Characterization of a proteomic profile associated with organ dysfunction and mortality of sepsis and septic shock

• Published in: PloS one Vol. 17; no. 12; p. e0278708
• Main Authors: Ruiz-Sanmartín, Adolfo, Ribas, Vicent, Suñol, David, Chiscano-Camón, Luis, Palmada, Clara, Bajaña, Iván, Larrosa, Nieves, González, Juan José, Canela, Núria, Ferrer, Ricard, Ruiz-Rodríguez, Juan Carlos
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 02.12.2022; Public Library of Science (PLoS)
• Subjects: Adult; Apolipoprotein E; Apolipoprotein L1; Biology and Life Sciences; Biomarkers; Blood pressure; CD14 antigen; Complications and side effects; Development and progression; Evolution; Health aspects; Hospitals; Humans; Hypotension; Infections; Laboratories; Mass spectrometry; Mass spectroscopy; Medicine and Health Sciences; Mortality; Multiple Organ Failure; Patient outcomes; Patients; Peptides; Plasma proteins; Prognosis; Prospective Studies; Protein interaction; Proteins; Proteomics; Risk factors; Sensitivity; Sepsis; Septic shock; Shock, Septic; Spectroscopy; Tertiary; Spain

The search for new biomarkers that allow an early diagnosis in sepsis and predict its evolution has become a necessity in medicine. The objective of this study is to identify, through omics techniques, potential protein biomarkers that are expressed in patients with sepsis and their relationship wit...