Sodium Salicylate Reduced Insulin Resistance in the Retina of a Type 2 Diabetic Rat Model

• Published in: PloS one Vol. 10; no. 4; p. e0125505
• Main Authors: Jiang, Youde, Thakran, Shalini, Bheemreddy, Rajini, Coppess, William, Walker, Robert J., Steinle, Jena J.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 14.04.2015; Public Library of Science (PLoS)
• Subjects: Animal models; Animals; Apoptosis; Caspase; Caspase 3 - analysis; Caspase-3; Cells, Cultured; Diabetes; Diabetes mellitus; Diabetes Mellitus, Type 2 - metabolism; Diabetes Mellitus, Type 2 - pathology; Diabetic retinopathy; Disease Models, Animal; Electroretinography; Endothelial cells; Endothelial Cells - cytology; Endothelial Cells - drug effects; Endothelial Cells - metabolism; Enzyme-Linked Immunosorbent Assay; Ependymoglial Cells - cytology; Ependymoglial Cells - drug effects; Ependymoglial Cells - metabolism; Glucose - pharmacology; Humans; I-kappa B Proteins - metabolism; Insulin; Insulin - metabolism; Insulin receptor substrate 1; Insulin Receptor Substrate Proteins - metabolism; Insulin Resistance; Intraocular Pressure - physiology; Lysates; Male; Markers; NF-KappaB Inhibitor alpha; Nonsteroidal anti-inflammatory agents; Obesity; Phosphorylation - drug effects; Rats; Rats, Inbred BB; Receptor, Insulin - metabolism; Retina; Retina - drug effects; Retina - metabolism; Retinopathy; Salicylic acid; Signal Transduction - drug effects; Signaling; Sodium; Sodium salicylate; Sodium Salicylate - pharmacology; Substrates; Suppressor of Cytokine Signaling 3 Protein; Suppressor of Cytokine Signaling Proteins - metabolism; Tumor Necrosis Factor-alpha - analysis; Tumor necrosis factor-α; Type 2 diabetes; Western blotting

Sodium salicylate has been reported to reduce markers of diabetic retinopathy in a type 1 rat model. Because rates of type 2 diabetes are on the rise, we wanted to determine whether salicylate could improve insulin resistance in a type 2 rat model, as well as improve retinal function. We treated lea...