Mitochondrial Transcription Factor A (TFAM) Binds to RNA Containing 4-Way Junctions and Mitochondrial tRNA

• Published in: PloS one Vol. 10; no. 11; p. e0142436
• Main Authors: Brown, Timothy A, Tkachuk, Ariana N, Clayton, David A
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 06.11.2015; Public Library of Science (PLoS)
• Subjects: Animals; Binding; Biosynthesis; Cloning; Deoxyribonucleic acid; DNA; DNA-Binding Proteins - metabolism; E coli; Experiments; Gene expression; High Mobility Group Proteins - metabolism; Hybrids; Kinetics; Localization; Mice; Mitochondria; Mitochondrial DNA; Mutation; Nucleic Acid Conformation; Nucleoids; Packaging; Protein Binding; Proteins; Ribonuclease; Ribonucleic acid; RNA; RNA - chemistry; RNA - metabolism; RNA processing; RNA, Mitochondrial; RNA, Transfer - chemistry; RNA, Transfer - metabolism; Substrates; Surface Plasmon Resonance; Swiss 3T3 Cells; Transcription factors; Transfer RNA; tRNA; United States; United States > US; Virginia

Mitochondrial DNA (mtDNA) is maintained within nucleoprotein complexes known as nucleoids. These structures are highly condensed by the DNA packaging protein, mitochondrial Transcription Factor A (TFAM). Nucleoids also include RNA, RNA:DNA hybrids, and are associated with proteins involved with RNA...