. This randomized controlled clinical trial aimed to investigate the effect of advanced self-care on atherosclerotic cardiovascular disease-related vascular function markers flow-mediated brachial artery dilatation (FMD) and serum asymmetric dimethylarginine (ADMA) level in patients with early-stage periodontal disease. The study was designed as a parallel group, 3-month follow-up, open-label, randomized controlled trial. The control group received standard care for periodontal diseases, whereas the test group additionally applied disinfectant using a custom-fabricated prescription tray for advanced self-care twice a day. Overall, 110 patients provided data for FMD and serum ADMA level. No significant improvements in FMD were observed in the control (mean increase, −0.1%; 95% confidence interval [CI], −1.0–0.8; P = 0.805) or test (mean increase, −0.3%; 95% CI, −1.1–0.4; P = 0.398) group. No significant changes in serum ADMA levels were observed (mean reduction, 0.01 μmol/L; 95% CI, −0.00–0.02; P = 0.366 and mean reduction, 0.00 μmol/L; 95% CI, −0.01–0.01; P = 0.349, respectively). No significant between-group differences were found in FMD (mean difference, −0.2%; 95% CI, −1.4–0.9; p = 0.708) or serum ADMA levels (mean difference, 0.01 nmol/L; 95% CI, −0.00–0.03; p = 0.122). Significant improvements in the average probing pocket depth were observed in the control and test groups. The bleeding on probing score in the test group was significantly reduced, while that in the control group was reduced, although not significantly. Periodontal care for a 3-month duration did not provide better endothelial function although improvements of periodontal status in patients with early-stage periodontal diseases. This trial is registered in UMIN Clinical Trials Registry ( www.umin.ac.jp/ctr/ ; ID: UMIN000023395).
Although a significant association between periodontal disease and atherosclerotic cardiovascular disease has been reported, their cause-to-effect relationship remains controversial. This randomized controlled clinical trial aimed to investigate the effect of advanced self-care on atherosclerotic cardiovascular disease-related vascular function markers flow-mediated brachial artery dilatation (FMD) and serum asymmetric dimethylarginine (ADMA) level in patients with early-stage periodontal disease. The study was designed as a parallel group, 3-month follow-up, open-label, randomized controlled trial. The control group received standard care for periodontal diseases, whereas the test group additionally applied disinfectant using a custom-fabricated prescription tray for advanced self-care twice a day. Overall, 110 patients provided data for FMD and serum ADMA level. No significant improvements in FMD were observed in the control (mean increase, -0.1%; 95% confidence interval [CI], -1.0-0.8; P = 0.805) or test (mean increase, -0.3%; 95% CI, -1.1-0.4; P = 0.398) group. No significant changes in serum ADMA levels were observed (mean reduction, 0.01 [mu]mol/L; 95% CI, -0.00-0.02; P = 0.366 and mean reduction, 0.00 [mu]mol/L; 95% CI, -0.01-0.01; P = 0.349, respectively). No significant between-group differences were found in FMD (mean difference, -0.2%; 95% CI, -1.4-0.9; p = 0.708) or serum ADMA levels (mean difference, 0.01 nmol/L; 95% CI, -0.00-0.03; p = 0.122). Significant improvements in the average probing pocket depth were observed in the control and test groups. The bleeding on probing score in the test group was significantly reduced, while that in the control group was reduced, although not significantly. Periodontal care for a 3-month duration did not provide better endothelial function although improvements of periodontal status in patients with early-stage periodontal diseases. This trial is registered in UMIN Clinical Trials Registry (www.umin.ac.jp/ctr/; ID: UMIN000023395).
Audience Academic
Author Sato, Tsutomu
Kosaka, Miki
Wakiyama, Rumi
Ariyoshi, Meu
Otsuka, Ryoko
Tateno, Ken
Suzuki, Megumi
Kawahara, Hiroshi
Suzuki, Masayuki
Uematsu, Hiromi
Hanada, Nobuhiro
Yamashita, Mamiko
Okada, Ayako
Murata, Takatoshi
Aoyagi, Hitomi
Matin, Khairul
Imamura, Akiko
Mizukaki, Tomoko
AuthorAffiliation 9 Department of Dentistry, Tokyo Children Rehabilitation Hospital, Tokyo, Japan
11 Division of Basic Medical Science, Tokai University School of Medicine, Isehara, Japan
5 Department of Dental Anesthesiology, Tsurumi University School of Dental Medicine, Yokohama, Japan
4 Division of Oral Health Sciences, Graduate School of Medical and Dental Sciences, Department of Cariology and Operative Dentistry, Tokyo Medical and Dental University, Tokyo, Japan
7 Department of Dental Hygiene, The Nippon Dental University College at Tokyo, Tokyo, Japan
Danube Private University, AUSTRIA
3 Endowed Department of International Oral Health Science, Tsurumi University School of Dental Medicine, Yokohama, Japan
8 The Nippon Dental University Hospital, Tokyo, Japan
10 Department of Oral and Maxillofacial Surgery, St. Marianna University School of Medicine Kawasaki Municipal Tama Hospital, Kawasaki, Japan
6 Department of Anesthesiology, Saitama Medical University Hospital, Iruma-gun, Japan
1 Department of Translatio
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Cites_doi 10.2334/josnusd.48.111
10.1161/01.CIR.0000105764.22626.B1
10.1056/NEJMoa063186
10.1016/S0735-1097(03)00994-X
10.1016/S0021-9258(18)82227-X
10.1161/01.ATV.0000081742.92006.59
10.1016/j.archoralbio.2020.104997
10.2174/157340310791162659
10.1902/jop.2004.75.12.1694
10.1016/j.atherosclerosis.2014.06.002
10.1016/j.ahj.2005.10.002
10.1093/eurheartj/ehz646
10.1161/CIRCULATIONAHA.107.690016
10.1161/CIR.0b013e31825719f3
10.1111/j.1476-5381.1994.tb13026.x
10.1016/j.transci.2008.06.008
10.1111/j.1365-2362.2007.01781.x
10.1161/01.CIR.0000028581.07992.56
10.1177/0022034510375281
10.1111/j.1600-051X.2011.01710.x
10.1016/j.ejim.2006.12.003
10.1111/j.1365-2362.2005.01457.x
10.1111/odi.12909
10.1378/chest.127.6.2254
10.1007/s10554-010-9616-1
10.1074/jbc.M000023200
10.1111/jre.12860
10.1016/j.ahj.2004.09.059
ContentType Journal Article
Copyright COPYRIGHT 2021 Public Library of Science
2021 Okada et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
2021 Okada et al 2021 Okada et al
Copyright_xml – notice: COPYRIGHT 2021 Public Library of Science
– notice: 2021 Okada et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
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Competing Interests: Dr. Khairul Matin and Dr. Nobuhiro Hanada received a research grant from Medoc International Co. Ltd. Dr. Nobuhiro Hanada received a research grant from Shiken Corp. This does not alter our adherence to PLOS ONE policies on sharing data and materials. There are no other competing interests to declare. Medoc International Co. Ltd.: http://www.medoc.co.jp/company Shiken Corp.: https://www.shiken-jp.com.
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References M Kebschull (pone.0257247.ref003) 2010; 89
MS Putt (pone.0257247.ref022) 2014; 27
Y Tamaki (pone.0257247.ref023) 2006; 48
J Tang (pone.0257247.ref030) 2000; 275
pone.0257247.ref018
M Orlandi (pone.0257247.ref010) 2014; 236
F Mercanoglu (pone.0257247.ref011) 2004; 75
VY Wahaidi (pone.0257247.ref019) 2011; 38
JR Elter (pone.0257247.ref013) 2006; 151
MS Putt (pone.0257247.ref021) 2013; 24
JA Vita (pone.0257247.ref027) 2002; 106
G Isola (pone.0257247.ref006) 2021; 122
ME Widlansky (pone.0257247.ref007) 2003; 42
JT Kielstein (pone.0257247.ref033) 2004; 109
M Juonala (pone.0257247.ref035) 2007; 116
A Blum (pone.0257247.ref014) 2007; 18
M Czesnikiewicz-Guzik (pone.0257247.ref017) 2019; 40
MAL Saffi (pone.0257247.ref016) 2018; 24
D Ardigo (pone.0257247.ref036) 2007; 37
M Wolgin (pone.0257247.ref028) 2021
RJ MacAllister (pone.0257247.ref031) 1994; 112
AL Moens (pone.0257247.ref026) 2005; 127
PB Lockhart (pone.0257247.ref001) 2012; 125
G Isola (pone.0257247.ref005) 2021
J Najbauer (pone.0257247.ref029) 1993; 268
MS Tonetti (pone.0257247.ref015) 2007; 356
pone.0257247.ref025
I Olsen (pone.0257247.ref002) 2008; 39
MS Putt (pone.0257247.ref020) 2012; 23
V Achan (pone.0257247.ref032) 2003; 23
JN Cohn (pone.0257247.ref008) 2004; 109
Y Inaba (pone.0257247.ref009) 2010; 26
G Isola (pone.0257247.ref004) 2021; 56
G Seinost (pone.0257247.ref012) 2005; 149
D Fliser (pone.0257247.ref034) 2005; 35
L Sibal (pone.0257247.ref024) 2010; 6
References_xml – volume: 48
  start-page: 111
  issue: 3
  year: 2006
  ident: pone.0257247.ref023
  article-title: Study of the clinical usefulness of a dental drug system for selective reduction of mutans streptococci using a case series
  publication-title: J Oral Sci
  doi: 10.2334/josnusd.48.111
  contributor:
    fullname: Y Tamaki
– volume: 109
  start-page: 172
  issue: 2
  year: 2004
  ident: pone.0257247.ref033
  article-title: Cardiovascular effects of systemic NO synthase inhibition with asymmetric dimethylarginine in humans
  publication-title: Circulation
  doi: 10.1161/01.CIR.0000105764.22626.B1
  contributor:
    fullname: JT Kielstein
– volume: 356
  start-page: 911
  issue: 9
  year: 2007
  ident: pone.0257247.ref015
  article-title: Treatment of periodontitis and endothelial function
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa063186
  contributor:
    fullname: MS Tonetti
– volume: 27
  start-page: 273
  issue: 5
  year: 2014
  ident: pone.0257247.ref022
  article-title: A 6-month clinical investigation of custom-made tray application of peroxide gel with or without doxycycline as adjuncts to scaling and root planing for treatment of periodontitis
  publication-title: Am J Dent
  contributor:
    fullname: MS Putt
– volume: 42
  start-page: 1149
  issue: 7
  year: 2003
  ident: pone.0257247.ref007
  article-title: The clinical implications of endothelial dysfunction
  publication-title: J Am Coll Cardiol
  doi: 10.1016/S0735-1097(03)00994-X
  contributor:
    fullname: ME Widlansky
– volume: 268
  start-page: 10501
  issue: 14
  year: 1993
  ident: pone.0257247.ref029
  article-title: Peptides with sequences similar to glycine, arginine-rich motifs in proteins interacting with RNA are efficiently recognized by methyltransferase(s) modifying arginine in numerous proteins
  publication-title: J Biol Chem
  doi: 10.1016/S0021-9258(18)82227-X
  contributor:
    fullname: J Najbauer
– volume: 23
  start-page: 1455
  issue: 8
  year: 2003
  ident: pone.0257247.ref032
  article-title: Asymmetric dimethylarginine causes hypertension and cardiac dysfunction in humans and is actively metabolized by dimethylarginine dimethylaminohydrolase
  publication-title: Arterioscler Thromb Vasc Biol
  doi: 10.1161/01.ATV.0000081742.92006.59
  contributor:
    fullname: V Achan
– volume: 122
  start-page: 104997
  year: 2021
  ident: pone.0257247.ref006
  article-title: Identification of the different salivary Interleukin-6 profiles in patients with periodontitis: a cross-sectional study
  publication-title: Arch Oral Biol
  doi: 10.1016/j.archoralbio.2020.104997
  contributor:
    fullname: G Isola
– volume: 23
  start-page: 48
  issue: 2
  year: 2012
  ident: pone.0257247.ref020
  article-title: Custom-made tray application of peroxide gel as an adjunct to scaling and root planing in the treatment of periodontitis: a randomized, controlled three-month clinical trial
  publication-title: J Clin Dent
  contributor:
    fullname: MS Putt
– volume: 6
  start-page: 82
  issue: 2
  year: 2010
  ident: pone.0257247.ref024
  article-title: The role of asymmetric dimethylarginine (ADMA) in endothelial dysfunction and cardiovascular disease
  publication-title: Curr Cardiol Rev
  doi: 10.2174/157340310791162659
  contributor:
    fullname: L Sibal
– volume: 75
  start-page: 1694
  issue: 12
  year: 2004
  ident: pone.0257247.ref011
  article-title: Endothelial dysfunction in patients with chronic periodontitis and its improvement after initial periodontal therapy
  publication-title: J Periodontol
  doi: 10.1902/jop.2004.75.12.1694
  contributor:
    fullname: F Mercanoglu
– volume: 24
  start-page: 100
  issue: 3
  year: 2013
  ident: pone.0257247.ref021
  article-title: Custom-made tray application of peroxide gel as an adjunct to scaling and root planing in the treatment of periodontitis: results of a randomized controlled trial after six months
  publication-title: J Clin Dent
  contributor:
    fullname: MS Putt
– volume: 236
  start-page: 39
  issue: 1
  year: 2014
  ident: pone.0257247.ref010
  article-title: Association between periodontal disease and its treatment, flow-mediated dilatation and carotid intima-media thickness: a systematic review and meta-analysis
  publication-title: Atherosclerosis
  doi: 10.1016/j.atherosclerosis.2014.06.002
  contributor:
    fullname: M Orlandi
– volume: 151
  start-page: 47
  issue: 1
  year: 2006
  ident: pone.0257247.ref013
  article-title: The effects of periodontal therapy on vascular endothelial function: a pilot trial
  publication-title: Am Heart J
  doi: 10.1016/j.ahj.2005.10.002
  contributor:
    fullname: JR Elter
– volume: 40
  start-page: 3459
  issue: 42
  year: 2019
  ident: pone.0257247.ref017
  article-title: Causal association between periodontitis and hypertension: evidence from Mendelian randomization and a randomized controlled trial of non-surgical periodontal therapy
  publication-title: Eur Heart J
  doi: 10.1093/eurheartj/ehz646
  contributor:
    fullname: M Czesnikiewicz-Guzik
– volume: 116
  start-page: 1367
  issue: 12
  year: 2007
  ident: pone.0257247.ref035
  article-title: Brachial artery flow-mediated dilation and asymmetrical dimethylarginine in the cardiovascular risk in young Finns study
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.107.690016
  contributor:
    fullname: M Juonala
– volume: 125
  start-page: 2520
  issue: 20
  year: 2012
  ident: pone.0257247.ref001
  article-title: Periodontal disease and atherosclerotic vascular disease: does the evidence support an independent association?: a scientific statement from the American Heart Association
  publication-title: Circulation
  doi: 10.1161/CIR.0b013e31825719f3
  contributor:
    fullname: PB Lockhart
– volume: 112
  start-page: 43
  issue: 1
  year: 1994
  ident: pone.0257247.ref031
  article-title: Metabolism of methylarginines by human vasculature; implications for the regulation of nitric oxide synthesis
  publication-title: Br J Pharmacol
  doi: 10.1111/j.1476-5381.1994.tb13026.x
  contributor:
    fullname: RJ MacAllister
– volume: 39
  start-page: 173
  issue: 2
  year: 2008
  ident: pone.0257247.ref002
  article-title: Update on bacteraemia related to dental procedures
  publication-title: Transfus Apher Sci
  doi: 10.1016/j.transci.2008.06.008
  contributor:
    fullname: I Olsen
– volume: 37
  start-page: 263
  issue: 4
  year: 2007
  ident: pone.0257247.ref036
  article-title: ADMA is independently related to flow-mediated vasodilation in subjects at low cardiovascular risk
  publication-title: Eur J Clin Invest
  doi: 10.1111/j.1365-2362.2007.01781.x
  contributor:
    fullname: D Ardigo
– volume: 106
  start-page: 640
  issue: 6
  year: 2002
  ident: pone.0257247.ref027
  article-title: Endothelial function: a barometer for cardiovascular risk?
  publication-title: Circulation
  doi: 10.1161/01.CIR.0000028581.07992.56
  contributor:
    fullname: JA Vita
– volume: 109
  start-page: IV31
  issue: 25 Suppl 1
  year: 2004
  ident: pone.0257247.ref008
  article-title: Surrogate markers for cardiovascular disease: functional markers
  publication-title: Circulation
  contributor:
    fullname: JN Cohn
– volume: 89
  start-page: 879
  issue: 9
  year: 2010
  ident: pone.0257247.ref003
  article-title: “Gum bug, leave my heart alone!”-epidemiologic and mechanistic evidence linking periodontal infections and atherosclerosis
  publication-title: J Dent Res
  doi: 10.1177/0022034510375281
  contributor:
    fullname: M Kebschull
– year: 2021
  ident: pone.0257247.ref028
  article-title: A randomized controlled trial on the plaque-removing efficacy of a low-abrasive air-polishing system to improve oral health care
  publication-title: Quintessence Int
  contributor:
    fullname: M Wolgin
– volume: 38
  start-page: 412
  issue: 5
  year: 2011
  ident: pone.0257247.ref019
  article-title: Endotoxemia and the host systemic response during experimental gingivitis
  publication-title: J Clin Periodontol
  doi: 10.1111/j.1600-051X.2011.01710.x
  contributor:
    fullname: VY Wahaidi
– year: 2021
  ident: pone.0257247.ref005
  article-title: Periodontitis activates the NLRP3 inflammasome in serum and saliva
  publication-title: J Periodontol
  contributor:
    fullname: G Isola
– volume: 18
  start-page: 295
  issue: 4
  year: 2007
  ident: pone.0257247.ref014
  article-title: Periodontal care may improve endothelial function
  publication-title: Eur J Intern Med
  doi: 10.1016/j.ejim.2006.12.003
  contributor:
    fullname: A Blum
– volume: 35
  start-page: 71
  issue: 2
  year: 2005
  ident: pone.0257247.ref034
  article-title: Asymmetric dimethylarginine (ADMA): the silent transition from an ’uraemic toxin’ to a global cardiovascular risk molecule
  publication-title: Eur J Clin Invest
  doi: 10.1111/j.1365-2362.2005.01457.x
  contributor:
    fullname: D Fliser
– volume: 24
  start-page: 1349
  issue: 7
  year: 2018
  ident: pone.0257247.ref016
  article-title: Periodontal therapy and endothelial function in coronary artery disease: a randomized controlled trial
  publication-title: Oral Dis
  doi: 10.1111/odi.12909
  contributor:
    fullname: MAL Saffi
– volume: 127
  start-page: 2254
  issue: 6
  year: 2005
  ident: pone.0257247.ref026
  article-title: Flow-mediated vasodilation: a diagnostic instrument, or an experimental tool?
  publication-title: Chest
  doi: 10.1378/chest.127.6.2254
  contributor:
    fullname: AL Moens
– ident: pone.0257247.ref018
– volume: 26
  start-page: 631
  issue: 6
  year: 2010
  ident: pone.0257247.ref009
  article-title: Prediction of future cardiovascular outcomes by flow-mediated vasodilatation of brachial artery: a meta-analysis
  publication-title: Int J Cardiovasc Imaging
  doi: 10.1007/s10554-010-9616-1
  contributor:
    fullname: Y Inaba
– ident: pone.0257247.ref025
– volume: 275
  start-page: 19866
  issue: 26
  year: 2000
  ident: pone.0257247.ref030
  article-title: Protein-arginine methyltransferase I, the predominant protein-arginine methyltransferase in cells, interacts with and is regulated by interleukin enhancer-binding factor 3
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M000023200
  contributor:
    fullname: J Tang
– volume: 56
  start-page: 597
  issue: 3
  year: 2021
  ident: pone.0257247.ref004
  article-title: Analysis of galectin-3 levels as a source of coronary heart disease risk during periodontitis
  publication-title: J Periodontal Res
  doi: 10.1111/jre.12860
  contributor:
    fullname: G Isola
– volume: 149
  start-page: 1050
  issue: 6
  year: 2005
  ident: pone.0257247.ref012
  article-title: Periodontal treatment improves endothelial dysfunction in patients with severe periodontitis
  publication-title: Am Heart J
  doi: 10.1016/j.ahj.2004.09.059
  contributor:
    fullname: G Seinost
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Snippet Although a significant association between periodontal disease and atherosclerotic cardiovascular disease has been reported, their cause-to-effect relationship...
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SubjectTerms Activities of daily living
Adult
Aged
Anesthesiology
Arginine - analogs & derivatives
Arginine - blood
Arteriosclerosis
Atherosclerosis
Atherosclerosis - complications
Atherosclerosis - prevention & control
Biology and Life Sciences
Biomarkers - blood
Brachial Artery - pathology
Cardiovascular disease
Cardiovascular diseases
Care and treatment
Clinical trials
Confidence intervals
Dental plaque
Dentistry
Dilatation, Pathologic
Disinfectants
Endothelium, Vascular - drug effects
Evaluation
Female
Follow-Up Studies
Gum disease
Health sciences
Hospitals
Humans
Hypotheses
Japan
Male
Mandible - physiology
Maxilla - physiology
Medicine
Medicine and Health Sciences
Middle Aged
Oral hygiene
Oral Hygiene - methods
Patients
People and Places
Periodontal disease
Periodontal diseases
Periodontal Diseases - prevention & control
Periodontal Diseases - therapy
Reduction
Research and Analysis Methods
Self Care
Self-care, Health
Social research
Treatment Outcome
Young Adult
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Title Effect of advanced periodontal self-care in patients with early-stage periodontal diseases on endothelial function: An open-label, randomized controlled trial
URI https://www.ncbi.nlm.nih.gov/pubmed/34555048
https://www.proquest.com/docview/2575815608/abstract/
https://search.proquest.com/docview/2576649149
https://pubmed.ncbi.nlm.nih.gov/PMC8459983
https://doaj.org/article/f1d8fd3cff594ae5902f131937a89bb2
http://dx.doi.org/10.1371/journal.pone.0257247
Volume 16
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