Retinal neurodegeneration in Wilson's disease revealed by spectral domain optical coherence tomography

• Published in: PloS one Vol. 7; no. 11; p. e49825
• Main Authors: Albrecht, Philipp, Müller, Ann-Kristin, Ringelstein, Marius, Finis, David, Geerling, Gerd, Cohn, Eva, Aktas, Orhan, Hartung, Hans-Peter, Hefter, Harald, Methner, Axel
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 16.11.2012; Public Library of Science (PLoS)
• Subjects: Adult; Automation; Biology; Case-Control Studies; Cirrhosis; Coherence; Copper; Degeneration; Disease control; Evoked Potentials, Visual; Female; Hepatolenticular Degeneration - complications; Humans; Latency; Liver; Liver cirrhosis; Liver diseases; Macula Lutea - pathology; Male; Medical imaging; Medical research; Medicine; Metabolism; Middle Aged; Multiple sclerosis; Nervous system; Neurodegeneration; Neurology; NMR; Nuclear magnetic resonance; Optical Coherence Tomography; Optics; Patients; Retina; Retina - pathology; Retinal Degeneration - diagnosis; Retinal Degeneration - etiology; Sex; Thickness; Tomography; Tomography, Optical Coherence; Visual evoked potentials; Visual system; Germany

In addition to cirrhosis of the liver, Wilson's disease leads to copper accumulation and widespread degeneration of the nervous system. Delayed visual evoked potentials (VEPs) suggest changes to the visual system and potential structural changes of the retina. We used the latest generation of s...