TLR-9 contributes to the antiviral innate immune sensing of rodent parvoviruses MVMp and H-1PV by normal human immune cells

• Published in: PloS one Vol. 8; no. 1; p. e55086
• Main Authors: Raykov, Zahari, Grekova, Svitlana P, Hörlein, Rita, Leuchs, Barbara, Giese, Thomas, Giese, Nathalia A, Rommelaere, Jean, Zawatzky, Rainer, Daeffler, Laurent
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 29.01.2013; Public Library of Science (PLoS)
• Subjects: Analysis; Animal models; Animals; Biology; Cancer; Cell culture; Cell cycle; Cell Line, Tumor; Cell proliferation; Cell Transformation, Viral - immunology; Cells (Biology); Cytokines; Defects; Dendritic cells; Deoxyribonucleic acid; Diabetes; DNA; Gene expression; Gene therapy; Genome, Viral - genetics; Genomes; Genomics; Health aspects; HEK293 Cells; Herpes viruses; Homology; Humans; Immune system; Immunity, Innate; Infections; Interferon; Interferon Type I - metabolism; Leukocytes (mononuclear); Leukocytes, Mononuclear - immunology; Leukocytes, Mononuclear - metabolism; Leukocytes, Mononuclear - virology; Medical research; Mice; Minute Virus of Mice - genetics; Minute Virus of Mice - physiology; Multiplication; Neutralization; Parvoviruses; Pattern recognition; Pattern recognition receptors; Peripheral blood mononuclear cells; Polypeptides; Rats; Rodents; Signal Transduction - immunology; TLR9 protein; Toll-Like Receptor 9 - metabolism; Toll-like receptors; Transcription factors; Transformed cells; Tumor cells; Viral infections; Viruses; Germany

The oncotropism of Minute Virus of Mice (MVMp) is partially related to the stimulation of an antiviral response mediated by type-I interferons (IFNs) in normal but not in transformed mouse cells. The present work was undertaken to assess whether the oncotropism displayed against human cells by MVMp...