Critical reappraisal of neoadjuvant concurrent chemoradiotherapy for treatment of locally advanced colon cancer

• Published in: PloS one Vol. 16; no. 11; p. e0259460
• Main Authors: Chen, Yen-Cheng, Tsai, Hsiang-Lin, Li, Ching-Chun, Huang, Ching-Wen, Chang, Tsung-Kun, Su, Wei-Chih, Chen, Po-Jung, Yin, Tzu-Chieh, Huang, Chun-Ming, Wang, Jaw-Yuan
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 02.11.2021; Public Library of Science (PLoS)
• Subjects: 5-Fluorouracil; Adjuvant treatment; Adult; Aged; Anemia; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Biopsy; Cancer; Cancer therapies; Care and treatment; Chemoradiotherapy; Chemoradiotherapy - methods; Chemotherapy; Clinical medicine; Colon; Colon cancer; Colonic Neoplasms - drug therapy; Colonic Neoplasms - mortality; Colonic Neoplasms - pathology; Colonic Neoplasms - therapy; Colorectal cancer; Colorectal surgery; Combined modality therapy; Complications; Decision making; Disease-Free Survival; Female; Fluorouracil - administration & dosage; Fluorouracil - therapeutic use; Folinic acid; Health services; Hospitals; Humans; Leucovorin - administration & dosage; Leucovorin - therapeutic use; Leukopenia; Lymphatic system; Male; Medical imaging; Medical records; Medical research; Medical schools; Medicine; Medicine and Health Sciences; Metastases; Metastasis; Middle Aged; Multivariate analysis; Neoadjuvant Therapy - methods; Neoplasm Staging; Oncology; Organoplatinum Compounds - administration & dosage; Organoplatinum Compounds - therapeutic use; Oxaliplatin; Patient outcomes; Patients; Postoperative; Prognosis; Radiation therapy; Radiotherapy; Retrospective Studies; Side effects; Skin cancer; Survival; Survival Rate; Toxicity; Treatment Outcome; Taiwan

Locally advanced colon cancer (LACC) is associated with surgical challenges during R0 resection, increased postoperative complications, and unfavorable treatment outcomes. Neoadjuvant concurrent chemoradiotherapy followed by surgical resection is an effective treatment strategy that can increase the...