Hypomethylation mediates genetic association with the major histocompatibility complex genes in Sjögren’s syndrome

• Published in: PloS one Vol. 16; no. 4; p. e0248429
• Main Authors: Chi, Calvin, Taylor, Kimberly E., Quach, Hong, Quach, Diana, Criswell, Lindsey A., Barcellos, Lisa F.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 22.04.2021; Public Library of Science (PLoS)
• Subjects: Adult; Biology and life sciences; Care and treatment; Computer applications; CpG islands; Data processing; Development and progression; Disease; DNA Methylation; DNA probes; Engineering schools; Epidemiology; Epigenesis, Genetic; Epigenetics; Female; Gene expression; Gene loci; Genetic aspects; Genomes; Genomics; Health aspects; Health risk assessment; Health risks; Humans; Laboratories; Major Histocompatibility Complex; Medicine and Health Sciences; Methylation; Middle Aged; Morbidity; Outdoor air quality; Principal components analysis; Probes; Public health; Quality control; Quantitative Trait Loci; Questioning; Research facilities; Rheumatology; Sjogren's syndrome; Sjogren's Syndrome - genetics; United States; United States > US; San Francisco California; California

Differential methylation of immune genes has been a consistent theme observed in Sjögren’s syndrome (SS) in CD4+ T cells, CD19+ B cells, whole blood, and labial salivary glands (LSGs). Multiple studies have found associations supporting genetic control of DNA methylation in SS, which in the absence...