Updating Fearful Memories with Extinction Training during Reconsolidation: A Human Study Using Auditory Aversive Stimuli

• Published in: PloS one Vol. 7; no. 6; p. e38849
• Main Authors: Oyarzún, Javiera P., Lopez-Barroso, Diana, Fuentemilla, Lluís, Cucurell, David, Pedraza, Carmen, Rodriguez-Fornells, Antoni, de Diego-Balaguer, Ruth
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 29.06.2012; Public Library of Science (PLoS)
• Subjects: Acoustic Stimulation; Acoustics; Anxiety; Auditory discrimination learning; Biology; Biomedical research; Brain research; Cognition & reasoning; Conditioned stimulus; Conditioning; Conductance; Disorders; Drugs; Environmental audits; Extinction, Psychological - physiology; Fear; Fear & phobias; Fear - physiology; Fear conditioning; Female; Galvanic Skin Response; Hazards; Humans; Male; Medical research; Medicine; Memory; Memory - physiology; Neurobiology; Neurosciences; Photic Stimulation; Post traumatic stress disorder; Protein synthesis; Proteins; Psychopharmacology; Reminder; Reminder effects; Resistance; Rodents; Skin conductance response; Social and Behavioral Sciences; Stimuli; Studies; Training; Young Adult; Spain

Learning to fear danger in the environment is essential to survival, but dysregulation of the fear system is at the core of many anxiety disorders. As a consequence, a great interest has emerged in developing strategies for suppressing fear memories in maladaptive cases. Recent research has focused...